Professor of Biomedical Surfaces in the School of Pharmacy and Chris Denning, Professor of Stem Cell biology in the School of medicine and funded by the Engineering and Physical sciences Research Council (EPSRC).
#A'nanomachine'for surgery with no incision (Nanowerk News) A surgical operation has long been considered one of the first options in cancer treatment;
The realization of surgery with no incision (chemical surgery) by nanomachine allows us to anticipate outpatient treatment with no need of hospitalization n
says study leader Bjrn Hgberg from the Department of Medical Biochemistry and Biophysics at Karolinska Institutet.
In particular, biomedical applications, an area where the use of biocompatible polycarbonates is established well, have been left out.
for example, could provide many more possibilities for biomedical applications n
#New material opens possibilities for super-long-acting pills (Nanowerk News) Medical devices designed to reside in the stomach have a variety of applications,
which is a medical emergency potentially requiring surgical intervention, says Koch Institute research affiliate Giovanni Traverso,
a professor of medical science and engineering at Brown University who was not involved with this study.
#Technology helps personalized medicine, enabling epigenomic analysis with a mere 100 cells A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation,
This epigenomic characterization potentially allows medical doctors to create personalized treatment of diseases, by understanding the state of a patient,
and medical skills was also extremely important, as many people suffered injuries from being hit by debris in flood waters.
Published in the peer-reviewed journal Pediatrics, the paper looked at the prevalence of hospitals
Epidemiologist Dr. Jennifer Nelson, M d, . and her colleagues evaluated data from the Maternity Practices in Infant Nutrition and Care survey,
and the connection to community support,"adds Dr. Lori Feldman-Winter, a professor of pediatrics at Cooper University Hospital in New jersey,
These and similar findings have been dismissed by the modern medicine industry because of the lack of patentability.
Additionally, how can they validate years of cutting into patients via invasive surgery and putting patients on the conveyer belt of radiation
Just as with chronic inflammation, modern medicine has accused the immune system as having gone awry and as the primary source of most problems associated with that process.
The world's poster child for corporate manipulation and deceitextreme bias at Wikipedia on homeopathic medicineguatemalan STD medical experiments were just one crime in a long history of medical-government collusion to use humans
But medical microbiologist Timothy Walsh of Cardiff University, UK, urges caution because the drug has been tested against only a small number of lab strains.
On top of brainwave monitoring, Jaguar land rover is also assessing how a vehicle could monitor the well-being of the driver using a medical-grade sensor embedded in the seat of a JAGUAR XJ.
Through a clinical collaboration between Caltech, Keck Medicine of USC and Rancho Los Amigos National Rehabilitation Center, the now 34-year-old Sorto is the first person in the world to have a neural
the clinical trial was led by principal investigator Richard Andersen, the James G. Boswell Professor of Neuroscience at Caltech, neurosurgeon Charles Y. Liu, professor of neurological surgery, neurology,
and neurologist Mindy Aisen, chief medical officer at Rancho Los Amigos. Andersen and his colleagues wanted to improve the versatility of movement that a neuroprosthetic can offer to patients by recording signals from a different brain region other than the motor cortex, i e.,
The Surgery The surgical team at Keck Medicine of USC performed the unprecedented neuroprosthetic implant in a five-hour surgery on April 17, 2013.
everything about the surgery was different: the location, the positioning and how you manage the hardware.
which is determined largely at the time of surgery. The USC Neurorestoration Center primary mission is to leverage partnerships to create unique opportunities to translate scientific discoveries into effective therapies. e are at a point in human research where we are making huge strides in overcoming a lot of neurologic disease,
says neurologist Christianne Heck, associate professor of neurology at USC and co-director of the USC Neurorestoration Center. hese very important early clinical trials could provide hope for patients with all sorts of neurologic problems
that involve paralysis such as stroke, brain injury, ALS and even multiple sclerosis. The Rehabilitation Sixteen days after his implant surgery, Sorto began his training sessions at Rancho Los Amigos National Rehabilitation Center,
where a computer was attached directly to the ports extending from his skull, to communicate with his brain.
The rehabilitation team of occupational therapists who specialize in helping patients adapt to loss of function in their upper limbs
says that advancements in prosthetics like these hold promise for the future of patient rehabilitation. e at Rancho are dedicated to advancing rehabilitation and to restoration of neurologic function through new technologies,
also a clinical professor of neurology at the Keck School of medicine of USC. his research is relevant to the role of robotics and brain-machine interfaces as assistive devices,
We have created a unique environment that can seamlessly bring together rehabilitation, medicine, and science as exemplified in this study.
developed at the Applied Physics laboratory at Johns Hopkins. Sorto was recruited to the trial by collaborators at Rancho Los Amigos National Rehabilitation Center and at Keck Medicine of USC.
Keck Medicine of USC team members include Brian Lee, Christianne Heck, Sandra Oviedo, Paul Kim,
says lead author Dr Andrew Pocklington from Cardiff University MRC Centre for Neuropsychiatric Genetics and Genomics. ur study marks a significant step towards understanding the biology underpinning schizophrenia,
Researchers studying psychiatric disorders have suspected previously that disruption of this balance contributes to schizophrenia. The first evidence that schizophrenia mutations interfere with excitatory signalling was uncovered in 2011 by the same team,
based at Cardiff University MRC Centre for Neuropsychiatric Genetics and Genomics. This paper not only confirms their previous findings,
Zlokovic and his research team have studied the cellular and molecular mechanisms of brain blood vessels that maintain normal cognition with hopes of developing new treatments for Alzheimer and other neurodegenerative diseases.
By performing a neuropathological study in humans with Alzheimer and using transgenic animals to model the disease,
and Age Related Neurodegeneration The process that allows our brains to learn and generate new memories also leads to degeneration as we age, according to a new study by researchers at MIT.
a professor of genetics and neurology at Harvard Medical school who was involved not in the research. he work elegantly links DNA strand break formation by the enzyme topoisomerase IIß to the temporal control of transcription,
and treat everything from neurodegenerative disorders to paralysis. Sounds unlikely, until you visit Charles Lieber lab. Led by Lieber, the Mark Hyman Jr.
or record neural activity. hese type of things have never been done before, from both a fundamental neuroscience and medical perspective,
or at least slow the progression of such neurodegenerative diseases as ALS, Alzheimer, Parkinson and Huntington diseases.
10.1038/ncomms8319abstractneurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neuronsamyotrophic lateral sclerosis (ALS) is a neurodegenerative disease thought to employ cell nonautonomous
and drives progressive neurodegeneration. eurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neuronsby Julie Vérièpe, Lucresse Fossouo and J Alex
Brain surgery is famously difficult for good reason: When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible
while keeping crucial brain tissue intact and visually distinguishing the two is often impossible. Now Johns Hopkins researchers report they have developed an imaging technology that could provide surgeons with a color-coded map of a patient brain showing
which areas are and are not cancer. A summary of the research appears June 17 in Science Translational Medicine. s a neurosurgeon,
I in agony when I taking out a tumor. If I take out too little the cancer could come back;
says Alfredo Quinones-Hinojosa, M d.,a professor of neurosurgery, neuroscience and oncology at the Johns hopkins university School of medicine and the clinical leader of the research team. e think optical coherence tomography has strong potential for helping surgeons know exactly where to cut.
First developed in the early 1990s for imaging the retina, optical coherence tomography (OCT) operates on the same echolocation principle used by bats and ultrasound scanners,
thought OCT might provide a solution to the problem of separating brain cancers from other tissue during surgery.
and the surgeon could look at a screen to get a continuously updated picture of where the cancer is
the team has tested the system on fresh human brain tissue removed during surgeries and in surgeries to remove brain tumors from mice.
The researchers hope to begin clinical trials in patients this summer. If those trials are successful
it will be a big step up from imaging technologies now available during surgeries, says Quinones-Hinojosa. ltrasound has a much lower resolution than OCT,
She is working on combining OCT with a different imaging technique that would detect blood vessels to help surgeons avoid cutting them s
how we develop the next generation of medications for chronic painhich is by far the most prevalent human health conditionnd the way we execute basic biomedical research using mice. esearch has demonstrated that men
The discovery comes as there is increased attention to the inclusion of female animals and cells in preclinical research.
and cell lines in preclinical research . or the past 15 years scientists have thought that microglia controlled the volume knob on pain,
this work provides a novel conceptual framework for further studies aimed at identifying the molecular underpinnings of neurodevelopmental disease and psychiatric illness. pecifically,
and reacts to changes in the environment can help us to find new ways to treat neurodegenerative diseases and mental illness. ource:
and Surgical Center for Retina developed software that detects eye diseases such as diabetic macular edema using a smartphone.
The software was developed in collaboration with biomedical engineers from the ITESM and uses the camera of the phone to detect any abnormality in the thickness of the retina. he idea is to detect
says Dr. Juan carlos Altamirano Vallejo, medical director of the Medical and Surgical Center for Retina.
even without in depth knowledge of ophthalmology, can, with this tool, detect certain abnormalities and send the patient to the specialist. sing the software will reduce costs
where expertise areas such as ophthalmology have not arrive yet because equipment to detect these diseases are expensive and so far only the visiting specialist can do this kind of diagnosis. t will help those that
and Surgical Center for Retina is a small company with just ten employees dedicated to ophthalmology and retina special medical care.
It it also dedicated to biomedical and pharmaceutical research, to develop diagnostics and equipment, applicable to society. e want to give back to our community everything it gives to us,
#Novel Disease Gene Linked to Neurodegenerative Disorders Identified Researchers at the University of Miami (UM) have discovered
the implications encompass all forms of neurodegeneration including Lou Gehrig and Parkinson Diseases. Mitochondria constantly undergo fusion
these genes could be involved in common pathological mechanisms of neurodegeneration, the study says. his finding builds on our discovery of MFN2 as a major disease gene in this area over 10 years ago,
The study was is published in the Journal of Clinical Oncology and included 436 patients all of whom had aggressive malignant melanoma.
people undergoing brain surgery have had their somatosensory cortex stimulated and reported feeling things such as"a wind rushing over my hand
"says Daniel Weiss at the University of Vermont College of Medicine in Burlington, who works on lung regeneration."
and in the guts of premature babies. In 2013, Chang put his assassins through their paces in a lab flask.
The disease is identified only in time for curative surgery in about 15 per cent of people
relieve pain and perhaps help male infertility and other medical conditions. The curious healing effect has been known for decades researchers have been investigating its use in eye injuries
A better understanding of how red light affects cells should make it easier to expand its medical uses,
nor is there evidence at this time that medical information such as claims, test results, or diagnostic codes were targeted
vaccine or medicine,"says Dr. Marie-Paule Kieny, assistant director-general for health systems and innovation at the World health organization,
#The Future Of Cardiology Will be shown In 3-D How can you tell the difference between a good surgeon and an exceptional one?
"The handful of the top surgeons in the world are said like sculptors Dr. Deepak Srivastava, a director at the Gladstone Institute of Cardiovascular disease in San francisco."
"When cardiovascular surgeons go in to repair a defect in the heart, their success is so often dependent on an ability to see the anatomy in 3-D in their minds,
"That's more difficult for younger, less experienced surgeons.""But recent advancements in the field of computer-based modeling may make it easier someday for good surgeons to be great.
One such technology comes from Dassault systèmes, a French company that specializes in 3-D software to help engineers who design cars
and test all the possibilities before a heart surgery,"said Dr. Steve Levine, chief strategy officer and director for the Living Heart Project.
The technology hasn't received regulatory approval for doctors to use it in making medical decisions.
"Challenges to greater adoption of computer-modeling include a lack of data for some medical conditions,
At the University of California, San francisco, a team of researchers in the cardiology division are hoping to use the Living Heart Project to figure out the best time to replace patients'heart valves.
Surgeons have to strike the right balance between swapping out too early, when a valve is still working reasonably well,
But he isn't convinced it will transform how are surgeries are performed.""Is this a hammer looking for a nail?"
"Or will this change how we practice medicine?""He said he hopes advanced technology can fill some gaps,
where surgeons are still making educated guesses, such as the timing of valve replacements. But he also said he hasn't seen a convincing study yet that proves the simulation can improve patient outcomes.
and is said to be suitable for a wide range of endoscopic devices from bronchoscopes for lung examinations to laparoscopes used in keyhole surgery applications."
"This camera module has been designed specifically for medical applications with stringent bio-compatibility, sterilization and electrical requirements,"said Shingo Ishii, group leader of the medical business development division at Fujikura.
He adds that the module very small footprint and power efficiency are critical features for such applications,
and optical micro-assemblies designed specifically for small CMOS-based medical camera systems. The company also showed off the innovation at last week Medical Design and Manufacturing (MD&M) event
but the firm has been touting the medical sector as one that is ripe for growth. Tehzeeb Gunja, one of its senior marketing and business development managers, said of the Fujikura/POC collaboration:"
-and using less light than some existing infrared-based alignment procedures-the principles behind eyeselfie could also now be extended outside ophthalmology and into other sectors.
Traditional systems, including applications found outside ophthalmology in head-mounted displays, have tried to enlarge the eye box
Within ophthalmology, self-imaging would allow patients to take retina photos in their own home,
We anticipate that our terahertz device will have applications in personal security, scanning and various medical sectors.
but a new number published today in the medical journal The Lancet may be even more significant.
Ossur's Orthopedic surgeon and director of research and development, Thorvaldur implanted the tiny sensors into the residual muscle tissue of two amputees that they said is responsible for triggering the movement in the prosthesis via a receiver.
which develops medical technology for use in patients s
#Researchers develop new Algorithm to empower Robots to Learn like Humans New algorithms enable robots to learn motor tasks through trial and error, like humans.
which were presented at the American Society of Clinical Oncology. Lung cancer, which is also known as carcinoma of the lung,
a number of patients are found unsuitable for surgery due to their smoking-related diseases. Nivolumab is among the set of drugs known as heckpoint inhibitorsthat are developed by a number of pharmaceutical companies.
According to Ian Lipkin, a professor of epidemiology and director of the Center for Infection and Immunity at Columbia University
3-D imaging at cellular resolution in behaving organisms is a new frontier for biomedical and neuroscience research,
The preclinical and intravital molecular imaging system houses a window for tissue observation in addition to a larger imaging chamber.
2015 Optical coherence tomography (OCT) holds promise for guiding surgeons as they operate on brain tumors and help them avoid removing healthy tissue.
and the surgeon could look at a screen to get a continuously updated picture of where the cancer is
So far the system has been tested on fresh human brain tissue removed during surgeries and in surgeries to remove brain tumors from mice.
The researchers hope to begin clinical trials in patients this summer. Neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible
while keeping crucial brain tissue intact. Visually distinguishing the two is often impossible.""As a neurosurgeon,
I'm in agony when I'm taking out a tumor, "said Dr. Alfredo Quinones-Hinojosa, a professor of neurosurgery, neuroscience and oncology at the Johns hopkins university School of medicine and the clinical leader of the research team."
"If I take out too little, the cancer could come back; too much, and the patient can be disabled permanently.
We think optical coherence tomography has strong potential for helping surgeons know exactly where to cut."
"Optical coherence tomography that could help surgeons differentiate a human brain tumor, red, from surrounding noncancerous tissue, green.
/Johns Hopkins Medicine. First developed in the early 1990s for imaging the retina, OCT operates on the same echolocation principle used by bats and ultrasound scanners,
it will be a big step up from imaging technologies now available during surgeries, Quinones-Hinojosa said."
She is working on combining OCT with a different imaging technique that would detect blood vessels to help surgeons avoid cutting them.
The research was published in Science Translational Medicine (doi: 10.1126/scitranslmed. 3010611. For more information, visit www. hopkinsmedicine. org.
visit www. indigo-clean. com and www. strath. ac. uk. Biophotonics Market Poised for Growth Top Biophotonics Stories of 2014 Ophthalmology Devices Market Set to
"The results of a pilot clinical study, carried out at the Leeds Institute of Cardiovascular and Metabolic Medicine under the supervision of professor Peter Grant,
a biomedical and health care technology group specializing in commercializing technologies from universities and research institutes.
Able to rapidly process very large amounts of biomedical imaging data, the system addresses what has been a major bottleneck in pharmaceutical development, according to a team of researchers from the U s. and Australia.
"Multispectral imaging is used for many types of medical research and not only produces an image but also provides data about the specific colors within that image.
and many require complex surgery, such as transplanting muscle tissue or implanting electrodes in a subject's brain.
And the surgery to implant the sensors was minimal. According to Thorvaldur Ingvarsson, an orthopedic surgeon and head of R&d at Ossur, the procedure took 15 minutes,
and each sensor required a single-centimeter-long incision. The tiny sensors (3 millimeters-by-80 millimeters) are powered by magnetic coils embedded in the socket--the cushioned,
#Handheld Device For Surgeons Could Turn off Pain A new handheld tool called the Chimaera will help surgeons find the right nerve with ease by giving them real-time feedback during operations.
This kind of device, its developers claim, will usher in a new age of surgical devices, making delicate nerve procedures easier for surgeons everywhere.
In recent years surgeons have been able to implant devices called neuromodulators that can stop pain
But surgeons have a hard time accessing nerves that are behind the eyes or the face because it's difficult to identify the right one among the jumble,
The Chimaera device helps surgeons identify and access specific nerves. When a surgeon holds the wireless wand-like device near a place where he plans to make an incision,
the Chimaera sends data about that spot to a computer where it is combined with information from a CT SCAN of the patient brain taken previously.
This information is compiled into a single X-ray-like image that the surgeon can see in real time with Google glass
and nerves that surround the place of the incision so that the surgical tool is as precise as possible.
the Chimaera can help the surgeon damage as little as possible on its way to the desired nerve,
where the surgeon can implant the neuromodulator device. Right now these most delicate procedures can only be conducted by a handful of surgeons worldwide, Reuters reports.
But the Chimaera could make neuromodulators so much easier to implant that they could become more commonplace.
what will likely be many devices that give surgeons more feedback during a procedure, which will make surgery easier and more precise o
#Approved: Prosthetic Legs That Anchor Directly To The Bone The FDA has approved just leg prosthetics that anchor directly to the bone,
A 2014 study published in Physical Medicine and Rehabilitation found that amputees using the device reported increased mobility,
without the use of surgery, they helped people with severe paralysis voluntarily move their legs something that's never been accomplished before.
Earlier this year, Edgerton and another group of researchers were able to allow partially paralyzed patients to move their legs on their own using a new treatment that didn require a surgical implant.
and the almost 1. 3 million who have spinal cord injuries. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
said Roderic Pettigrew, director of the National Institute of Biomedical Imaging and Bioengineering, the organization that funded the study, in the UCLA press release.
According to the press release, Edgerton thinks this new approach could be more accessible to patients as it doesn require surgery
But in an extremely promising medical advance, scientists are now saying that an experimental Ebola vaccine with 100 percent effectiveness has been developed.
A paper published today in The british medical journal Lancet reports that the vaccine which has been tested in Guinea
The medical authorities carrying out the trial have been using what known as a ing vaccination strategyto test the vaccine efficacy.
but were dismissed ultimately by the medical teams involved for practical reasons. Jeremy Farrar, director of Wellcome Trust, a major supporter of the research, commented on this in an interview with the New york times saying the fact that the trial still achieved positive results in spite of various constraints and limitations,
so you don forget medicine at the store, to connect to your digital wallet and stop you before you overspend.
but with increasing advances in technology, science and medicine, perhaps it isn so unrealistic to think that someday mobile apps like this one will help bridge the gap between patients who lost the capacity to speak,
which develops medical technology for use in patients. Olafsson said his body continues to adapt to his prosthetic limb more each day
Orthopedic surgeon and Ossur's director of research and development, Thorvaldur Ingvarsson implanted the sensors in the two patients involved in the trial himself
"said Varda Shalev, a medical informatics expert and active care primary physician. She is an external consultant to the Tel aviv-based Nuvo Group.
Nuvo Group's advisory board member Professor Simcha Yagel, who also heads the division of obstetrics and gynecology at Hadassah,
Sagitto, 53, a neurosurgery nurse for the past 25 years, was open to the idea of participating in a clinical trial to test out a new technology that gives surgeons the ability to visualize cancer cells in real time
while they operate.""Wow, we have headed into the Superman realm. You have the x-ray vision,
It's better than x-ray vision, according to Dr. Samuel Achilefu, a professor of radiology at Washington University,
surgeons rely on scans taken before the operation to decide how much tissue to remove. He says differentiating between healthy cells
which is why surgeons remove an excess amount of healthy tissue when operating, and even when erring on the side of caution,
"The primary goal of the technology is to make sure that the surgeon does not operate in the blind,
which allows a surgeon wearing specialized glasses to see cancer cells glowing.""What this does is conserve the healthy tissue
Chimaera is designed to make implanting neuromodulators to nerves much easier by integrating surgical sensing and implant delivery functions in one intelligent device.
enabling surgeons to identify critical structures, such as nerves and blood vessels. This combines with the intraoperative data from Chimaera's sensing technology to guide the surgeon to the precise location of a procedure,
helping to ensure the surgical device stays on a predetermined safe pathway. The real-time data generation is designed to be used in conjunction with optical wearable technology, such as Google glass.
This means a surgeon can literally'see'exactly where they are within the body at any point during an operation.
Once the target nerve has been reached the sensors also let the surgeon know, and the implant can then be deployed down the device.
Karger said their aim was to figure out how neuromodulators-measuring less than a centimeter in length-could be implanted as simply and quickly as possible.
and we've combined both implant delivery with surgical tool to provide a completely connected,
unified surgical system that has the potential to take a surgery that maybe only four
and make it accessible to a broad cross-section of general surgeons. By doing that we make it accessible to a much, much broader patient population,
while most of today's surgical tools are largely passive, offering surgeons little feedback, Chimaera opens the door to a new generation of neurostimulation implant procedures.
enable more surgeons to carry out complex operations at lower risk and with better results for patients.
While it may be some time before a device like Chimaera is in surgeons'hands, Karger said it could pave the way for wireless pain management for patients using, for example, their mobile phone:"
"Developers Cambridge Consultants say Chimaera is the equivalent of a'concept car'that demonstrates their vision for the next generation of surgery.
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