and psychiatric problems and mutations in euchromatic histone methyltransferase 1 (EHMT1) cause similar symptoms in a disease known as 9q34 deletion syndrome.
the Clyde and Helen Wu Professor of Chemical Biology (in Biomedical Informatics and the Institute for Cancer Genetics), chair of the Department of Systems Biology,
and director of the JP Sulzberger Columbia Genome Center, at Columbia's College of Physicians and Surgeons.
C/EBPD, had already been identified by the labs of Dr. Califano and of Antonio Iavarone, MD, professor of neurology and of pathology & cell biology (in the Institute for Cancer Genetics),
The above story is provided based on materials by Whitehead Institute for Biomedical Research. The original article was written by Nicole Giese Rura.
Andersen notes that several medicines already exist that could block autophagy and make chemotherapy more effective.
#Minimally invasive surgery with hydraulic assistance Endoscopic surgery requires great manual dexterity on the part of the operating surgeon.
Minimally invasive techniques, also known as"keyhole surgery,"enable surgeons to operate on patients without requiring major incisions.
allowing the internal organs to be visualized for surgery. Surgical techniques have advanced by leaps and bounds in recent years.
The same cannot be said for surgical instruments. In certain types of endoscope, the tip can be oriented at different angles."
and even physical strength on the part of the surgeon, has changed barely since the earliest days of endoscopy,"says Timo Cuntz, a member of the Project Group for Automation in Medicine and Biotechnology PAMB in Mannheim, a part of the Fraunhofer Institute for Manufacturing Engineering and Automation IPA.
The force required to deflect the tip is transmitted by a wire mechanism known as a Bowden cable (similar to a bicycle brake cable.
The cable mechanism transmits the surgeon's hand movements at one end to the tiny instruments at the other extremity of the endoscope.
making it difficult for the surgeon to manipulate the tissue precisely.""The surgeon's work would be made much easier
if it were possible to reduce the friction and increase the power density. Hydraulic instruments are one of the alternatives being considered as a substitute for mechanical transmission based on Bowden cable."
They allow the surgeon to carry out much finer movements, "says the engineer. A plastic tube filled with a sterile,
biocompatible fluid based on medicinal white oil is used in place of the wire cable. To control the attached instruments and orient the tip of the endoscope,
the surgeon manipulates a hydraulic cylinder or robotic muscle that exerts the required pressure to compress the fluid and push it through the hydraulic tube onto a second, spring-mounted cylinder.
Such hydraulically actuated instruments are suited ideally for use in connection with a technique known as natural orifice transluminal endoscopic surgery (NOTES),
in which the surgeon operates through natural body orifices in order to access internal organs; going through the stomach, for instance,
#Mining big data yields Alzheimers discovery Scientists at The University of Manchester have used a new way of working to identify a new gene linked to neurodegenerative diseases such as Alzheimer's.
which is linked to a group of neurodegenerative diseases. The study has just been published in the journal BMC Genomics.
but also how to distinguish those who would benefit from surgical or other aggressive treatment from those who would not.
Vipul Patel, M d.,medical director of the Global Robotics Institute at Florida Hospital in Orlando."
"said Subinoy Das, MD, an adjunct professor of otolaryngology at Ohio State's College of Medicine,
who is also a professor of Pediatrics and Otolaryngology at Ohio State's College of Medicine."
so that patients can get the best medicine for the specific type of infection that they have.""Das says the research also helps explain why viral infections appear to promote bacterial infections--a primary reason physicians will often"preemptively"prescribe antibiotics."
An accomplished sinus surgeon, Das is working with his nurses and staff to engineer and test hundreds of nasal swab collection devices to make sure that they are simple
or dangerous by the immune system of the skin said Cecilia Berin Phd Associate professor of Pediatrics at the Icahn School of medicine at Mount sinai.
However, there are few prospective epidemiological studies examining the association of fried food consumption with other health outcomes,
Igor Spetic had family open his medicine bottles. Cotton balls give him goose bumps. Now, blindfolded during an experiment,
"How the system works and the results will be published online in the journal Science Translational Medicine Oct 8."
Surgeons Michael W Keith, MD and J. Robert Anderson, MD, from Case Western Reserve School of medicine and Cleveland VA, implanted three electrode cuffs in Spetic
An article about this achievement and its long-term stability will now be published in the Science Translational Medicine journal."
Rickard Brånemark led the surgical implantation and collaborated closely with Max Ortiz Catalan and Professor Bo Håkansson at Chalmers University of Technology on this project.
Before the surgery, his prosthesis was controlled via electrodes placed over the skin. Robotic prostheses can be advanced very,
and since the surgery he has experienced that he can cope with all the situations he faces; everything from clamping his trailer load and operating machinery,
"said Dr. Steven Marso, Medical Director of Interventional Cardiology and Professor of Internal medicine.""People who wouldn't have had an option for treatment now have an option for treatment,
The research team included several Luxembourg biomedical research institutions: The National Health Laboratory the Santé Public Research Centre and the Integrated Biobank of Luxembourg.
Department of Reproductive Medicine at KKH, said, "This important discovery will allow us to identify
#Smallest world record has ndless possibilitiesfor bionanotechnology Scientists from the University of Leeds have taken a crucial step forward in bionanotechnology a field that uses biology to develop new tools for science technology and medicine.
The Utah group has developed previously highly potent and broadly acting D-peptide inhibitors of HIV entry, currently in preclinical studies,
Now Zeng and colleagues from the University of Kansas Medical center and KU Cancer Center have published just a breakthrough paper in the Royal Society of Chemistry journal describing their invention of a miniaturized biomedical testing device for exosomes.
Specifically principal investigator Albert R. La Spada MD Phd professor of cellular and molecular medicine chief of the Division of Genetics in the Department of Pediatrics and associate director of the Institute for Genomic
Medicine at UC San diego and colleagues found that a microrna known as let-7 controls autophagy through the amino acid sensing pathway which has emerged as the most potent activator of mtorc1 complex activity.
and colleagues have shown that a lentivirus encoding let-7 injected into mouse neurons promotes the autophagic turnover of toxic misfolded proteins associated with neurodegenerative disease. e also demonstrate that treatment with anti-let-7 can block autophagy
These results are published in the journal Translational Psychiatry in the online issue of 7 october 2014.
Despite various psychiatric genetic and neurobiological studies the molecular mechanism responsible for these disorders remains mysterious.
and restore tissue integrity by activating stem cells said Abdallah Elkhal Phd BWH Division of Transplant Surgery and Transplantation Surgery Research Laboratory senior study author.
The scientists performed preclinical trials using experimental autoimmune encephalomyelitis a preclinical model for human multiple sclerosis.
not only autoimmune diseases but other acute or chronic conditions such as allergy chronic obstructive pulmonary disease sepsis and immunodeficiency said Stefan G. Tullius MD Phd BWH Chief of Transplant Surgery
and Director of Transplantation Surgery Research lead study author. Moreover the researchers demonstrated that NAD+can restore tissue integrity
and as a whole--would be packed with complex genes with the potential to answer some of the most pressing questions in medical biology.
Results of the study are published in the Journal of American College of Cardiology Heart failure. Heart failure is one of the fastest growing forms of heart disease
and it's one of the most common reasons people are hospitalized said Abraham director of the Division of Cardiovascular Medicine at Ohio State's Wexner Medical center.
and when disrupted it can lead to neurodegenerative diseases, "said Dr. Perlson.""Understanding how an organism such as rabies manipulates this machinery may help us in the future to either restore the process
the researchers hope their findings will allow scientists to control the neuronal transport machinery to treat rabies and other neurodegenerative diseases.
Disruptions of the neuron train system also contribute to neurodegenerative diseases, like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS.
Evilevitch hopes that the research findings will lead to a new type of medicine that targets the phase transition for virus DNA
#Advantages, potential of computer-guided spinal surgery In a series of research studies Cedars-Sinai spinal surgeons show that a new method of computer-guided spine surgery is beneficial for spinal reconstruction
The Cedars-Sinai surgeons highlight the advantages of a spinal navigation technique that uses high-speed computerized tomography (CT) imaging to navigate in and around the spinal column from different angles.
They present their findings in six articles published in the current issue of Neurosurgical Focus an online peer-reviewed journal published by the American Association of Neurological Surgeons.
It allows surgeons to more precisely and accurately place reconstruction screws in the narrow bony corridors of the spine avoiding nerves blood vessels and other critical structures.
and the need for follow-up surgeries they write. Computer-guided surgical navigation technology delivers on quality
and safety said J. Patrick Johnson MD a neurosurgery spine specialist and director of Spine Education and the Neurosurgery Spine Fellowship program in the Department of Neurosurgery.
It clearly improves outcomes in spine care. The computerized navigation system uses a mobile CT SCANNER to take cross-sectional images of the spine
while a patient is in surgery. The images are transferred to a computer which displays them on overhead monitors that allow precise tracking of surgical instruments as surgeons insert screws for reconstruction
and perform other complex procedures on the spine. Surgeons said the technique is superior to existing methods because of its precision and speed.
They point out that even small miscalculations with two-dimensional technology can cause problems that require follow-up operations
The Cedars-Sinai surgeons say they have cut these to nearly zero by using computer-guided methods.
The surgeons said the technology has others applications for treating spinal disorders serving as a tool to remove tumors decompress the spinal column
and perform minimally-invasive surgery. This approach represents a major leap forward for instrumented spine surgery said Terrence T. Kim MD an orthopedic spine surgeon in the Cedars-Sinai Spine Center and expert in the computer-guided navigation field.
We're looking at the future. Joining Drs. Johnson and Kim as study co-authors are Doniel Drazin MD a senior resident in the Department of Neurosurgery and Robert S. Pashman MD a clinical associate professor and orthopedic spine surgeon at the Cedars
-Sinai Spine Center. The group's studies accounted for six of 10 articles in the March issue of Neurological Focus.
A spokeswoman at the online journal said it is highly unusual for a single institution to publish a majority of articles in a single journal issue.
and computer-aided system used during minimally invasive surgery increased the accuracy of screw placement into vertebral pedicle bones.
and the mobile CT SCANNER allowed for more accurate surgical placement even within the narrowest parts of the thoracic spine particularly challenging regions in women
A third study determined that the image-guided technique can be useful for other minimally invasive procedures including thoracic endoscopic spine surgery to remove tumors infections
The final two articles offer an overview of computer-guided surgery of the spine including its use in revision
or redo spine surgeries that are often the most complex; and the potential future use of robotic spine surgery with computer navigation.
The special issue of the journal can be accessed at: http://thejns. org/toc/foc/36/3story Source:
#Painting robot lends surgeons a hand in the operating room Would you let an artist perform lifesaving surgery on you?
and shapes a surgeon makes with a scalpel using a paintbrush and canvas. His invention a creative blend of art and science could one day lend doctors a hand in practicing complex robot-assisted surgeries without having to step foot in an operating room.
Rethinking roboticslee a sophomore who plans to major in chemistry spent his high school years building everything from a robot that can balance on a beam to a robotic arm that can throw a ball.
and that prompted the idea of robotic surgery. Lee said painting and surgery have more in common than initially meets the eye.
A painter has to be nimble and precise with his brushstrokes much like a surgeon must be nimble and precise with a scalpel.
When you are dissecting a part of the human body you have to be one hundred percent perfect he said.
and shapes a surgeon makes with a scalpel all on its own he said. You can think of a painting canvas as a body and the brush as a surgeon's knife.
Practicing in a surgeon's studiocurrently surgical robots are controlled by a human operator and do not perform procedures autonomously.
While Lee's robot may never be put to work in an operating room it and other robots like it could one day help researchers to design fully autonomous robotic surgeons.
In addition to teaching the robot to paint autonomously Lee also explored the idea of using his robot as a training tool for surgeons who need practice operating a Da vinci surgical arm.
At the Wake Forest Medical center doctors use replica bodies to help train surgeons to use the Da vinci system Lee said.
These replicas are compared pretty expensive to my robotic arm which cost around $1500. This April Lee will represent Wake Forest at the ACC Meeting of the Minds an event where outstanding undergraduate researchers from each ACC university gather at one member university to present their research either verbally or as a poster.
This research was funded by the Kathy and Curt Marble Cancer Research Fund through the Koch Institute Frontier Research Program, the National Cancer Institute, the National Institute of General medicine Sciences
and the Howard Hughes Medical Institute. Publication: Armon Sharei, et al. x Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells, PLOS One, 2015;
The research was published online today in the journal Nature Medicine. Tseng collaborated with HSCI Lee Rubin and researchers at the National institutes of health, the Joslin, Boston University, Beth Israel Deaconess Hospital,
Tseng hopes this technique could eventually replace invasive procedures such as liposuction and gastric bypass surgery.
lonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes, Nature Medicine, 2015;
or analyzing tissue samples for biomedical research and diagnostics. Replacing that bulky optical equipment with quantum dots allowed the MIT team to shrink spectrometers to about the size of a U s. quarter,
and an associate professor of medicine in the division of hematology and oncology at the David Geffen School of medicine at UCLA. Kitchen and his colleagues were the first to report the use of an engineered molecule called a chimeric antigen receptor,
said Jerome Zack, professor of medicine and of microbiology, immunology and molecular genetics in the UCLA David Geffen School of medicine and a co-author of the study. ith the CAR approach,
The study first author was Anjie Zhen, a postdoctoral fellow at UCLA in the Division of Hematology/Oncology, the UCLA AIDS Institute and the Broad Stem Cell Research center.
Bobak Mosadegh of Weill Cornell Medical College; and, as noted, Whitesides of Harvard and the Wyss Institute.
The research findings are published early online in the Journal of the American Academy of Dermatology.
such as steroid creams and oral medicines, commonly fail to relieve symptoms in patients with moderate to severe eczema.
Based on current scientific models of eczema biology, assistant professor of dermatology Dr. Brett King. hypothesized that a drug approved for rheumatoid arthritis,
King and fellow Yale dermatologist Dr. Brittany Craiglow had shown previously that tofacitinib citrate regrows hair in patients with an autoimmune-related form of hair loss called alopecia areata.
from environmental remediation to medical analysis. The polymers are synthesized at room temperature, and don need to be prepared specially to target specific compounds;
offering the example of a cheap testing kit for urine analysis of medical patients. The study also suggests the broader potential for adapting nanoscale drug-delivery techniques developed for use in environmental remediation. hat we can apply some of the highly sophisticated,
and an expert in nanoengineering for health care and medical applications. hen you think about field deployment,
said Ruth Halaban, senior research scientist in dermatology, a member of Yale Cancer Center, and lead author of the study. oss of NF1 requires more accompanying changes to make a tumor,
This panel of genes can now be used in precision medicine to diagnose malignant lesions and can be applied to personalized cancer treatment.
the Howard Hughes Medical Institute; the Department of Dermatology; and the Yale Comprehensive Cancer Center.
Publication: Michael Krauthammer, et al, xome sequencing identifies recurrent mutations in NF1 and RASOPATHY genes in sun-exposed melanomas, Nature Genetics, 2015;
A connection that saves lives Qualcomm is changing that by providing something that you won find in a typical medical bag:
or used in medical treatments. Other cities using the system benefit from New york work and they can provide their own suggestions.
and could be on the cusp of market approval, Nature Medicine reports. Nearly a quarter-million KI doses (pictured) have been amassed by evacuation centers near the site.
and the Pandemic and All-Hazard Preparedness Act (signed into law 2 years later) allotted billions of dollars in funding for research into medical countermeasures to be used in the case of nuclear, chemical,
We can create personalized medical information. Anywhere there is data and there is interest. Our hope is to be able to do something for the 2010 census
says Francine R. Kaufmann, the company chief medical officer and a practicing endocrinologist. Why the long delay between the proof of concept and routine use?
so the insulin can get to the liver more quickly. ut youe talking about surgery, Haidar says. f you have a 2-year-old daughter,
a medical geneticist who heads artificial-pancreas research for the JDRF. A third kind of algorithm tries to model human physiology, for instance by considering how quickly food passes through your system
Erik had no qualms about signing up for brain surgery, but his mother wasn happy about it. he was just being a mom,
the surgery gave Sorto superhuman abilities. In the experiments, Sorto simply imagines reaching out to grab an object
To prepare for Sorto surgery in April 2013 the researchers first used functional magnetic resonance imaging to identify two precise regions of his parietal cortex that activated when he imagined reaching and grasping motions.
The surgeons implanted two tiny microelectrode arrays, each with 96 electrodes that could record the electrical activity of single neurons.
Within one month of surgery, Sorto was ready to get to work. The researchers connected cables to the pedestals, bringing the neural signals to a computer that analyzed them and sent commands to the robot arm.
More than two years after his surgery, his electrodes are still functioning and his enthusiasm is undimmed.
there little that orthopedists can do to regenerate a torn knee meniscus, said study leader Jeremy Mao in a release. ome small tears can be sewn back in place,
But more importantly, employees dealing with sensitive information seem not to understand that email is not a place where an HR employee needs to be detailing a child medical treatment,
or which child medical claims were being denied. The media has reported, however, that is the kind of information these documents contain.
and thermometer are the two most important tools we have in medicine for diagnosing common conditions,
Like Scanadu devices, the Clinicloud medical kit hooks information from the app up with remote physicians.
You can even share your toothbrushing data with your dentist or hygienist and an Oral B spokesperson told me me at an event at Mobile World Congress last week,
Turning iphones Into Medical Diagnostic Devices Medical research is plagued by small sample sizes and inconsistent data collection.
a new ios software framework that lets people volunteer to join medical research studies. Researchkit lets people take tests like saying hhhto detect vocal variations, walking in a line,
Apple learned about some of the biggest obstacles to scientific research in medicine. Finding and recruiting subjects can be tough.
With Researchkit, researchers can build out a medical testing app for ios that accessible to people far from their physical lab. Users can signup with a digital signature,
Since medical data is obviously sensitive, Apple won see anything you put into Researchkit apps and you can give permissions for how data is used by researchers.
it could make mass medical research easier than ever r
#Purelifi Raises £1. 5m For Tech That Uses Pulsating LED Light To Create Wifi Alternative Purelifi,
companies like Matternet are creating drones that will deliver medicine. Then there are drones that will deliver life vests to drowning victims,
It uses a 3d-printed add-on that can allow ophthalmologists to give detailed and complete eye exams in the field using an app and a small camera overlay.
Created by British ophthalmologists, the system recently hit £130, 475 on Indiegogo and is now up for pre-order by doctors.
Medical images taken by Peek can be sent to doctors remotely to diagnose and suggest treatments for patients.
ophthalmologists are able to address eye care problems anywhere in the world. Interestingly, the system also allows you to give eye tests by showing increasingly smaller letters and figures on the screen.
By bringing the tools of an ophthalmology office into your pocket and offering a very simple and inexpensive way to take great pictures inside the eye doctors can visit locations in need
but also includes data on medical conditions that a user can pre-populate into the app.
Thus, if you have a medical emergency and press the button, it will automatically send potential allergies
however, with a health-focused wristband that provides constant patient information for participants in medical studies and clinical field trials.
and the dedicated medical wearable unveiled today also monitors and reports information continuously, for better delivery of real-time actionable info to researchers and medical professionals.
Testing for the medical band begins this summer, according to Google, and it going to pursue regulatory approval for its use in medical contexts in partnership with academic institutions and drug companies, per Bloomberg.
This isn Google first move in building medical hardware; Google X is also creating contact lenses that can monitor blood glucose level to help in managing conditions like diabetes.
The competition is also eager to contribute to the medical research community pple has introduced Researchkit,
which allows studies to use iphones and ipads to gather participant data from a wider potential user pool, for instance o
it could earn a fortune undercutting standard $50 to $100 ophthalmologist visits and making the world see clearer.
However, Opternative can detect eye-based medical conditions, so youl still need to visit a doctor every few years to check for those.
Google researchers created the software through a kind of digital brain surgery, plugging together two neural networks developed separately for different tasks.
The world wants mobile medical apps (MMAS) ##and demand won t slow down any time soon. The demand for remote patient monitoring is growing dramatically says Jeannette Tighe from the Healthtech Advisory practice at Sagentia a global technology advisory
and released draft guidance proposing deregulation of medical data aggregation systems. This clarification she says significantly reduces the risks of these opportunities for medical technology companies.
Currently most FDA-regulated apps are either stand-alone or act as accessories to existing medical devices and allow the smartphone to act as a##dumb-user interface
The world wants mobile medical apps (MMAS) ##and demand won t slow down any time soon. The demand for remote patient monitoring is growing dramatically says Jeannette Tighe from the Healthtech Advisory practice at Sagentia a global technology advisory
and released draft guidance proposing deregulation of medical data aggregation systems. This clarification she says significantly reduces the risks of these opportunities for medical technology companies.
Currently most FDA-regulated apps are either stand-alone or act as accessories to existing medical devices and allow the smartphone to act as a##dumb-user interface
Now he is going a step further collaborating with surgeons and other researchers on ways to allow bionic limbs to be controlled directly by the nervous system
Whereas brain-machine interfaces would require invasive surgery for brain implants he wants to connect electronic devices to the peripheral nerves at the site of the injury allowing people to control bionic limbs with their existing nerves
Amputation which is currently a fairly crude surgery might become a sophisticated procedure of setting up the body to interface with a bionic limb.
a way to get xhaustive medical infoin reports that are imilar, but not as pretty.
its medical meaning is less certain. Consumer DNA tests determine which common versions of the 23,000 human genes make up your individual genotype.
In barring 23andme health reports, the FDA also cited the danger that erroneous interpretations of gene data could lead someone to seek out unnecessary surgery
whether consumers should have the right to get genetic facts without going through a doctor. t an almost philosophical issue about how medicine is going to be delivered,
a professor at Stanford university who helped developed a DNA interpretation site called Interpretome as part of a class he teaches on genetics. s it going to be concentrated by medical associations,
Two of the sites appeared designed to steer users toward alternative medicine. Genetic Genie, a free service that carries ads for vitamins,
At least that the current view of the FDA and medical societies. But Deboe did take the report to her doctor.
and avoid drugs like Novocain. think that how people should be using thiss a conversation-starter with medical professionals,
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