#Wall street journal Highlights Promising Gene therapy Advances Yesterday, bluebird bio reported some very uplifting news at the annual meeting of the American Society of Hematology.
Alexis A. Thompson, head of hematology at Northwestern University Feinberg School of medicine in Chicago, and lead investigator of the study. n a relatively short period of time,
In addition, many countries have their own national innovation agenda specifically focusing on biomedical research. Perhaps the most striking finding of this analysis is the similarity found across countries in terms of policies
America innovative biopharmaceutical companies face increasing challenges, ranging from the cost and increased complexity of bringing new medicines to patients, the prospect of attracting
and sustaining the capital needed to develop tomorrow new treatments and cures, the increasing uncertainty related to coverage and payment of innovative medicines,
and it could revolutionize medicine TED Conference/Flickrmanu Prakash with the Foldscope, a microscope made almost entirely of paper.
For a whole lot of people, especially those in developing countries, science and with it, medicine isn readily available to the majority of citizens.
#Smartphone skin cancer app developed by Vancouver dermatologist A new smartphone app for monitoring skin cancer made its debut at the World Congress of Dermatology in Vancouver on Tuesday.
"Dr. Susan Poelman, a dermatologist at the University of Calgary, says the device could help solve problems in her own clinic."
#Smartphones tested as tools for medical research Jody Kearns doesn't like to spend time obsessing about her Parkinson's disease.
Smartphone Medicine Dr. Michael Mcconnell, a cardiologist who's using an app to study heart disease,
Scientists overseeing the studies say the apps could transform medical research by helping them collect information more frequently and from more people, across larger and more diverse regions,
"said Dr. Michael Mcconnell, a Stanford university cardiologist, who's using an app to study heart disease."
Google Inc. says it's developing a health-tracking wristband specifically designed for medical studies.
But if smartphones hold great promise for medical research experts say there are issues to consider
Democratizes medicine Apple had created previously software called Healthkit for apps that track iphone owners'health statistics and exercise habits.
and helping to democratize medicine, "Williams said in an interview. Apple launched its Researchkit program in March with five apps to investigate Parkinson's, asthma, heart disease, diabetes and breast cancer.
a University of Rochester neurologist who's leading the Parkinson's app study called mpower.""Participating in clinical studies is often a burden,
"None of the apps test experimental drugs or surgeries. Instead, they're designed to explore such questions as how diseases develop
and will travel all around town neighborhoods, shopping centers, medical complexes, recreation areas, etc. They can seat 16,
Cardiovascular surgeons at Miami Children's Hospital turned to 3d printing to print out a scale replica of a 4-year-old girl's heart
so they could plan for a complicated surgery to save the girl's life. She suffers from a congenital condition called anomalous pulmonary venous connection (TAPVC)
After a few band-aid surgeries that proved to be temporary fixes doctors knew they needed to come up with a solution.
Using the 3d-printed model the doctors were able to plan a surgery that hadn't been performed before using parts from a donor heart
The story recalls a couple of other similar cases such as one at Morgan stanley Children's Hospital of New york-Presbyterian where last year doctors also practiced a complex heart surgery on a 3d model before operating on a baby
. 3d printing adds another element in caring for extremely complex conditions where surgical intervention is thought not typically possible pediatric cardiologist Nancy Dobrolet said in a release.
In Adanelie's case the 3d model provided us with way to create a surgical option for her survival.
#Lab-grown human muscle is a medical breakthrough The new kind of lab-grown muscle will allow the study of disease
"One of our goals is to use this method to provide personalised medicine to patients,
This opens up new therapeutic possibilities for patients suffering from neurological trauma or disorders particularly individuals who have become paralysed following spinal cord injury.
or who aren't suitable for more drastic gastric bypass surgery. They are not currently available on the NHS.
Each device is configured to the patient according to hearing tests with an audiologist. The idea is that the brain gradually begins to play down the illusory sounds of tinnitus
senior audiologist at charity Action On Hearing loss, says:''We welcome all new research, as the mechanisms behind this debilitating condition are still not fully understood
the technology can also be used in real-world applications, such in medicine, education, virtual tourism and for conferences.
for use in medical research. he technology will leverage Organovo proprietary Novogen Bioprinting Platform and Lreal expertise in skin engineering to develop 3d printed skin tissue for product evaluation and other areas of advanced research,
donated by plastic surgery patients. Adam Friedmann, a consultant dermatologist at the Harley Street dermatology clinic, told the BBC:
think the science behind it-using 3d printing methods with human cells-sounds plausible. can understand why you would do it for severe burns or trauma but
This enables doctors to measure fluid pressure in the skull-known as intracranial pressure (ICP)- without the need for surgery or painful spinal procedures.
And surgery to insert the lens takes just eight minutes, with sight being restored in seconds.
He explained that surgery to implant the lens into the patient's eye takes eight minutes
'And he continued it was'as painless and gentle'as cataract surgery. Visual acuity-or the ability to see fine spatial details-is measured typically with a Snellen chart used by optometrists globally.
since the 1970s a warning that has divided long the medical establishment. A growing number of experts have been arguing there is no link between high cholesterol in food and dangerous levels of the fatty substance in the blood.
US cardiologist Dr Steven Nissen, of the Cleveland Clinic, said:''It's the right decision.
'London-based cardiologist Dr Aseem Malhotra, science director of campaign Group action On Sugar, wrote in The british Medical Journal that it was time to'bust the myth of the role of saturated fat in heart disease'.
Dr Daniel Weiss, an organ regeneration expert at the University of Vermont College of Medicine in Burlington, said:'
'Researcher Dr Harald Ott of the Massachusetts General Hospital Department of Surgery said:''We are focusing on the forearm and hand.'
#Medical cannabis DOESN'T ease pain, nausea, vomiting, sleep disorders or Tourette's By Lizzie Parry for Mailonline Published:
Medicinal cannabis has been legalised in 23 US states as a therapy to treat disease or alleviate symptoms,
500 volunteers, found the evidence supporting the use of medical cannabis is weak. It found moderate-quality evidence to support the use of cannabinoids-chemical compounds that are the active principles in marijuana-for the treatment of chronic pain.
and her team evaluated the evidence for benefits and adverse events, related to medicinal cannabis use.
In addition, Dr Whiting and her team found weak evidence to support the claim that medicinal cannabis has no effect on psychosis,
'says Dr. Barbara Sherman, a clinical professor of behavioural medicine. Much of the technology comes off the shelf
beating heart-and say it could revolutionise medicine. The new hearts will allow new drugs to be tested,
who is co-senior author of the study with Dr. Bruce Conklin, a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco.'
Surgeons at Manchester Royal Eye Hospital implanted a chip at the back of Mr Flynn eye in a four-hour procedure last month.
Surgeons will now insert the Argus II retinal implant into more patients over the coming months to demonstrate that it can work for a variety of patients.
Professor Paulo Stanga, consultant ophthalmologist at the Manchester Royal Eye Hospital, said: r Flynn progress is truly remarkable.
developed by US firm Second sight Medical Products, might be used for patients with other vision problems.
that are shipped as liquids in pods that are placed into the machine prior to each job. the team consists of marcus foley, aaron rowley both biomedical/mechanical engineers and joseph white,
The device uses a method called electro-acupuncture (EAV), a traditional technique for measuring vitamin and mineral levels.
EAV is a form of acupuncture where a small electric current is passed between pairs of electrodes.
it like going to the dentist and having your mouth numbed. It very hard to speak without somatosensory feedback,
#Imec Milab medical game-changer Imec and John Hopkins University of Baltimore have delivered a ame-changer in healthcarewith a chip-based technology called Milab
and blood cells. ilab will bring a revolution in medical diagnostics, says Imec CEO Luc van den Hove,
It replaces expensive medical testing equipment which can take days to deliver results. The technology will be commercialised by a company called Midiagnostics backed by Flemish investors Marc Couke and Michel Akkermans, Flemish investment company PMV and Imec.
He believes cognitive technologies could eventually automate everything from reviewing medical X-rays to commodities trading. he potential goes way beyond automating repetitive tasks,
#This MIT Grad Is Changing Medicine With a Needle-Covered Pill While medical injections are unpleasant and inconvenient, theye also necessary for people with illnesses like diabetes.
But that might not be true for too much longer. Carl Schoellhammer, 28, has created a pill that would render syringes unnecessary.
freeing the needles to introduce the medicine. Once the drugs are delivered, the capsule can pass through the body safely.
a handheld device inserted suppository-style that uses ultrasound waves to push medicine into the tissues of the GI TRACT.
This allows the body to absorb the medicine faster. Schoellhammer sees this being helpful for the 1 million people in the United states who have irritable bowel syndrome (IBS) as well as other conditions.
and his data is sent to his hospital and medical team, if there is any indication of a problem the doctors identify it
Professor Martin Cowie is a Cardiologist ith some patients it very tricky to get the balance right.
and at a faster speed, would make a big difference in medicine. Targeted treatments could come sooner
#21st-century medicine: Gauss guns, magic bullets, and magnetic millibot surgeons Sometime around the turn into the 20th century,
medical extraordinaire Paul Ehrlich coined the word zauberkugel or agic bulletto describe new drugs he was working on to cure syphilis and cancer.
In theory, such drugs would leave healthy tissue intact while targeting only the diseased. Psychologists later appropriated this term to describe the phenomenally widespread panic that ensued
The operators don even sit in the surgical amphitheater, but rather run the show from a separate control room.
remote robotic surgery will have entered a new era. Some time ago, we discussed some of the finer points of installing
#Terapio autonomous medical robot can assist nurses Japan has a rapidly aging population, along with the longest life expectancy in the world.
a medical robotic assistant that relieves nurses from some of the mundane tasks of collecting patient data and vital signs.
A camera would allow for remote viewing by the medical staff. Toyohashi University professor Ryosuke Tasaki says,
could make flu shot obsolete Influenza is no longer the scourge it once was thanks to modern medicine,
Endocrinologist Anoop Misra told Times of India that diabetes was an escalating problem in India
In medicine you talk of drug delivery-we do flavour delivery."."The sensory profile of Douxmatok is literally the same as sugar."
and added that it has found no evidence that that medical information such as insurance claims and test results was targeted
identity or medical and financial fraud, explained Rob Sadowski, director of technology solutions at security specialist RSA,
from oncological research to education. This latest collaboration makes Watson somewhat more tangible to the average person,
to help oncologists find targeted diagnoses. In each of these cases, Watson reads and understands more and more of the published literature
and work with prior to surgery, according to the researchers. GHOST researchers are also working with sponges
says co-principal investigator Michael R. Bruchas, associate professor of anesthesiology and neurobiology at Washington University in St louis. ith one of these tiny devices implanted,
a long-term ongoing epidemiological study conducted by the University of Michigan. Lanza and her team focused on information reported about the rates of use of three different substanceslcohol, cigarettes,
and observe and study the biological and medical significance of RNA misregulation. Previous technologies made it possible to attain static snapshots of RNA location
Mirkin is professor of chemistry in the Weinberg College of Arts and Sciences and professor of medicine, chemical and biological engineering, biomedical engineering and materials science and engineering.
professor of biomedical surfaces at University of Nottingham. hat we are doing here is paving the way for the manufacture of stem cells in large numbers
which eliminates a protein that regulates electrical signals in the brain and causes a host of behavioral, neurological,
#Bacteria build#coat#for medical implants Artificial implants, like pacemakers, can spark the body defenses and cause complications, even rejection.
or coat medical implants in 3d micro-structures, which can make the implants more biocompatible.
Until now, however, it hasn been possible to apply these surface structures to one of the most promising materials in the field of medicine:
a professor of food and nutrition toxicology at ETH Zurich, has succeeded for the first time in amplifying gene samples containing DNA ADDUCTS
a professor of orthopedic surgery at the University of Missouri School of medicine. he benefit to patients is that more graft material will be available
This will allow us as surgeons to provide a more natural joint repair option for our patients.
donated tissues are stored within a medical-grade refrigeration unit in sealed bags filled with a standard preservation solution.
says study coauthor James Cook, director of the Comparative Orthopedic Laboratory and the Missouri Orthopedic Institute Division of Research. ith the traditional preservation approach,
schedule surgery and get the graft to the surgeon for implantation. METAL IMPLANTS VS. TISSUE GRAFTS Stannard says that patients with metal and plastic implants often are forced to give up many of the activities they previously enjoyed
However, the method of preserving the grafts themselves has limited the amounts of quality donor tissue available to surgeons. 100%USABLE AT 60 DAYS Additionally, because of testing requirements and logistics,
says medical entomologist Gregory Lanzaro, professor in the pathology, microbiology and immunology department at University of California,
professor of psychiatry at University of Iowa. o it really providing a new picture and new insight into the composition and function of the brain in bipolar disease.
The study is the first time this MRI technique has been used to investigate a psychiatric disease. One reason researchers didn know that the cerebellum might be important in bipolar disorder,
postdoctoral researcher and first author on the study that is published in the journal Molecular Psychiatry. ur study was essentially exploratory.
and a new indication for teduglutide, pediatric SBS. NPS Pharma is now conducting a global study for teduglutide in pediatric patients with SBS who are dependent on parenteral support.
NPS has licensed several of its products through partnerships with several biopharma giants. Amgen markets cinacalcet HCL as Sensipar in the U s. and as Mimpara in the EU;
In the future, neurosurgery may be combined with molecular biology to deliver positive clinical outcomes and perhaps treat conditions like spinal cord or nerve injuries,
"While biomedical researchers have had some successes in repairing peripheral nerves and nerve clusters outside the brain and spinal cord in humans,
Telomerase is an almost universal oncology target, yet there are few telomerase-directed therapies in human clinical trials,
and $3 billion to sequence the first human genome,"notes Peter White, Ph d.,principal investigator and director of the biomedical genomics core at Nationwide Children's and the study's senior author."
%"At Nationwide Children's we have a strategic goal to introduce genomic medicine into multiple domains of pediatric research and healthcare.
The results from this study, published today in JAMA Psychiatry in an article entitled ole of Translocator Protein Density,
Unlocking the underlying mechanisms of host barrier permissiveness to microbes is critical to understanding the etiology of many infectious diseases.
The results from this study were published today in the Journal of Experimental Medicine within an article entitled I3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes Listeria relies on two surface proteins called
A committee of the Institute of Medicine (IOM) yesterday called for the sharing of supporting data for clinical trials results within six months after publication, with a full analyzable data set shared no later than 18 months
professor of medicine and leader of the YODA Project. e hope this action serves as a catalyst to others to join the momentum on open science.
The European Medicines Agency in October issued a more expansive data sharing policy last October, though not the full open-access sought by advocates.
director at the National Institute of Biomedical Imaging and Engineering who helped find the current study."
"said senior author Mehmet Toner, Ph d.,professor of surgery and health sciences and technology at Harvard Medical school,
Thousands of times thinner than the average human hair, nanofibers are used by medical researchers to create advanced wound dressings and for tissue regeneration
"says Geoff Woods, M d, from the Cambridge Institute for Medical Research at the University of Cambridge,
Toronto and senior author on the study. hese sub-types may be important to determining the response to surgery or radiotherapy between patients."
when oncologists at Memorial Sloan-Kettering Cancer Center (MSK) refused to prescribe Zaltrap (ziv-aflibercept) for metastatic colorectal cancer due to its initial $11, 000-per-month cost.
Genentech provided its medicines to more than 180,000 people last year for free or reduced cost. Willson noted that the Genentech Access to Care Foundation recently changed its financial criteria with the goal of helping more people, n recognition of the changing healthcare environment and the increasing number of people with high out
e understand that the cost of medicines can be challenging for some patients, Novartis said. he majority of CML patients in the U s. pay less than $100 out of pocket per month for our CML treatments,
and we are committed to ensuring that patients have access to their medicines. To that end, Novartis said,
its patient assistance program provides the company medicines for free or at a reduced cost to those who can afford them,
The company CML medicines have been provided free to an average of 5 000 uninsured or underinsured patients in the U s. annually for the past six-and-a-half yearsore than $1 billion in free medicine. ecause the cost of drugs is one of the few transparent healthcare costs,
drugs get much public attention, yet are only a small percentage of spending and demonstrate remarkable rewards,
yet developers can win payer approval for a costlier medicine by agreeing to allow limited-time use,
or at least slow the progression of such neurodegenerative diseases as ALS, Alzheimer's, Parkinson's, and Huntington's diseases.
associate dean of oncology programs at UT Southwestern Medical center and co-author on the current study.""We propose that SW033291 will be useful in accelerating recovery of bone marrow cells following a bone marrow transplant
said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
and toxicology in UB's School of medicine and Biomedical sciences. The study found that by manipulating the activity of Activin receptors the researchers were able to increase
or sensory recovery, said Hua-Zi Xu, M d.,department of spinal surgery, the second affiliated hospital of Wenzhou Medical University.'
'Most of the patients exhibited improvements within the first 12 to 24 months after surgery and their functional recovery slowly increased,
but plateaued at 24 months after surgery. Overall, wrote the researchers, there appeared to be a reater improvement in sensory function rather than motor function in the ASIA score assessment.
the quality and quantity of transplants, surgical technique, and postoperative rehabilitation, continued the researchers.''We believe that to derive clinical benefits from OEC transplants a combination with other pharmacological agents is most likely to achieve significant axon regeneration
"Our study has great biological and medical significance, particularly in light of the huge disease burden of malaria,"explained senior author Manoj Duraisingh, Ph d.,professor of Immunology and Infectious diseases at the T. H. Chan School of Public health."
#Depersonalized Medicine Shows Promising Results Against Cancer Researchers at St louis University (SLU) say they have,
Unlike recent advances in personalized medicine that focus on specific genetic mutations associated with different types of cancer,
. associate professor of neurosurgery and vice-chair of research and academic development at UC San diego School of medicine.
such as those of the breast and bladder, according to Stephen Royle, Ph d.,team leader and associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school."
even though the American Society for Reproductive Medicine holds that infertility is due in equal measure to male and female factors.
The scientific team presented their results July 8 in Science Translational Medicine, in an article entitled,
noted the authors of the Science Translational Medicine article. According to Dr. Krawetz, the diagnostic potential of next-generation sequencing of sperm RNA indicates this method is suited"better to the task"of analyzing the male's role in infertility,
and is a step toward personalized precision reproductive medicine that may help guide the couple to their successful treatment.
The technique could become part of a routine examination as"we move toward personalized and precision medicine,"Dr. Krawetz asserted.
it requires medical personnel with technical skills and brings the risk of needle-related diseases and injuries.
It is also easy to use without the need for trained medical personnel, making it ideal for use in developing countries,
. professor of molecular and cellular oncology at MD Anderson Cancer Center. ut exactly how this occurs has not been understood fully.
It will be maintained as the source of all cells used to produce the company drug through preclinical and clinical testing and then into commercial sale.
The Sierra leone Trial to Introduce a Vaccine against Ebola (STRIVE) Phase III study being conducted by the Sierra leone College of Medicine and Allied Health Sciences, Sierra leone Ministry of Health,
Major funding for these studies has come from sources that include the U s. Department of defense Defense Threat Reduction Agency and Joint Vaccine Acquisition Program, the U s. Department of health and Human Service Biomedical Advanced Research Development Authority,
advancing efforts to create blood for surgery and treat leukaemia and other cancers. His latest work continues in this same vein,
and make the main cell types of neurological systems-the central nervous system and the peripheral nervous system-in a dish that is specialized for each patient,
when used in the less advanced stages of the cancer, suggesting that T-VEC could prove a valuable early treatment option for skin cancers that are unable to be removed by a surgeon.
The drug has been submitted to both the US Federal Drug and Food administration and the European Medicines Agency for consideration, with the scientists hopeful of winning approval later this year.
The findings were published in the Journal of Clinical Oncology y
#Ballistic wallpaper to help protect soldiers seeking temporary shelter It sounds like an old Goon Show joke,
The fruit fly (or Drosophila) is one of the most important model organisms used in biomedical research it's easy to care for
This involves a surgeon implanting electrical leads into the region of the brain that controls movement.
and not all patients qualify for the surgery. We asked if there was a way to provide the same treatment in a less invasive way that doesn't require brain surgery."
"From there, the students learned about an experimental clinical treatment called transcranial direct current stimulation, which involves low-level current being passed through electrodes on a patient's head.
This unprecedentedly high graphene composition means that the oft-praised electric and mechanical properties of graphene might soon find their way into all kinds of macroscopic 3d-printed creations, with important consequences for the electronics and biomedical fields (among many others.
according to the scientists involved, makes the objects printed with this ink highly flexible and safe for biomedical applications.
The ability to tune the elasticity of the material at will could prove important in manufacturing biomedical polymers that can,
paving the way for these materials to be used for biodegradable sensors and medical implants. But the applications of a highly-conductive graphene ink could be
#Elastic, wound-healing hydrogel activated by light Hydrogels have huge potential in the field of biomedicine,
The scientists say that more preclinical studies are required to test the gel's properties and safety before human trials will be possible.
the hardware inside is starting to show huge promise in the world of medical diagnostics,
which could be used to improve night-vision technology, biomedical imaging, and high-speed telecommunications. The team next plan to build
#Mussel-inspired surgical glue shuts down bleeding wounds in 60 seconds The ability of mussels to stubbornly bind themselves to underwater surfaces has intrigued scientists for years.
A team of Korean scientists has developed now a surgical glue inspired by these natural wonders that's claimed to be cheaper,
In surgery, stitches and staples are very effective at binding body tissue together, but they can cause scarring
mussel protein-based adhesive (LAMBA) and claim to have proven its superiority to existing surgical glues.
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