research leader at MIMS, Molecular Infection Medicine Sweden at Umeå University. Our innate immune system is activated
These discoveries will form the basis for precision medicine of CLL and other tumor types
This study utilized 36 well-characterized melanoma cell lines assembled by the MGH Center for Molecular Therapeutics to test all possible combinations of more than 100 oncology drugs,
who is a research fellow in Dermatology at Harvard Medical school.""What is really exciting is that these drugs are already in the clinic;
and do not in others is one of the top goals of oncology, and also one of the oldest. 126 years ago, The british physician, Stephen Paget, formulated his'seed and soil theory,
'In recent years, Héctor Peinado, Head of the Microenvironment and Metastasis Group at the Spanish National Cancer Research Centre (CNIO), David Lyden from Weill Cornell Medical College,
"The study was performed using human and mouse tumour cell lines, preclinical mouse models, as well as plasma from cancer patients.
which involves obtaining multiple cellular and preclinical models, as well as human samples. The search for these models has been carried out over the last three years with the participation of many teams,
Ph d.,study author from the Department of Biomedicine, at the University of Bergen in Bergen, Norway."
a Phd student in the Department of Biomedical Physiology and Kinesiology and lead author of the paper.
Over three years, researchers at the University of Cambridge took surgical tumour samples (biopsies) and blood samples from a patient with breast cancer that had already spread to other parts of her body.
"For now, surgical biopsies still play an important role in diagnosing and monitoring cancers. But this work gives us a window into the future,
The case is outlined in the November issue of Pediatrics.""Based on the images we had, it was unclear
"says senior author Glenn Green, M d.,associate professor of pediatric otolaryngology at U-M's C. S. Mott Children's Hospital."
so that a surgeon can establish an airway to allow the baby to breathe. Instead, Conan was born via a scheduled C-section."
I didn't need the more complicated and risky surgery and could be awake for the birth of my first baby.
professor of biomedical engineering and mechanical engineering and associate professor of surgery at U-M. The models were printed by Ann arbor-based Thingsmiths.
of the U-M division of Otolaryngology-Head and Neck Surgery. 3-D printing has had many medical applications.
Green and Hollister are leading efforts to design customized medical implants for those and other patients s
Scientists, therefore, hope to deploy them as agents in the treatment of neurodegenerative diseases. Using the example of a small heat shock protein,
This also includes the potentially disease-causing proteins that collect in the cells of patients with neurodegenerative disorders--for example
it would improve their ability to attach to the disease-causing fibrils--a first step in the development of new agents against Alzheimer's and other neurodegenerative diseases.
Efstathios Karathanasis, a biomedical engineer at Case School of engineering, has developed chainlike nanoparticles that can carry drugs across the blood-brain barrier that keeps standard medicines from reaching their target--a highly aggressive brain cancer called
The nanochains will tote bombs of chemotherapy medicine and glioblastoma stem cell inhibitors identified by Jeremy Rich,
And"surgeons can't go in and cut liberally,"Karathanasis said.""Brain tumor cells are often invasive and spread throughout the normal brain,
The Karathanasis and Rich labs will work with Mark Griswold, professor of radiology at Case Western Reserve School of medicine,
Ketan Ghaghada, assistant professor of radiology at Baylor College of Medicine, will guide and oversee the steps taken to translate the research toward clinical trials.
Her research today involves translating molecular imaging research to point-of-care diagnostics--describes the fluorescence microscope system this week in a paper published in Biomedical Optics Express, from The Optical Society.
Biomedical scientists at UC Santa barbara and the Sanford-Burnham-Prebys (SBP) Medical Discovery Institute have discovered now a mechanism by
The multi-institutional group includes researchers from Baylor College of Medicine Rice university, Stanford university and the Broad Institute.
Rao likened the result to a new form of genome surgery: a procedure that can modify how a genome is folded by design and with extraordinary precision."
and animals (it is responsible for neurodegenerative diseases such as spongiform encephalopathies). According to a new SISSA study, the mechanism underlying this change is a metal, copper,
Steel surgical tools can still carry microorganisms that cause deadly infections. Now researchers at the Harvard John A. Paulson School of engineering and Applied sciences (SEAS) have demonstrated a way to make steel stronger, safer and more durable.
and avenues for commercialization, including non-fouling medical tools and devices, such as implants and scalpels, nozzles for 3d printing and, potentially, larger-scale applications for buildings and marine vessels.
Medical steel devices are one of the material's most promising applications, said Philseok Kim,
and cofounder and vice president of technology AT SEAS spin-off SLIPS Technologies Inc."Because we show that this material successfully repels bacteria and blood, small medical implants,
Lungs and pancreas Having proved the preclinical effectiveness of the new drug in treating cancer stem cells in breast, colon,
."Although rehabilitation medicine has resulted in reductions in mortality, the current outcome for patients is permanent paralysis, with an overall cost to the community of $2 billion a year."
highly sensitive magnetometers intended for life science and medical applications
#Scientists gain insight into origin of tungsten-ditelluride's magnetoresistance Scientists recently discovered that tungsten ditelluride (WTE2) is electronically three-dimensional with a low anisotropy.
"explained corresponding author James Hamilton, Phd, professor of physiology and biophysics and research professor of medicine at BUSM."
The new findings, described in today's issue of the journal Science Translational Medicine, show that this molecule,
"said the study's corresponding author Richard L. Sidman, MD, an investigator in the Department of Neurology at BIDMC and Bullard Professor of Neuropathology (Neuroscience), Emeritus, at Harvard Medical school.
according to a study published online today in Blood, the Journal of the American Society of Hematology (ASH).
when surgery is most effective. We also need to make sure that men with indolent disease do not receive unnecessary treatment
New research is now underway in the Mongan's laboratory at Nottingham to test the effect of various pharmacological treatments in preclinical prostate cancer studies
Several 2013 studies from Hyman's group and others showed the movement of a mutant form of tau between brain structures and resultant neurodegeneration in a mouse model.
"says Hyman, the John Penny Professor of Neurology at Harvard Medical school.""Since that spread likely underlies clinical progression of symptoms,
For the study, the team activated AMPK signaling with drugs that have been used medically to protect heart tissue during surgery
However, fields such as medicine or controlled catalysis call for more precise distribution in order to achieve the greatest possible efficiency of the active agent.
Their new approach created the first-ever flexible Fresnel zone plate microlenses with a wide field of view--a development that could allow everything from surgical scopes to security cameras to capture a broader perspective at a fraction of the size required by conventional lenses.
Their new approach created the first-ever flexible Fresnel zone plate microlenses with a wide field of view--a development that could allow everything from surgical scopes to security cameras to capture a broader perspective at a fraction of the size required by conventional lenses.
"We have discovered that it is the plant equivalent of the nude mouse used in medical research.""
Their findings, published in Neurosurgery, lend hope to patients around the world with neurological conditions that are difficult to treat due to a barrier mechanism that prevents approximately 98 percent of drugs from reaching the brain and central nervous system."
"We are developing a platform that may eventually be used to deliver a variety of drugs to the brain,
"Although we are currently looking at neurodegenerative disease, there is potential for the technology to be expanded to psychiatric diseases, chronic pain,
seizure disorders and many other conditions affecting the brain and nervous system down the road.""Using nasal mucosal grafting,
Nasal mucosal grafting is a technique regularly used in the ENT field to reconstruct the barrier around the brain after surgery to the skull base.
ENT surgeons commonly use endoscopic approaches to remove brain tumors through the nose by making a window through the blood-brain barrier to access the brain.
surgeons may create a"screen door"to allow for drug delivery to the brain and central nervous system. The technique has the potential to benefit a large population of patients with neurodegenerative disorders,
where there remains a specific unmet need for blood-brain penetrating therapeutic delivery strategies.""We see this expanding beyond Parkinson's disease,
Eye and Ear is a Harvard Medical school teaching hospital and trains future medical leaders in ophthalmology and otolaryngology, through residency as well as clinical and research fellowships.
Eye and Ear Departments of Otolaryngology and Ophthalmology as top in the nation n
#Breakthrough to the development of energy saving devices for the next generation Wide-gap semiconductors such as gallium nitride (Gan) are used widely for optical devices such as blue LED
"We should expect to see 3-D bioprinting continue to grow as an important tool for a large number of medical applications."
Otherwise, hey, better medical technology thanks to 3d printing is good for everyone o
#This new high-power diamond laser can cut steel Although lasers based on diamond have been around around for several years,
and biomedical engineers are even looking into using them as a bio-safe internal optical network.
the device could have applications in voice-command electronics, medical sensing devices that use waves, like ultrasound,
practice medicine and improve the quality of life for patients. These other services create a better experience for both patient and provider.
including medical appointments. These workers will bring the senior citizen an ipad, and sit with them
The app will remind patients to take their medicines (the fictional anecdote used by IBM executives to explain that used a woman who kept forgetting her blood pressure medicine
the patient high blood pressure would mean that getting her to take her medicine more often would improve her life.
or the last couple miles in helping improve medical adherence and patient outcomes. Especially as more doctor visits and care end up shifted to telehealth,
But a big opportunity for rapid progress has emerged as online medical education becomes increasingly common.
Medical education in emerging markets typically suffers from two problems. First, medical universities and residency programs rarely have qualified enough instructors,
and sometimes lack access to modern curricula and equipment. Second, weak or nonexistent continuing medical education (CME) programs prevent health workers from later keeping their skills sharp.
Medical education typically begins with university coursework, and many medical schools now use e-learning tools like webcasts
In radiology, for instance, a growing number of hospitals around the world now use software by Lifetrack Medical Systems,
The software enables radiology residents to receive virtual training from qualified practitioners anywhere in the world boon for places like Indonesia and Myanmar with acute radiologist shortages.
Even surgery can now be taught remotely with technologies that combine virtual reality with AI techniques to train both real time decision-making and psychomotor skills.
says theye actively being used for surgery students in Thailand. He believes they will be particularly valuable in emerging markets facing shortages of expert surgeons.
Irrespective of specialty, medical education must be a lifelong pursuit for all healthcare professionals, and in developed countries, regulators and professional associations typically require health workers to periodically participate in ongoing programs to keep their skills sharp.
Many emerging countries lack such requirements, but online platforms are starting to fill this critical gap.
FHI360 is another NGO using innovative online platforms to provide continuing medical education in emerging markets.
Unlike in the Premera breach, medical data and banking information were believed not to have been exposed in the Anthem breach.
or pharmacies seeking prescriptions. he law says we have a corresponding responsibility to make sure that medications are used for legitimate medical purposes,
The material potentially could extend the life of medical implants, fiber-optic cables, and other hard-to-repair objects,
and gynecologists use ultrasound images to study fetuses in the womb. Material testing procedures that regularly check for fissures in rail tracks or aircraft support structures also rely on ultrasound.
He is aiming to improve the acoustic imaging method for potential use in biological research or medicine
#Vaccine might replace surgery for cervical cancer A genetically engineered cervical cancer vaccine performed well in a clinical trial,
offering hope that many women can one day avoid surgery that short-circuits the disease but threatens their ability to have a baby.
says Cornelia Trimble, professor of gynecology and obstetrics, oncology, and pathology at Johns hopkins university School of medicine. vaccine able to cure precancerous lesions could eventually be one way women can avoid surgery that is invasive
and can also harm their fertility. The cervix is the lower part of a woman uterus.
they are removed today usually by surgery, freezing, or laser treatment. The procedures remove the precancerous areas in about 80 percent of women.
and Women Hospital in Boston and is now an assistant professor of medicine in the nephrology division at the University of Washington. nswering this question was important for understanding the potential of mini-kidneys for clinical kidney regeneration and drug discovery.
and the Biomedical Research Centre at the University of British columbia funded the work. Bonventre holds patents on kidney injury molecule-1
and a 3d printer, bioengineers and surgeons have created an implant with an intricate network of blood vessels.
or weeks to grow in the lab prior to surgery. A research team led by Jordan Miller, assistant professor of bioengineering at Rice university,
and Pavan Atluri, assistant professor of surgery at the University of Pennsylvania, conducted the study. Published in the journal Tissue Engineering Part C:
In this study, we are taking the first step toward applying an analogy from transplant surgery to 3d-printed constructs we make in the lab. Miller
and his team thought long-term about what the needs would be for transplantation of large tissues made in the laboratory. hat a surgeon needs
in order to do transplant surgery isn just a mass of cells; the surgeon needs a vessel inlet
and an outlet that can be connected directly to arteries and veins, he says. SUGAR AGESBIOENGINEERING graduate student Samantha Paulsen and research technician Anderson Ta worked together to develop a proof-of-concept construct small silicone gel about the size of a small candy gummy bearsing 3d printing.
but they have some of the key features relevant for a transplant surgeon, Miller says. e created a construct that has one inlet and one outlet,
Collaborating surgeons at Penn in Atluri group connected the inlet and outlet of the engineered gel to a major artery in a small animal model.
and unobstructed for up to three hours. his study provides a first step toward developing a transplant model for tissue engineering where the surgeon can directly connect arteries to an engineered tissue,
and mental states, has been linked to numerous neurological and mental illnesses, including depression. But because there has been no way to obtain live human serotonin neurons to study these diseases,
The work, published in Molecular Psychiatry, builds on previous studies showing that human fibroblasts can be converted to neurons,
The findings appear online in the Journal of the American Academy of Dermatology. WHY ISN THIS TREATMENT CATCHING ON?
says study leader Emanual Maverakis, an associate professor of dermatology at the University of California, Davis. ur results demonstrate that intralesional therapy with a protein that causes immune cells to divide,
Historically, treatment for these metastatic lesions has been surgical excision with or without radiation therapy, but disease recurrences can still be very high.
The patients had been seen by the dermatology service between 2006 and 2015; most were had elderly and other illnesses.
Ten of the 11 patients had experienced recurrences of the disease after surgery, and several had failed nonsurgical treatments, as well.
Funding for the study came from Burroughs Wellcome Fund, Howard Hughes Medical Institute, and the National institutes of health N
and potentially cheaper way to make other types of plant-based medicine. Hydrocodone and its chemical relatives such as morphine and oxycodone are opioids,
It can take more than a year to produce a batch of medicine, starting from the farms in Australia, Europe,
and refined into medicines. hen we started work a decade ago, many experts thought it would be impossible to engineer yeast to replace the entire farm-to-factory process,
400 gallons of bioengineered yeast to produce a single dose of pain reliefhe experiment proves that bioengineered yeast can make complex plant-based medicines. his is only the beginning,
infectious diseases and chronic conditions such as high blood pressure and arthritis. any medicines are derived from plants, which our ancestors chewed
to reprogram the cells into custom chemical assembly lines to produce medicinal compounds. An important predecessor to the new work has been the use of genetically engineered yeast to produce the antimalarial drug artemisinin.
the Stanford team had to fill in a missing link in the basic science of plant-based medicines.
Many plants, including opium poppies, produce (S)- reticuline, a molecule that is a precursor to active ingredients with medicinal properties.
Smolke says. e need options to help ensure that the bio-based production of medicinal compounds is developed in the most responsible way. molke says that in the United states,
where opioid medicines are already widely available, the focus is on potential misuse. But the World health organization estimates that 5. 5 billion people have little
and the techniques we developed show that it is possible to make important medicines from scratch using only yeast,
and fairly provide medicines to all who need. tanford has patents on the technology and Smolke and researchers on her team have formed a company o
This means they are not eligible for surgery to remove the tumorurrently the only potentially curative treatment.
"explained lead author Maryam Oskoui, M d.,pediatric neurologist at The Montreal Children's Hospital (MCH) of the MUHC and co-director of the Canadian Cerebral palsy Registry."
"stated co-author Michael Shevell, M d. co-director of the Canadian Cerebral palsy Registry and chair of the Department of Pediatrics at the MCH-MUHC."
"explained senior author M. Laura Feltri, M d.,professor of biochemistry and neurology in the Jacobs School of medicine and Biomedical sciences at UB."
"Similarly, neurodegenerative diseases like Huntington's disease or Lou Gehrig's, that were considered unique diseases of neurons in the past,
senior author James Collins, Ph d.,professor of medical engineering and science in MIT's Department of Biological engineering and Institute of Medical Engineering and Science (IMES)."
This new design could aid efforts in building point-of-care devices for quick medical evaluations.
which would enhance the effectiveness of medical interventions. The findings from this study were published recently in the Journal of the American Chemical Society through an article entitled highly selective electrochemical DNA-based sensor that employs steric hindrance effects to detect proteins directly in whole blood.
but we just didn't have the technology to find it,"noted project leader Mads Daugaard, Ph d.,assistant professor of urologic science at UBC and a senior research scientist at the Vancouver Prostate Centre, part of the Vancouver Coastal
"This is an extraordinary finding that paves the way for targeting sugar molecules in pediatric and adulthood human cancer,
"said co-senior investigator Poul Sorensen, M d.,Ph d.,UBC professor of pathology and laboratory medicine.
"There is some irony that a disease as destructive as malaria might be exploited to treat another dreaded disease,"stated lead author Ali Salanti, Ph d.,professor of immunology and microbiology in the Centre for Medical Parasitology, at the University
robotics, gesture recognition, biomedical imaging, personal electronics, and more. A paper describing the research was published in the journal Optics Express E
and send it off to a medical professional for analysis, wherever in the world they may be.
With the speed improvements in mind, the method is now approaching a state viable for widespread medical use.
The new imaging system could have huge implications in medicine because it drastically reduces the time required to analyze
Watson can handle extremely large amounts of data as an aid to decision making in medicine, customer service, finance,
Getting the medicine to the clot takes some guesswork and there's no guarantee it will arrive in the right dosage,
you could build the tissue right at the surgery time to be whatever size that you require,
Surgeons could then graft the scaffold onto the patient's heart, and after a few months the patient would be left with a repaired heart (and no scaffold,
The results of this research were presented recently at the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society in Milan
and record subsequent images which a medical professional can then download and add to the complete diagnostic data Set in testing thus far,
the researchers believe that the feasibility of the propulsion model will move their creation toward the next set of experiments and onward to eventual deployment in working medical applications.
#3d-printed guide aids in complex nerve regeneration Complex nerve injuries are a challenging problem for the medical fraternity,
#Biodegradable implant could simplify bone replacement surgery Combining cornstarch with volcanic ash clay to create a plastic for bone grafts could make the surgical process of bone replacement much simpler in the future.
The preclinical findings come from researchers at Beaumont Hospital-Royal oak and will be published in the journal Nanomedicine.
including following tumor removal, spinal fusion surgery or fractures. Normally, bone grafts involve using bone from another part of the patient's body,
Kevin Baker, Ph d.,director of the Beaumont Orthopaedic Research Laboratories, worked on the study with Rangaramanujam Kannan, Ph d.,of Johns Hopkins (formerly with Wayne State university.
"In addition, from the surgeon perspective, not having to worry about a large piece of metal or hard plastic in the area may make future procedures easier."
In addition to inhibiting bacterial damage to teeth implants, the researchers believe the material may also be suitable for orthopaedic and non-medical applications
Already in use in some German pediatric clinics, the comb has conductive teeth that serve as electrodes.
including medicine, to be able to have glues that would work in an aqueous environment,
it may be possible to make target human neurons temporarily susceptible to the ultrasound signal in a clinical setting for certain neurological treatments."
The process may be suited aptly for this field of medicine because nerves do not regenerate much after injury
This makes the announcement in Nature Medicine that salsalate inhibits and reverses the acetylation of tau particularly significant.
as long as they share a few genetic characteristics with known viruses. According to Kristine Wylie, assistant professor of pediatrics at the university Mcdonnell Genome Institute,
if new organs could be printed out and used in surgical operations to save people lives?(Video) As it turns out,
essentially filling in the printed caffoldingwith its biological oncrete This research has obvious implications for medical science.
As a backup, medical tape can ensure the device stays put. undamentally, what we were trying to do was remove the relative motion between the body and detector system,
But once that happens, such devices could help revolutionize medicine by providing an unprecedented amount of data for understanding health conditions such as diabetes, the hardening of arteries,
Such flexible sensors could also be placed on internal organs, surgical tools, or implantable devices. For now, Webb and his colleagues continue to refine the heat-mapping blood flow device with the goal of making it smaller.
and replicate organs for preclinical studies, but this is the first FDA approval of a drug product.
and other high-dose medicines that rapidly disintegrate with a small amount of liquid, and says it has exclusive rights to pharmaceutical applications of the technology.
and senior author of a new study in Science Translational Medicine. ou need to get macrophages under control quickly in sepsis.
what it takes to cope with stress in much the same way that a sports star medical information might be handed over
#Biomedical 3d printing Company Signs Agreement with Xilloc for Licensing, Sale of 3d-Printed Bones in Europe (3ders. org) NEXT 21 K. K,
. an innovative Japanese biomedical 3d printing company, has created a 3d bone printer capable of producing artificial bone structures for humans.
Custom-Fit Knee Replacements Dr. Ralph Liebelt is one of the few surgeons in the country to use 3d-printed, custom-fit knee replacements.
Liebelt, with Triangle Orthopaedic Associates, said about 20 percent of patients with traditional methods are satisfied not with the results of knee surgery.
He explained that doctors performing knee replacement surgery typically insert a standard off-the-shelf implant then decide how much bone to remove
or by specialists in specific medical fields. Rodelis Therapeutics acquired the rights to TB drug cycloserine in August,
Professor of Hematology/Oncology at the University of Chicago, there are just not enough players in the generic specialty drug market that have the capability to manufacture these drugs.
Conti and her team studied the launch price of new oncology drugs from 1996 to 2012.
denying seniors access to many medicines, said Thrope. nd, artificially low prices could deprive drug companies of future funds to invest in the risky, expensive research that leads to better treatments and cures.
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