Immunogen

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Synopsis: Pharma: Drugs: Immunogen:


timesofindia.indiatimes.com_home_science 2015 00571.txt.txt

but slightly different proteins (immunogens) to train the body to produce broadly neutralizing antibodies against HIV-a twist on the traditional"booster shot,

where a person is exposed to the same immunogen multiple times. The scientists tested one of these potential proteins,

an immunogen called eod-GT8 60mer, using a technique called B cell sorting. The researchers showed that immunisation with eod-GT8 60mer produced antibody"precursors"with some of the traits necessary to recognize


www.technology.org 2015 09580.txt.txt

#Scientists successfully test immunogen a component for potential HIV vaccine Team of researchers from The Scripps Research Institute, INTERNATIONAL AIDS Vaccine Initiative and The Rockefeller University have shown successfully that an experimental vaccine candidate

but slightly different proteins, called immunogens, to train the body to produce broadly neutralizing antibodies against HIV.

so called oostershot, where a person is exposed to the same immunogen multiple times, until develops imunity to a certain disease.

This protein is called an immunogen eod-GT8 60mer. This compound had to be tested, so another lab using genetic engineering created a mouse model to produce antibodies that resemble human antibodies.

This suggests that eod-GT8 60mer immunogen could be a good candidate to serve as the first in a series of immunizations against HIV.

Professor David Nemazee evaluated results like that he vaccine appears to work well in our mouse model to rimethe antibody response In another research scientists used the same immunogen in a slightly different mouse model,

which showed promising results As well as scientists have taken approach to collect a variety of different immunogens to develop a united HIV vaccine,

now they have to find other needed immunogens. For further testing mouse models will have to be developed,


www.technology.org 2015 10206.txt.txt

or treatments for each of the different viruses in this family necessitates intelligent design of immunogens (antibody-inducing molecules).


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