Gene expression

Epigenetics (76)
Gene expression (114)
Gene therapy (152)
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Genetics (455)
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Synopsis: Biotech: Genetics: Gene expression:

The researchers speculate that byproducts from other bacteria infections in other diseases might change gene expression using similar mechanisms.

Genome-wide patterns of gene expression showed that Myc heterozygotes had significant differences in pathways related to metabolism and the immune system.

Also similar were protein markers. aive cells have differences in gene expression, but also in their epigenome,

helping scientists to better understand how gene expression is controlled. Indeed, the ultimate goal, explains project coordinator Dr Lars Jansen,

This means that heritable changes in gene expression are caused by mechanisms other than changes in the underlying DNA sequence.

can we even get gene expression in paper?####says Pardee. Using a standard laser printer stocked with special wax-based inks he printed patterns of small dots onto uncoated filter paper.

When the team measured gene expression first in the stem cells, and then reevaluated the cells once they had become neurons,

Transcription factors known as genetic switches drive gene expression in plants based on external stresses such as light rain soil quality

and thereby influence gene expression the more we may be breed able to or develop with biotechnological methods crops that are more resistant to those stresses.

It is a critical component in the pathway of gene expression which controls an organism s function.

or a few RNAS you can t get a pattern. ow that we have genome-wide information for a particular organism we can start to abstract patterns of how RNA structure influences gene expression and ultimately plant function.

Are there universal rules that will be true for all organisms for how RNA structure influences gene expression?

What they knew from a prior study is that the gene expression in pollen tubes that had grown through a pistil was much different than that of pollen tubes grown in the lab. Leydon s first step

therefore was to see which regulators of gene expression or transcription factors were at work in pistil-grown pollen tubes but not in the lab-grown ones.

Examples from the prenatal gene expression (left) and reference (right) atlases. Image: Allen Institute for Brain science) The map of a healthy developing brain also provides clues to the origin of developmental disorders such as autism the researchers said.

researchers have been trying to understand just how similar they are to ES cells. ips cells begin with different patterns of gene expression,

naturally occurring circular RNA molecules that influence gene expression. At least some of the loops, described in two papers published this week by Nature1,

They found that it contains about 70 binding sites for a microrna called mir-7. Micrornas are short fragments of RNA that can block gene expression by binding to

because you can design them to treat any type of disease by modifying gene expression very specifically says James Dahlman a graduate student in Anderson s

With the best-performing particles, the researchers reduced gene expression by more than 50 percent, for a dose of only 0. 20 milligrams per kilogram of solution about one-hundredth of the amount required with existing endothelial

Arjun Raj and his collaborators at the University of Pennsylvania invented a technique to track that gene expression and its effects.

The technique will also allow researchers to examine gene expression in individual cells without removing them from tissue,

"but are, in fact, important in regulating gene expression.""Our results provide novel insights into the regulation of early embryonic development in human,"added Outi Hovatta, professor at Karolinska Institutet's department of clinical science, intervention and technology.

and gene expression differences induced by progerin. However, telomerase could not rescue the loss of heterochromatin.

These latter Cas9 variants are fused commonly with proteins that regulate gene expression. Now, using a new approach developed by researchers led by George Church, Ph d.,of Harvard and Ron Weiss, Ph d.,of the Massachusetts institute of technology,

we can now for the first time toggle a single protein to gain direct control over both, gene sequences and gene expression,

'but are in fact important in regulating gene expression. In the current study, the researchers show that the newly identified genes can interact with the'junk DNA,

These epigenetic modifications regulate gene expression, impacting normal growth as well as cancer and disease. Dysregulation of histone methylation patterns is observed in a variety of human cancers, inflammation,

They identified gene expression profiles typical of different types of neurons newborn neural progenitors and radial glia,

After, they compared the patterns of gene expression in the resulting neurons with cells taken from autopsied brains.

Different patterns of gene expression were recognizable using the direct conversion method, depending on the age of the person they were created from. he neurons we derived showed differences depending on donor age,

said Mertens. nd they actually show changes in gene expression that have been implicated previously in brain aging.

the molecules that function to regulate gene expression that are necessary to make the treatment. e are thrilled to be able to continue development of this promising treatment technique,

which can activate pro-inflammatory gene expression by the immune system, said Chassaing and colleagues. These changes in bacterial expression triggered chronic colitis in mice genetically prone to this disorder,

which plays a key role in controlling gene expression and, thereby helps regulate the cell's development, growth and function."

and gene expression processes in the cell. Using this model the researchers simulated the growth of a well-studied strain of E coli across 333 different growth conditions.

"said Samuel Pfaff, a professor in Salk's Gene expression Laboratory.""These are just raw signals you can see through the eyepiece of a microscope.

#CRISPR brings precise control to gene expression Researchers have demonstrated the exceptional specificity of a new way to switch sequences of the human genome on

-which helps it to maintain gene expression patterns that are put in place during early development. But when the proper functioning of PRC2 is disrupted due to mutations in the PRC2 gene,

where they can change the levels of gene expression. With this technology, we can explore what exactly it is that they're doing

Associate professor Voss said the study revealed that the proteins tightly regulated Hox gene expression in early embryonic development."

and correctly timing Hox gene expression, ensuring the genes were activated at the right time and in the right place,

She said the research also showed that significantly reducing Hox gene expression still allowed normal development,

Transcription factors are proteins that regulate gene expression. Once activated by brassinosteroids, they initiate the production of gibberellin."

#Pancreatic cancer subtypes discovered in largest gene expression analysis of the disease to date Dense surrounding tissue can block drugs from reaching pancreatic cancer tumors,

They were then able to examine gene expression patterns for each type in tissue samples from five different institutions.

"We were able to look at gene expression at a whole new level of resolution, "Lawson said."

"Metastases show stem cell qualities The team compared patterns of gene expression in human cancer cells lodged in different organs of the PDX mice and found stark differences between early-stage and more advanced metastatic colonies.

Insights could lead to targeted therapies The research team performed a proof of principle experiment to demonstrate how valuable information about metastatic gene expression could be for drug development.

where they can change the levels of gene expression. With this technology, we can explore what exactly it is that theye doing

you can get gene expression i e.,, production of therapeutic proteins for several months, Suk says, adding that the nanoparticles did not appear to show any adverse effects,

a transcription factor a protein able to influence gene expression known as Er81. Fast-spiking interneurons are part of a general class of neurons

but also other cellular features such as gene expression, post translational modification, and cell function, said Huang. he acoustic power intensity

DNA methylation is essential for the proper control of gene expression and cell identityhat enables cells with the same genetic material to become, for example, a nerve cell, a muscle cell or a skin cell.

The differences between a muscle cell and a brain cell are attributable to differences in gene expression; that is, which genes are turned on and off.

DNA methylationhe addition of methyl groups to the DNAS an epigenetic mechanism that controls gene expression. In most cases, methylated genes are switched off,

and then amplified the RNA in each single cell to look for gene expression levels. They found that, indeed,

#CRISPR Brings Precise Control to Gene expression Researchers have demonstrated the exceptional specificity of a new way to switch sequences of the human genome on

The team found a similar gene expression profile to that of kidneys of first-trimester human fetuses, for example,

The Weissman team led experiments demonstrating that CRISPR molecules incorporating the Suntag can be used to precisely control gene expression of many genes within the genome.

and responds by activating cellular gene expression programs. Observations that fructose potently activates Chrebp in rodent livers

by jointly analyzing the gene expression and mutational profile data of more than 250 patients collected by the Cancer Genome Atlas consortium.

As the instructions for all cell processes the DNA must be accessible to the cell transcription machinery yet be compressed tightly enough to fit inside the nucleus. Scientists have theorized long that the way DNA is packaged affects gene expression.

and repressing gene expression. or the first time we see that the structure of the chromosomes contributes to gene controlsays Whitehead Member Richard Young who is also a professor of biology at MIT. n the past there have been all kinds of ideas around how the structure might affect gene control

which led us to these domains these super enhancer domains where gene expression enhancement is contained within the loopsays Jill Dowen a postdoctoral researcher in Young lab. Dowen

and CTCF acting as the purse strings to create a DNA loop that cradles proteins enhancing or repressing gene expression.

although they may switch their contents and therefore their effect on gene expression. The researchers plan to study the loop structure

and its effects. think wee filled in a major gap in the understanding of how gene expression is linked to the local organization of chromosomessays Hnisz. t will be exciting to explore

Rappocciolo and her colleagues searched for patterns in gene expression, or the degree to which specific genes are turned on or off."

Nanoflares have been very useful for researchers that operate in the arena of quantifying gene expression. Aurasense, Inc.,a biotechnology company that licensed the Nanoflare technology from Northwestern University,

Hetzer suspects that other nucleoporins also have roles in gene expression control, but cautions that the roles could be very differentach nucleoporin,

and developmental disorders might actually be caused by the ability of these genes to regulate gene expression programs.

sirna has been shown to effectively shut down gene expression in tumor cells grown in the laboratory. But the technique had not been effective in living organisms

The team developed a series of genetic parts that can be used to precisely program gene expression within the bacteria. sing these parts

For future experiments, Ruder is building real-world robots that will have the ability to read bacterial gene expression levels in E coli using miniature fluorescent microscopes.

According to Adaptimmune, the trial is published the first study of lentiviral vector mediated TCR gene expression in humans.

Nanoflares have been very useful for researchers that operate in the arena of quantifying gene expression. Aurasense, Inc.,a biotechnology company that licensed the Nanoflare technology from the university,

Beyond their participation in host defense, increasing evidence suggests that these modifications also play important roles in the regulation of gene expression, virulence,

We found that a typical clonal bacterial population that would otherwise be considered homogeneous using conventional techniques has epigenetically distinct subpopulations with different gene expression patterns"said Gang Fang, Ph d,

and different subpopulations with distinct methylation patterns have distinct gene expressions patterns. This may have contributed to the increasing rate of antibiotic resistance of H. pylori. he application of this new technique will enable a more comprehensive characterization of the functions of DNA methylation and their impact on bacterial physiology.

to regulate gene expression in which the G4 sequences act as sensors of oxidative stress e

#New Cell Structure Finding Might Lead to Novel Cancer Therapies University of Warwick scientists in the U k. say they have discovered a cell structure

and metabolic gene expression in breast cancer patients,"explained Dr. Lee.""These results highlight that 14-3-3s is an important regulator of tumor metabolism,

both on its own and when linked with other molecules responsible for turning genes off, thereby regulating gene expression.

and allows us to determine the gene expression of those highly mobile cells in comparison to the less mobile ones.

and allows us to determine the gene expression of those highly mobile cells in comparison to the less mobile ones.

The electrical signals used in electronics are replaced by molecular signals that control gene expression. It is thus now possible to implant simple genetic"programmes"into living cells in response to different combinations of molecules.

Nanoflares have been very useful for researchers that operate in the arena of quantifying gene expression. Aurasense, Inc.,a biotechnology company that licensed the Nanoflare technology from Northwestern University,

This histone replacement, known as turnover, enables our genetic machinery to adapt to our environment by prompting gene expression,

meaning it fine-tunes gene expression without changing the DNA code we inherit from our parents. The study results revolve around the fact that,

or changes to gene expression caused by external and environmental factors, this work provides a novel conceptual framework for further studies aimed at identifying the molecular underpinnings of neurodevelopmental disease and psychiatric illness. pecifically,

Despite such accumulation, H3. 3-containing nucleosomes remain highly dynamicn a modification-independent mannero control neuronal-and glial-specific gene expression patterns throughout life.

However gene expression studies showed that it is churned actually out by non-neuronal cells called astrocytes.

Initial lab testing suggests that a Bub1 inhibitor can very specifically target Bub1 without causing damage to other parts of the cell. hen you look at gene expression in cancer,

The researchers speculate that byproducts from other bacteria infections in other diseases might change gene expression using similar mechanisms.

of mouse Ngly1 gene expression. Published in Proceedings of the National Academy of Science the paper details how lack of the Ngly1 protein results in the incomplete removal of the sugar portion of glycoproteins--a process called deglycosylation.

It provides data on the gene expression profiles of hundreds of individual cells in a single experiment producing an exact picture of the individual cell types.

or biological processes can be taken into account making it possible to create a more accurate picture of gene expression in different cell types

If all you have is gene expression data from single cells you need a way to identify

The electrical signals used in electronics are replaced by molecular signals that control gene expression. It is thus now possible to implant simple genetic"programmes"into living cells in response to different combinations of molecules.

Small cruciforms enable DNA replication and gene expression, essential for human life. But scientists have suspected also these small cruciforms--a structure of DNA itself--to be linked to mutations that can elevate cancer risk.

which are regulated mainly at the protein level rather than the gene expression level. Instead, the researchers developed a sophisticated protein-tracking technique based on the presence of a hypoxia-responsive protein called Hif-1alpha.

"This fate-mapping approach, based on protein stabilization rather than gene expression, is an important tool for studying hypoxia in the whole organism.

but the fact that we've demonstrated it can be stable in living tissue shows that it could regulate gene expression and potentially signal other events in cells.'

its position in the genome suggests that it has a key role in the regulation of gene expression.'

high throughput single-cell gene expression and time-lapse imaging simultaneously in the same human embryo.

Through single cell gene expression profiling--the measurement of the activity of hundreds of genes at once--Chavez

The process has increased the speed that researchers can note the differences in gene expression among genomes

Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases

but the fact that wee demonstrated it can be stable in living tissue shows that it could regulate gene expression and potentially signal other events in cells.

its position in the genome suggests that it has a key role in the regulation of gene expression.

The team developed a series of genetic parts that can be used to precisely program gene expression within the bacteria. sing these parts

Condensin recognizes unwound DNA segments produced by gene expression and restores them to double-stranded DNA.

and were produced by gene expression (or transcription), and that ssdna amount was increased further in condensin-deficient cells.

and an altered gene expression program leads to a reprogramming of leukemic cells to an early, stem-cell like, developmental stage,

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