inhaled anesthetics like nitrous oxide and halothane have made modern surgery possible. Now, in experiments in mice, researchers at Johns Hopkins and elsewhere have added to evidence that certain so-called"volatile"anesthetics--commonly used during surgeries--may also possess powerful effects on the immune system that can combat viral and bacterial infections in the lung,
including influenza and pneumonia. A report on the experiments is published in the September 1 issue of the journal Anesthesiology.
The Johns Hopkins and University of Buffalo research team built its experiments on previous research showing that children with upper viral respiratory tract infections who were exposed to the anesthetic halothane during minor surgical procedures had significantly less respiratory symptoms
and a shorter duration of symptoms compared with children who did not receive halothane during surgeries.
To examine just how some inhaled anesthetic drugs affect viral and bacterial infections, Krishnan Chakravarthy, M d.,Ph d.,a faculty member at the Johns Hopkins Institute of Nanobiotechnology and a resident physician in the department of anesthesiology and critical
care medicine at Johns hopkins university School of medicine and Paul Knight, M d.,Ph d.,a professor of anesthesiology at the University of Buffalo School of medicine and Biomedical sciences, along with others
Researchers at Rice university, working with colleagues at Baylor College of Medicine and the University of Texas MD Anderson Cancer Center, have made a small molecule that could deliver a one-two punch to proteins that resist chemotherapy
Baylor pediatrician Michele Redell and MD Anderson oncologist David Tweardy appears this week in the journal Angewandte Chemie.
from a medicinal perspective, is that this compound also works in a mouse model, he said. ll the other compounds worked in cells,
and neurodegenerative diseases, validating histone methyltransferases (HMTS) as an important class of drug targets among biomedical researchers.
An estimated 10 to 30 percent of global medicines sold in developing countries like Afghanistan
Medical professionals would then be able to check these small notches with a scanner before they give the medication to a patient.
who is also David G. Nathan Professor of Pediatrics at Harvard Medical school (HMS); Daniel Bauer, also of Dana-Farber/Boston Children and an assistant professor of pediatrics at HMS;
and Feng Zhang of the Broad Institute of MIT and Harvard. The research was spurred by the discovery that naturally occurring beneficial variations in the DNA sequence in this enhancer dial down the molecular switch only in red blood cells.
a pediatric hematologist/oncologist at Dana-Farber/Boston Children. ur goal was to break the enhancer,
a leader of Dana-Farber/Boston Children who serves as chairman of pediatric oncology at the Dana-Farber Cancer Institute
and associate chief of hematology/oncology at Boston Children Hospital. t a very different approach to treating disease. he data provide proof of principle that targeted edits to BCL11A enhancer in blood stem cells could be an attractive approach
a biomedical engineer and faculty member at the Center for Nanomedicine at the Wilmer Eye Institute at Johns Hopkins. Researchers funded by the National Institute of Biomedical Imaging and Bioengineering meanwhile,
#Personalized Heart Models for Surgical Planning Researchers at MIT and Boston Children Hospital have developed a system that can take MRI scans of a patient heart and,
physical model that surgeons can use to plan surgery. The models could provide a more intuitive way for surgeons to assess
and prepare for the anatomical idiosyncrasies of individual patients. ur collaborators are convinced that this will make a difference,
This fall, seven cardiac surgeons at Boston Children Hospital will participate in a study intended to evaluate the modelsusefulness.
Golland and her colleagues will describe their new system at the International Conference on Medical Image Computing and Computer Assisted Intervention in October.
and Andrew Powell, a cardiologist at the hospital, leads the project clinical work. The work was funded by both Boston Children Hospital and by Harvard Catalyst,
But general-purpose image-segmentation algorithms aren reliable enough to produce the very precise models that surgical planning requires.
The problem with that approach is that many of the cardiac patients at Boston Children Hospital require surgery precisely
Inferences from a generic model could obscure the very features that matter most to the surgeon.
Each of seven surgeons will be given data on all 10 patients some probably, more than once. That data will include the raw MRI scans and, on a randomized basis,
the surgeons will draw up surgical plans, which will be compared with documentation of the interventions that were performed on each of the patients.
whether 3-D-printed physical models can actually improve surgical outcomes. bsolutely, a 3-D model would indeed help,
a cardiac surgeon at Boston Children Hospital who is not a co-author on the new paper. e have used this type of model in a few patients,
Doing this really helped with the real surgery in terms of reducing the amount of time spent examining the heart
explained M. Laura Feltri, M d.,senior author on the paper and an HJKRI researcher and professor of biochemistry and neurology in the Jacobs School of medicine and Biomedical sciences at UB. o study myelin,
and other neurodegenerative diseases, because the communication between glial cells and neurons is vital for neuroprotection,
said Poitelon. imilarly, neurodegenerative diseases like Huntington disease or Lou Gehrig's, that were considered uniquely diseases of neurons in the past,
and underscores the need for additional studies, said Rafii. his study will set the stage for the first clinical trial of anti-beta amyloid therapy in the preclinical treatment of Alzheimer disease in adults with Down syndrome.
Studies of AD and other neurodegenerative disorders at UC San diego are part of the clinical and bench strength of the UC System.
biotechnology and medical treatments. The study appears September 21 in Nature Materials. he very simple design rules that we have discovered provide a powerful engineering tool for many biomedical
and biotechnology applications, said Ashutosh Chilkoti, chair of the Department of Biomedical engineering at Duke. e can now,
James Collins, the Termeer Professor of Medical Engineering and Science in MIT Department of Biological engineering and Institute of Medical Engineering and Science (IMES).
an associate professor of neurology and a researcher in the Ahmanson-Lovelace Brain Mapping Center at UCLA. ascular compliance is a useful marker for a number of cardiovascular diseases,
such as hypertension and diabetes, Wang said. rowing evidence suggests intracranial vascular pathology also may be associated with the origin and progression of cerebrovascular disorders and neurodegenerative diseases, such as Alzheimer disease,
an assistant researcher in the UCLA Department of Neurology. number of studies suggest that vascular dysfunctions,
and director of the Eli and Edyth Broad Center of Regeneration Medicine and Stem Cell Research at UCSF. ooking at these early stages in development is the best opportunity to understand our brain evolution.
Such techniques have the potential to enhance research into the origins of neurodevelopmental and neuropsychiatric disorders such as microcephaly, lissencephaly, autism and schizophrenia,
Results were published online Monday by the New england Journal of Medicine and discussed at the European Cancer Congress in Vienna.
The usual treatment is followed surgery by years of a hormone-blocking drug. But many women also are urged to have chemo,
"Dr. Karen Beckerman, a New york city obstetrician diagnosed with breast cancer in 2011, said she was advised to have feared chemo
Mary Lou Smith, a breast cancer survivor and advocate who helped design the trial for ECOG, the Eastern Cooperative Oncology Group,
and circulating tumor cells than using the drugs in a nanogel delivery system without the platelet membrane. e like to do additional preclinical testing on this technique,
She wanted to develop a testbed for her lab basic biomedical research. She was interested, for example,
which plays a role in neurodegenerative diseases, were lower in neurons derived from older patients.
, based on a new study from Northwestern Medicine and the University of Chicago. Children with the disease lose significant muscle strength early in life.
Mcnally is director of the Center for Genetic Medicine at Northwestern University Feinberg School of medicine and the former director of the Institute of Cardiovascular Research at UCHICAGO,
She also is a physician at Northwestern Medicine. The new therapy has been licensed to the Kurt+Peter Foundation,
Mcnally said. his partnership is a perfect example of how precision medicine can help address very rare diseases.
and programs in the UCLA department of neurology. he brain has limited a capacity for recovery after stroke,
. as a possible alternative to surgery for minimally invasive, cosmetic solution, or for SCC where surgery cannot be performed.
Electrospinning uses an electrical charge to create very thin fibers from a liquid. Researchers tested the bandages
and medical doctor Martin D. Burke, built the machine to assemble complex small molecules at the click of a mouse,
They are very important in medicine most medications available now are small molecules as well as in biology as probes to uncover the inner workings of cells and tissues.
flexible and accessible, said Miles Fabian of the National institutes of health s National Institute of General Medical sciences,
The automated synthesis technology has been licensed to REVOLUTION Medicines Inc.,a company that Burke co-founded that focuses on creating new medicines based on small molecules found in nature.
The company initially is focusing on antifungal medications, an area where Burke s research has made already strides.
a team of pioneering surgeons from Stellenbosch University (SU) and Tygerberg Hospital performed the first successful penile transplant in the world.
head of SU's Division of Urology, was performed on 11 december 2014 at Tygerberg Hospital in Bellville, Cape town.
"South africa remains at the forefront of medical progress, "says Prof Jimmy Volmink, Dean of SU's Faculty of medicine and Health Sciences (FMHS)."
"This procedure is another excellent example of how medical research, technical know-how and patient-centred care can be combined in the quest to relieve human suffering.
"Van der Merwe was assisted by Prof Frank Graewe, head of the Division of Plastic Reconstructive Surgery at SU FMHS, Prof Rafique Moosa, head of the FMHS Department of Medicine, transplant
"We are proud of the medical team, who also form part of our own staff compliment at Tygerberg Hospital.
It is good to know that a young man's life has been changed significantly with this very complex surgical feat.
After extensive research Van der Merwe and his surgical team decided to employ some parts of the model
"We used the same type of microscopic surgery to connect small blood vessels and nerves, and the psychological evaluation of patients was also similar.
Marketing and Communication Office Faculty of medicine and Health Sciences Stellenbosch University Prof Andr van der Merwe Head of the Division of Urology arvdm@sun. ac. za Department
of Surgical Sciences Faculty of medicine and Health Sciences Stellenbosch University Hey, check out all the engineering jobs. Post your resume today y
s Alectinib Shrank Tumors in Nearly Half of Patients With Specific Lung cancer Mutation Genentech Investigational Medicine Alectinib Shrank Tumors in Nearly Half of People With Specific Type of Lung cancer--Alectinib showed response rates of up to
Results from both studies will be presented at the 51st Annual Meeting of the American Society of Clinical Oncology ASCO).
and the NP28761 study will be presented by Dr. Leena Gandhi, assistant professor of medicine, Dana-Farber Cancer Institute, Boston (Abstract#8019, Monday, June 1, 8: 00-11:30 A m. CDT).
and review of medicines intended to treat serious diseases and to help ensure patients have access to them through FDA approval as soon as possible.
About Alectinib Alectinib (RG7853/AF-802/RO5424802/CH5424802) is an investigational oral medicine created at Chugai Kamakura Research Laboratories
medicines and tests that can help people with this deadly disease. Our goal is to provide an effective treatment option for every person diagnosed with lung cancer.
We currently have approved two medicines to treat certain kinds of lung cancer and more than 10 medicines being developed to target the most common genetic drivers of lung cancer
or to boost the immune system to combat the disease. About Genentech Founded more than 35 years ago
develops, manufactures and commercializes medicines to treat patients with serious or life-threatening medical conditions.
This means they are not eligible for surgery to remove the tumour-currently the only potentially curative treatment.
It is believed to be the first time voluntary leg movements have ever been relearned in completely paralyzed patients without surgery.
said V. Reggie Edgerton, senior author of the research and a UCLA distinguished professor of integrative biology and physiology, neurobiology and neurosurgery.
The research was funded by the National institutes of health National Institute of Biomedical Imaging and Bioengineering (grants U01eb15521 and R01eb007615), the Christopher and Dana Reeve Foundation,
director of the National Institute of Biomedical Imaging and Bioengineering. he potential to offer a life-changing therapy to patients without requiring surgery would be a major advance;
Edgerton estimates that cost to patients of the new approach could be one-tenth the cost of treatment using the surgical epidural stimulator
because no surgery is required, it would likely be more easily available to more patients. The study co-authors were conceived Gerasimenko,
as well as Lu, associate professor of neurosurgery in UCLA David Geffen School of medicine, and researchers Morteza Modaber, Roland Roy and Dimitry Sayenko, research technician Sharon Zdunowski, research scientist Parag Gad, laboratory coordinator Erika Morikawa and research
and Adam Ferguson, assistant professor of neurological surgery at UC San francisco. Edgerton and his research team also plan to study people who have severe,
The results of the study were published in the Journal of Medicinal Chemistry. Surgery, associated with cardiovascular diseases, such as ischemia,
often require the implantation of vascular grafts-artificial blood vessels, aimed at restoring the blood flow in a problematic part of the circulatory system.
which results in compulsory and lifelong intake of anticoagulants among patients and sometimes may even require an additional surgical intervention.
they actively release medicine into the blood. The lifetime of such grafts is determined often by the amount of drug stored within the graft,
The same approach may be used for kidney or liver surgery, but these are plans for the future,
a radiologist and director of the Center for Systems Biology lab at Massachusetts General Hospital who is familiar with the research. hatever you can do right then and there without any complicated testing,
The technique could improve access to medicines in impoverished nations. For thousands of years, people have used yeast to ferment wine,
Now Stanford researchers have engineered genetically yeast to make painkilling medicines, a breakthrough that heralds a faster and potentially less expensive way to produce many different types of plant-based medicines.
Writing Aug 13 in Science, the engineers describe how they reprogrammed the genetic machinery of baker yeast
It can take more than a year to produce a batch of medicine, starting from the farms in Australia,
and refined into medicines. hen we started work a decade ago, many experts thought it would be impossible to engineer yeast to replace the entire farm-to-factory process,
plant-based medicines. his is only the beginning, Smolke said. he techniques we developed and demonstrate for opioid pain relievers can be adapted to produce many plant-derived compounds to fight cancers, infectious diseases and chronic conditions such as high blood pressure and arthritis.
From plant to test tubes Many medicines are derived from plants which our ancestors chewed or brewed into teas,
to reprogram the cells into custom chemical assembly lines to produce medicinal compounds. An important predecessor to the Stanford work has been the use of genetically engineered yeast to produce the antimalarial drug artemisinin.
the team had to fill in a missing link in the basic science of plant-based medicines.
Many plants, including opium poppies, produce (S)- reticuline, a molecule that is a precursor to active ingredients with medicinal properties.
Smolke said. e need options to help ensure that the bio-based production of medicinal compounds is developed in the most responsible way.
where opioid medicines are already widely available, the focus is on potential misuse. But the World health organization estimates that 5. 5 billion people have little
and the techniques we developed show that it is possible to make important medicines from scratch using only yeast,
and fairly provide medicines to all who need. Stanford has patents on the technology, and Smolke and researchers on her team have formed a company.
#Minimally Invasive Robotic Surgical Tool Feels For Tumors, Study Tumors often look identical to healthy nearby tissue,
Surgeons often use their fingers to feel the size and shape of what to be resected,
A team of researchers from Canadian Surgical Technologies & Advanced Robotics (CSTAR) and Western University developed a robotic arm compatible with the Da vinci robotic surgical system that can sense how hard
The device was an entry into the Surgical Robot Challenge 2015 recently hosted by Imperial College London.
"said first author Mackenzie Lind, a doctoral candidate at the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University in Richmond."
According to the American Academy of Sleep Medicine, transient insomnia symptoms occur in 30 to 35 percent of the population.
analyzed data from the Virginia Adult Twin Studies of Psychiatric and Substance Use Disorders, a large twin data set of approximately 7, 500 participants collected by Dr. Kenneth S
In experiments, they trained a machine-learning system on MRI data from patients with neurodegenerative diseases
and by Mert Sabuncu, an assistant professor of radiology at Massachusetts General Hospital, who was a postdoc in Golland group.
The researchers are presenting the paper at the International Conference on Medical Image Computing and Computer Assisted Intervention this week.
Common denominator In their experiments, the researchers used data from the Alzheimer Disease Neuroimaging Initiative, a longitudinal study on neurodegenerative disease that includes MRI scans of the same subjects taken months and years apart.
The brains of healthy subjects and subjects in the early stages of neurodegenerative disease change little over time,
a professor of radiology at Harvard Medical school and director of the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital. ut the fact that it did did as well as it is encouraging. here are lots of ways these tools could be beneficial to the research community,
Working with gut stem cells from humans and mice, scientists from the Johns Hopkins Children's Center and the University of Pittsburgh have grown successfully healthy intestine atop a 3-D scaffold made of a substance used in surgical sutures.
The tube-shaped scaffold, designed several years ago in collaboration with Cornell University researchers and composed of biodegradable material similar to that used in surgical sutures
"says principal investigator David Hackam, M d.,Ph d.,the Johns Hopkins Children's Center's surgeon-in-chief,
researchers took stem cells from the colons of babies undergoing intestinal surgeries and from mice,
"says study author Stephen Badylak, D. V. M.,Ph d.,M d.,professor of surgery and deputy director of the Mcgowan Institute for Regenerative medicine at the University of Pittsburgh."
The work was funded by a Hartwell Biomedical Collaborative Research Award with additional support from National institutes of health grants R01gm078238 and RO1DK08752 2
."Although rehabilitation medicine has resulted in reductions in mortality, the current outcome for patients is permanent paralysis, with an overall cost to the community of $2 billion a year."
Her research today involves translating molecular imaging research to point-of-care diagnostics describes the fluorescence microscope system this week in a paper published in Biomedical Optics Express, from The Optical Society.
The tomatoes themselves could potentially become the source of increased nutritional or medicinal benefit. Professor Cathie Martin said:"
Our work will be of interest to different research areas including fundamental research on plants, plant/microbe engineering, medicinal plant natural products,
"Medicinal plants with high value are often difficult to grow and manage, and need very long cultivation times to produce the desired compounds.
Our research provides a fantastic platform to quickly produce these valuable medicinal compounds in tomatoes.
which are the major groups of medicinal compounds from plants
#3-D Pancreatic cancer Organoid May Help Predict Clinical Responses, Nature Medicine Publishes 3-D pancreatic cancer organoid may help predict clinical responses,
personalize treatments. Clonally derived organoids could be used to ID patient-specific sensitivities to novel therapeutics.
The development of a new method to grow three-dimensional organoid cultures of pancreatic tumors directly from patients'surgical tissue offers a promising opportunity for testing targeted therapies
The findings are reported currently in the Advance Online issue of the journal Nature Medicine.""These 3d organoids are, essentially,
"We have developed now a new methodology to grow human pancreatic tumor cells from surgical tissues
And from a clinical point of view, this approach could help assist patients and their oncologists in making treatment decisions.""
Armin Alaedini, assistant professor of medical sciences at Columbia University and a researcher at the New york-based school's Celiac disease Center, said the project may end up with a less toxic wheat product that isn't completely safe for all celiac disease patients."
The medical advisory board for the Celiac disease Foundation, a nonprofit based in Woodland Hills, California, could not reach a consensus on the viability of Miller's research.
while antibiotics used in medicine by humans have developed resistance in just 70 years. The team has registered copsin for patent approval l
brain-controlled walking after a complete spinal cord injury,"said biomedical engineer Zoran Nenadic, who led the research. 3. 6 metres The steps taken a year ago by the experiment's subject,
so that it takes away that need for your medical knowledge, "he said. The 24/7 device monitors a user's blood pressure, heart rate, blood oxygen levels
something that the doctors and surgeons involved felt was handled best by this new technology. Traditionally
This surgery was the first of its kind, but thanks to its success it raises the bar of possibility in the ongoing relationship between 3d printing
Professor John Aplin, a specialist in reproductive medicine at Manchester University who also took part in the study,
And the results may be useful in creating better memory storage systems for computers or medical sensors.
of the Department of Psychiatry, said:''We need a way of treating the cognitive symptoms of schizophrenia, such as problems with episodic memory,
'Professor Peter Jones, also from the Department of Psychiatry, added:''These are promising results and suggest that there may be the potential to use game apps to not only improve a patient's episodic memory,
when he was struggling to sleep during his exams at a medical university. He said:'
THE BENEFITS OF THC There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
There's already evidence to suggest certain compounds in marijuana might be helpful for certain medical conditions.
is precisely the type of knowledge medicine needs if we are to improve IVF methods.
Major general Steve Jones, commander of the Army Medical Department Centre and chief of the US ARMY Medical Corps
Speaking at a medical conference sponsored by the Association of the US ARMY near the Pentagon in Arlington County, Virginia,
Professor Rodney Phillips, a former Oxford don and now dean of medicine at the University of New south wales, played an instrumental role.
they created an easy way to tweak the genetic information in a cell nucleus. This has implications for medicine and agriculture.
to this year meeting of the American Society of Tropical Medicine and Hygiene, in Philadelphia, has changed that.
The discoverers of ivermectin predecessor, avermectin, were among the winners of this year Nobel prize for medicine.
#Why This Hearing Device Is Making Noise With Investors Ear surgeon Rodney Perkins has an impressive track record building companies around
though you just walked out of a teeth-cleaning session at the dentist's, Misoka designers said in a recent interview.
In the areas of surgery and molecule detection, for example, they offer significant advantages compared to traditional, shorter-wavelength lasers.
Bloodless surgery and long-range molecule détection Two-micron spectral domain has potential applications in medicine, environmental sciences and industry.
In the realm of high precision surgery they can be used to target water molecules during an operation
Biomedical scientists at the Sanford-Burnham-Prebys Medical Discovery Institute (SBP) and UC Santa barbara (UCSB) have discovered now a mechanism by
The tomatoes themselves could potentially become the source of increased nutritional or medicinal benefit. Professor Cathie Martin said:"
Our work will be of interest to different research areas including fundamental research on plants, plant/microbe engineering, medicinal plant natural products,
"Medicinal plants with high value are often difficult to grow and manage, and need very long cultivation times to produce the desired compounds.
Our research provides a fantastic platform to quickly produce these valuable medicinal compounds in tomatoes.
which are the major groups of medicinal compounds from plants
#Wood instead of petroleum: Producing chemical substances solely from renewable resources Petroleum might well be replaced by wood soon
The German research team led by Professor Till Opatz at JGU's Institute of Organic chemistry participates in the interdisciplinary research consortium Chemical Biomedicine (Chembiomed) funded by the Carl Zeiss Foundation
and young adults with rare blood disorders Hematology researchers have safely and effectively treated children and young adults for autoimmune blood disorders in a multicenter clinical trial.
"said study leader David T. Teachey, M d.,a physician-researcher in hematology and oncology at The Children's Hospital of Philadelphia (CHOP)."
"Most patients never receive an evaluation by a neurologist skilled in the diagnosis of Lewy body dementia,
and a professor of clinical biomedical science in FAU's Charles E. Schmidt College of Medicine and a professor in FAU's Christine E. Lynn College of Nursing."
and differentiate LBD from healthy aging and other neurodegenerative diseases. Galvin has led efforts to develop a number of dementia screening tools,
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