Using a cell phone to detect and quantify bacteriae. coli and S. aureus are the most common bacterial pathogens that cause food poisoning,
These'organoid'cultures are amenable to large-scale drug screens for the detection of genetic changes associated with drug sensitivity
Moving forward, the researchers plan to expand the panel of existing colon organoids as well as develop an organoid biobank for other tumor types."
When combined, the three proteins formed a robust panel that can detect patients with stages I-II pancreatic cancer with over 90 per cent accuracy.
This is a biomarker panel with good specificity and sensitivity and we're hopeful that a simple,
"This paves the way for the use of more sophisticated printers to create structures with much finer resolution."
"Electrically stimulating the retina excites all of these cells at the same time, which is very different from how these cells respond to real visual input."
paving the way for high-density storage to move from hard disks onto integrated circuits. The advance, to be reported in the Proceedings of the National Academy of Sciences,
could lead to computers that turn on in an instant and operate with far greater speed and significantly less power.
an associate professor of electrical engineering and computer sciences, has found that a slight tilt of the magnets makes them easy to switch without an external magnetic field.
we want to be able to manufacture a computer chip that includes memory so that it is close to the computational action,
which is why magnets have not yet been integrated onto computer chips. Instead, there are separate systems for long-term magnetic memory.
These include a computer's hard disk drive where data are stored, and the various kinds of random-access memory,
or RAM, on the integrated circuits of the central processing unit, or CPU, where calculations and logic operations are performed.
A large portion of the energy used in computing is spent on transferring data from one type of memory to another.
Doing that quickly takes more energy and generates more heat. In past research Salahuddin and his colleagues found that directing electrical current through the rare metal tantalum creates polarity in magnets without an external magnetic field.
The rats were asked to choose between two identical visual shapes by pressing their nose against one of them on a touchscreen (similar to an ipad
"Moreover, most functional screens are carried out in mouse ESCS. The only functional screen on human ESCS was published in 2010 from our laboratory at the GIS.
This latest study was performed also on human ESCS, making it more clinically relevant than studies using mouse ESCS."
"Co-lead author Research Fellow Dr Liang Hongqing at GIS'Stem Cell and Regenerative Biology added,
The superior performance of the new UED system is due to a very stable"electron gun"originally developed for SLAC's X-ray laser Linac Coherent light Source (LCLS), a DOE Office of Science User Facility.
#New research may enhance display, LED lighting technology Recently, quantum dots (QDS)--nano-sized semiconductor particles that produce bright, sharp,
color light--have moved from the research lab into commercial products like high-end TVS, e readers, laptops,
and photonic crystal technology, could lead to brighter and more efficient mobile phone, tablet, and computer displays, as well as enhanced LED lighting.
With funding from the Dow chemical Company, the research team, led by Electrical & Computer engineering (ECE) Professor Brian Cunningham, Chemistry Professor Ralph Nuzzo,
They then used electrohydrodynamic jet (e-jet) printing technology to precisely print the QD-embedded polymers onto photonic crystal structures.
and more efficient displays.""Since screens consume large amounts of energy in devices like laptops, phones,
and tablets, our approach could have a huge impact on energy consumption and battery life, "she noted."
"If you start with polarized light, then you double your optical efficiency, "See explained.""If you put the photonic crystal-enhanced quantum dot into a device like a phone or computer,
then the battery will last much longer because the display would only draw half as much power as conventional displays."
"To demonstrate the technology, See fabricated a novel 1mm device (aka Robot Man) made of yellow photonic crystal-enhanced QDS.
and evaluated the penetration capability by using mouse brains in vitro/in vivo. In addition, as an actual needle application, we demonstrated fluorescenctce particle depth injection into the brain in vivo,
such as Microsoft's Kinect controller for video games, have become widely used 3-D sensors. Now, a new imaging technology invented by Carnegie mellon University and the University of Toronto addresses a major shortcoming of these cameras:
"We don't need new image-processing algorithms and we don't need extra processing to eliminate the noise, because we don't collect the noise.
"One prototype based on this model synchronizes a laser projector with a common rolling-shutter camera-the type of camera used in most smartphones
It also could be incorporated readily into smartphones. The researchers will present their findings today at SIGGRAPH 2015, the International Conference on Computer graphics and Interactive Techniques,
if only briefly, noted Kyros Kutulakos, U of T professor of computer science.""Even though we're not sending a huge amount of photons, at short time scales,
if other camera hardware is used, the mathematical framework developed by the team can compute energy-efficient codes that optimize the amount of energy that reaches the camera.
In addition to enabling the use of Kinect-like devices to play videogames outdoors, the new approach also could be used for medical imaging,
and Matthew O'Toole, a U of T Ph d. computer science student. The research was supported by the National Science Foundation, the U s army Research Laboratory,
"The study links a family of enzymes--molecules that act as biological catalysts--known as polyketide synthases (PKS) directly to a complex series of chemical reactions that ultimately add sulfur to leinamycin, a member of the polyketide family of natural products."
rather than just relying on traditional chemical screens, "says Hubbard, an assistant professor of pharmacology in the University of Alberta's Faculty of medicine & Dentistry."
Much like how a computer programmer edits computer code, scientists could one day replace a person's broken
but constructing enough of them to perform a useful computation is difficult. In the usual approach to quantum computing, quantum gates are applied in a specific order, one gate before another.
Surprisingly, this effect can be used to reduce the total number of gates required for certain quantum computations.
"In fact, we were able to run a quantum algorithm to characterize the gates more efficiently than any previously known algorithm,
The scientists were able to accomplish a computation with an efficiency that cannot be achieved within the old scheme of quantum computing.
This work opens a door for future studies on novel types of quantum computation. Although its full implications are still unknown,
"This new technique is sort of a twist on a red-eye reducing camera flash, where the first flash causes the subject's pupils to close
and the second illuminates the scene.""In their setup, instead of xenon-powered flash the team used two LEDS.
when it flashes (you could say this LED gives the quantum dots red eye). At the same time, a second, different color LED flash illuminates metallic orientation marks placed on the surface of the semiconductor wafer the dots are embedded in.
Then a sensitive camera snaps a 100-micrometer by 100-micrometer picture. By cross-referencing the glowing dots with the orientation marks,
Their coordinates in hand, scientists can then tell the computer-controlled electron beam lithography tool to place any structure the application calls for in its proper relation to the quantum dots,
This work was performed in part at NIST's Center for Nanoscale Science and Technology (CNST), a national user facility available to researchers from industry, academia and government t
"Scientists from the Heidelberg Institute for Theoretical Studies (HITS) performed the computational data analysis for this research.
#Fiber-like light emitting diodes for wearable displays A research team at Korea Advanced Institute of Science
and Technology (KAIST) has developed fiber-like light emitting diodes, applicable to wearable displays. Professor Kyung-Cheol Choi and his research team from the School of Electrical engineering at KAIST have developed fiber-like light emitting diodes,
which can be applied in wearable displays. The research findings were published online in the July 14th issue of Advanced Electronic Materials.
Traditional wearable displays were manufactured on a hard substrate, which is attached later to the surface of clothes.
Such technique has posed limitations in applying it for wearable displays because inflexible displays were not adequate in practice,
and the characteristics of fabric were ignored. For a solution, the research team discarded the tradition of creating light emitting displays on a plane board.
Instead, they focused on fibers, a component of fabrics, and developed a fiber-like light emitting diode that has the characteristics of both fabrics and displays.
The essence of this technology, the dip coating process, is to immerse and extract a three dimensional (3-D) board that looks like a thread in a solution.
The researchers said that this technology would accelerate the commercialization of fiber based wearable displays
we can lower the barrier of wearable displays to enter the market.""The first author of the published paper, Seon-Il Kwon, added,
"This technology will eventually allow the production of wearable displays to be as easily as making clothes
"They can just email me,"said Wilson, "and we'll send them the assay, and then they can do it in their own lab
In some ways it's making genetic testing open source.""The development of the new test is an example of Stanford Medicine's focus on precision health,
"This is a remarkable evolutionary solution for'social networking'in large colonies, "Ray explained.""A more volatile body odor cue would be confusing to associate with an individual
#New optical chip lights up the race for quantum computer The microprocessor inside a computer is a single multipurpose chip that has revolutionized people's life,
allowing them to use one machine to surf the web, check emails and keep track of finances.
Now, researchers from the University of Bristol in the UK and Nippon Telegraph and Telephone (NTT) in Japan, have pulled off the same feat for light in the quantum world by developing an optical chip that can process photons in an infinite number
of ways. It's a major step forward in creating a quantum computer to solve problems such as designing new drugs
and performing otherwise intractable mathematics that aren't possible for super computers. Arraysince before Newton held a prism to a ray of sunlight and saw a spectrum of colour,
much like they operate any other piece of software on a computer. They no longer need to convince a physicist to devote many months of their life to painstakingly build
because the world's leading quantum photonics group teamed up with Nippon Telegraph and Telephone (NTT), the world's leading telecommunications company.
and engineering expertise in the telecommunications industry. It's a model that we need to encourage
as well as superstrong composites--like the ones used in phone cases and body armor. Each new combination of atom-thick layers presents new properties
and reduce costs The process replaces the chemical tablets phosphine and methyl bromide, which are toxic and carcinogenic,
The physicochemical expert explains that the common spraying method is used in doses of four tablets of phosphine per ton of grain."
making a tea, tablets, capsules or powders that can be added to the water. We hope to get the patent later this year
based on a natural phenomenon known in mathematics as fractals. These are irregular shapes which recur repeatedly to form objects such as snowflakes,
and their design was done traditionally by manufacturing but now, with 3d printing, computer manufacturing and more laser technology,
SSRL and LCLS are DOE Office of Science User Facilities. The researchers combined and analyzed hundreds of X-ray images from about 150 protein crystals to reveal the atomic-scale details of the joined structure.
Then, using a complex computer algorithm, they determined the responses of all possible combinations of the segments.
This mechanism may act as a firewall, shutting down the immune response before it gets out of hand. However, from a clinical standpoint, this discovery could lead to more effective cancer immunotherapies,
Loyola is the only site in Illinois participating in a clinical trial in which the device is being implanted in lower-risk patients.
SURTAVI is being conducted in 76 sites in eight countries for patients who do not qualify for the transcatheter valves commercially.
and converts'breath signals'into words using pattern recognition software and an analogue-to-digital converter.
and Dr Kaddour Bouazza-Marouf, Reader in Mechatronics in Medicine, said the device learns from its user,
It allows the user to control how he or she wishes to communicate--effectively enabling them to create their own language by varying the speed of their breathing.
"What we are proposing is a system that learns with the user to form an effective vocabulary that suits the person rather than the machine,
#New embryo image processing technology could assist in IVF implantation success rates A collaboration between biologists
and engineers at Monash University has led to the development of a new noninvasive image processing technique to visualise embryo formation.
"If in the future, we can combine our new image processing technique with non-harmful dyes that can label the membranes of human embryos,
and expensive mouse avatars that are created by injecting human tumor cells into mice.""This is really the first time that it's been demonstrated that you can use a rapid methodology like this to spatially define cancer cells and macrophages,
What sets the team's model apart from mouse avatars and hard plastic plates is that it can replicate much more accurately the sizes and shapes of the microenvironment within the patient's problem area.
Joel Yang and Zhaogang Dong at the A*STAR Institute of Materials Research and Engineering, together with colleagues at the A*STAR Institute Of high Performance Computing and other institutes in Singapore, investigated controlling the traveling
By modeling this process on a computer, the researchers found a good match with the experimental results.
Another key advance is the use of active, inexpensive catalysts for fuel production. The photoanode requires a catalyst to drive the essential water-splitting reaction.
Rare and expensive metals such as platinum can serve as effective catalysts, but in its work the team discovered that it could create a much cheaper,
This catalyst is among the most active known catalysts for splitting water molecules into oxygen
We have demonstrated for the first time experimentally that liquid droplets can be highly mobile when in the Wenzel state."
Our idea is to solve these problems by enabling Wenzel state droplets to be said mobile
In order to make Wenzel state droplets mobile, the researchers etched micrometer scale pillars into a silicon surface using photolithography and deep reactive-ion etching,
Starting with a pool of around 10 billion unique monobodies, they used directed evolution techniques to identify a group of monobodies that bound near the active site of beta-galactosidase.
The monobody partially blocks the active site of the enzyme and prevents it from accepting large sugars as a substrate--thereby forcing it to produce only short sugar chains."
#DNA-guided 3-D printing of human tissue is unveiled Arraythere are few limits to the tissues this technology can mimic,
"Building functional models of the complex cellular networks such as those found in the brain is probably one of the highest challenges you could aspire to,
showing that samples of brain tissue from two human MSA patients were able to transmit the disease to a mouse model for Parkinson's disease,
and that infected mouse brain tissue could itself spread the disease to other mice. The discovery that alpha-synuclein prions can transmit MSA raises a public health concern about treatments
in contrast to the 120 days it takes for the disease to spread to mouse models."
"You have to let the mouse models develop for such a long time that research on cures is really slow to progress.
San diego demonstrated a new wireless communication technique that works by sending magnetic signals through the human body.
and more secure way to communicate information between wearable electronic devices, providing an improved alternative to existing wireless communication systems,
such as smart watches, fitness trackers and health monitors. All of these devices will need to communicate information with each other.
Currently, these devices transmit information using Bluetooth radios, which use a lot of power to communicate. We're trying to find new ways to communicate information around the human body that use much less power,
a professor in the Department of Electrical and Computer engineering at UC San diego who led the study.
Communicating magnetic signals through the human body The new study presents a solution to some of the main barriers of other wireless communication systems:
Bluetooth technology uses electromagnetic radiation to transmit data, however these radio signals do not easily pass through the human body
and therefore require a power boost to help overcome this signal obstruction, or"path loss."
Researchers showed that the path losses associated with magnetic field human body communication are upwards of 10 million times lower than those associated with Bluetooth radios."
"This technique, to our knowledge, achieves the lowest path losses out of any wireless human body communication system that's been demonstrated so far.
This technique will allow us to build much lower power wearable devices, "said Mercier. Lower power consumption also leads to longer battery life."
"A problem with wearable devices like smart watches is that they have short operating times because they are limited to using small batteries.
With this magnetic field human body communication system, we hope to significantly reduce power consumption as well as how frequently users need to recharge their devices,
Since this technique is intended for applications in ultra low power communication systems the transmitting power of the magnetic signals sent through the body is expected to be many times lower than that of MRI SCANNERS and wireless implant devices.
Another potential advantage of magnetic field human body communication is that it could offer more security than Bluetooth networks.
Because Bluetooth radio communicates data over the air, anyone standing within 30 feet can potentially eavesdrop on that communication link.
To put this in the context of a personal full-body wireless communication network, information would neither be radiated off the body nor be transmitted from one person to another."
when you're using your wearable devices to transmit information about your health, "said Park. Demonstrating magnetic communication with a proof-of-concept prototype The researchers built a prototype to demonstrate the magnetic field human body communication technique.
The defect gene was identified through extensive computer analysis and Ph d. candidate Tuva Barøy subsequently worked with collaborators in The netherlands to find out how the gene defect affects cell function.
shift work, jet lag and even the blue-tinged light emitted by cell phones and tablets. Typically, sleep researchers have a hard time studying sleep deprivation and the circadian cycle separately,
#New technology transforms cell phone into high-powered microscope New technology that transforms a cell phone into a powerful,
and feel to a protective phone case, makes use of a smart phone's camera features to produce high-resolution images of objects 10 times smaller than the thickness of a human hair,
says Gerard Coté, professor of biomedical engineering and director of the Texas A&m Engineering Experiment Station's Center for Remote Health Technologies and Systems.
Coté's development of the instrument, known as a mobile-optical-polarization imaging device (MOPID), is detailed in the online scientific journal Scientific Reports,
when observed through the phone's camera lens--enabling an instant, accurate diagnosis. While polarized light has been preferred the option for malaria detection due to its increased sensitivity,
"What we've achieved with MOPID is the design of a polarized microscope platform using a cell phone,
Coté's solution takes advantage of existing mobile phone technology and networks--something to which a whopping 75 percent of the world has access.
This ever-increasing access to mobile networks and the fact that most mobile phones are equipped with advanced camera features make mobile phones the ideal platform for advanced imaging applications such as MOPID,
and specificity to detect malaria with both ios -and Android-based devices and requires less user expertise than traditional microscopy,
Coté says. That user friendly aspect, coupled with the system's portability and expected low cost of about $10 per unit, makes it an easily adoptable technology in low-resource areas ravaged by malaria,
he adds. What's more, analysis of a blood sample can be made instantaneously with the patient in the field without the need for a mobile network,
says Coté, who notes that a network is required only for transmitting the images to a central location for further analysis or storage."
The technology was among the top award winners in the Texas instruments Innovation Challenge this past summer.
The technology, developed in collaboration with Texas instruments, represents a growing interest in the development of high-tech sign language recognition systems (SLRS) but unlike other recent initiatives,
and the videos or images captured may be considered invasive to the user's privacy. What's more,
because these systems require a user to gesture in front of a camera, they have limited wearability--and wearability,
This sensor plays a major role in discriminating different signs by capturing the user's hand orientations and hand and arm movements during a gesture.
In Jafari's system both inertial sensors and electromyographic sensors are placed on the right wrist of the user where they detect gestures
and send information via Bluetooth to an external laptop that performs complex algorithms to interpret the sign
and display the correct English word for the gesture. As Jafari continues to develop the technology,
he says his team will look to incorporate all of these functions into one wearable device by combining the hardware and reducing the overall size of the required electronics.
so that he or she can understand what is being signed simply by reading the screen of their own device.
In addition, because many labs use their own software to examine CNVS, there is little consistency in how researchers analyze their results.
web-based program automatically processes sequence data, maps the sequences to a reference genome, and creates CNV profiles for every cell that can then be viewed with a user friendly graphical interface.
In addition, Gingko constructs phylogenetic trees based on the profiles, allowing cells with similar copy number mutations to be grouped together.
Schatz and his team named their software after the gingko tree which has documented many well therapeutic benefits."
and deploy it on site.""The researchers use a particular origami technique called Miura-ori folding.
Larger-scale applications could combine metal or plastic panels with hinges. Next, the researchers plan to explore new combinations of tubes with different folding angles to build new structures.
Single photons are important in the field of quantum information technology where, for example, they are used in quantum computers.
Quantum cryptography and quantum communication are two potential areas of application for single-photon sources.
These technologies could make it possible to perform calculations that are far beyond the capabilities of today's computers.
what are called CRISPR libraries instead of RNAI screens.""This is a major finding with translational implications for this infection that causes so many deaths worldwide,
and wearable devices,"said Panat. While Panat is excited about the work and hopes it will be commercialized, the researchers also want to better understand the metal's behavior."
so we needed to marry the right data analysis technique to the right problem, "Moffitt said.
A team of engineers and an artist developed an array of small solar cells that can tilt within a larger panel
from the standpoint of the person who's putting this panel up, nothing would really change,
"When the panel is at an angle, it looks smaller. By designing an array that tilts
and Shtein how to create them in paper using a plotter cutter. Lamoureux then made more precise patterns in Kapton,
it is almost as good as a conventional single-axis tracker, offering a 36 percent improvement over a stationary panel.
Conventional trackers produce about 40 percent more energy than stationary panels under the same conditions,
Using computer-generated model speeds up the drug discovery process The new drug-like compounds discovered by Vogel
and her co-authors offer hope that using a computer-generated P-gp model, explained here http://bit. ly/1lvmr7a,
Researchers virtually screened 15 million drug-like compounds via SMU supercomputer The SMU researchers discovered the three hit compounds after virtually screening more than 15 million small drug-like compounds made publically available
San francisco. Using SMU's Maneframe high performance computer, Wise ran the compounds through a computer-generated model of P-gp.
The virtual model, designed and built by Wise, is the first computational microscope of its kind to simulate the actual behavior of P-gp in the human body,
Using computer-generated model speeds up the drug discovery process The new drug-like compounds discovered by Vogel
and her co-authors offer hope that using a computer-generated P-gp model, explained here http://bit. ly/1lvmr7a,
Researchers virtually screened 15 million drug-like compounds via SMU supercomputer The SMU researchers discovered the three hit compounds after virtually screening more than 15 million small drug-like compounds made publically available
San francisco. Using SMU's Maneframe high performance computer, Wise ran the compounds through a computer-generated model of P-gp.
The virtual model, designed and built by Wise, is the first computational microscope of its kind to simulate the actual behavior of P-gp in the human body,
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