Targeting cancer Efforts to create cancer therapies tailored to a patient's genetic make-up were boosted by promising clinical-trial results reported on 7 december (J. Baselga et al.
) The trial was conducted on women with advanced forms of breast cancer that involved mutations in the HER2 gene,
which drives about 20%of breast-cancer cases. Those given the experimental monoclonal antibody pertuzumab and the widely used drug trastuzumab (Herceptin), together with chemotherapy, gained an extra 6-month lull in disease progression compared with women receiving only chemotherapy and trastuzumab.
which can cause kidney and liver damage and bladder cancer. Medicinal use of the herb probably explains high rates of bladder cancer in Taiwan,
according to a paper published this week in Proceedings of the National Academy of Sciences2. At least one of the four medicines that contained Aristolochia DNA also contained aristolochic acid.
and pharmaceutical laboratories, has bred so far about 275 Â pigs some with cystic fibrosis, others with heart disease, arrhythmia or cancer,
and genetically modifying plants to feed the world s population. go. nature. com/m128l22 August The governing board of the Cancer Prevention
Texas grant review The Cancer Prevention and Research Institute of Texas (CPRIT) in Austin has appointed a compliance officer to review
Cancer vaccine The biotech firm behind the first approved cancer vaccine will slash 41%of its workforce, after tepid sales of its Provenge (sipuleucel-T) therapy for some prostate cancers.
Horwitz (pictured) created AZT in the 1960s to combat cancer, but he shelved the drug after it showed little efficacy against the disease.
but he did go on to produce treatments for diseases such as cancer at the Wayne State university School of medicine in Detroit, Michigan,
Cancer ambitions A leading US cancer centre said last week that it will spend up to US$3 Â billion over the next ten years on a programme to significantly increase the odds of surviving eight cancers.
Under the Moon shots initiative, research teams at the MD Â Anderson Cancer Center in Houston,
Texas, will focus on cancer of the prostate, lung and ovary, and on a type of breast cancer as well as melanoma, two leukaemias and a related blood syndrome.
See go. nature. com/lrevbl for more. XMRV ruled out The retrovirus XMRV is linked not to chronic fatigue syndrome (CFS
It reported that the rats developed higher levels of cancers had larger cancerous tumours and died earlier than controls.
Subsequent epidemiological studies involving tens of thousands of people have looked for links between acrylamide and various forms of cancer in humans
among those who had smoked never, women consuming about 40 â°micrograms of acrylamide per day doubled their risk of developing cancers of the womb
saying that Geron s cancer therapeutics are a better investment. See go. nature. com/tihbe6 for more.
Roundup, showed increased incidences of cancer (G.-E. SÃ ralini et al. Food Chem. Toxicol. http://doi. org/jgq;
including Alzheimer s disease, cancer and muscular dystrophy. This work will be enriched by the discovery, reported in the genome paper,
Mess in Texas The Cancer Prevention and Research Institute of Texas (CPRIT) announced the freezing of an US$11-million commercialization grant to Peloton Therapeutics in Dallas on 29 november,
The finding comes on the heels of months of controversy about an $18-million unreviewed CPRIT grant to the University of Texas MD Anderson Cancer Center in Houston (see Nature 486,169-171;
and BRCA2 gene variants linked to inherited breast and ovarian cancer. See go. nature. com/jbqdxl for more.
Lawsuit settlement Cancer researcher Philippe Bois has settled a lawsuit against the US Department of health and human services (DHHS) over scientific misconduct, according to an announcement on 18 Â April.
such as the pesticide dichlorodiphenyltrichloroethane (DDT) and the herbicide Agent orange, can cause diseases such as cancers, neurological disorders, reproductive dysfunction and birth defects.
last year regulators shot down another such drug, dapagliflozin, citing cancer concerns. Source: US National Snow and Ice Data Centera record low in the extent of sea ice in the Arctic last September has been followed by a record refreezing of uncovered ocean surface,
and"the increasing dominance of first-year ice in the Arctic. 6-10 april Discussions on mapping the epigenomes of cancer take place at the American Association for Cancer Research s annual meeting in WASHINGTON DC. go. nature. com
Li Bocordgrass has been spreading there"like a cancer, says reserve director Tang Chendong, so far consuming more than 10%of the wetland.
the company has sued two competitors for infringing different patents on tests for the cancer-related genes BRCA1 and BRCA2.
Hua Jun Zhao, from China, had been under investigation for allegedly stealing patented cancer-research material,
Myriad, a medical diagnostics company in Salt lake city, Utah, sued Ambry in July for infringing patents that Myriad holds on tests for cancer-associated mutations in the BRCA1 and BRCA2 genes.
) Cancer cash On 21 september, philanthropists Phil and Penny Knight announced that they would donate US$500 million to cancer research at Oregon Health
The money would support science at the university s Knight Cancer Institute, to which the couple gave a $100-million donation in 2008.
and Drug Administration (FDA) approved on 13 Â November a breakthrough therapy to treat a rare blood cancer called mantle-cell lymphoma.
3 february The World health organization releases its Third world Cancer Report, six years after its previous publication. The latest report will include updated trends in cancer incidence,
prevalence and mortality. go. nature. com/x39hvk
Plant killers protect rainforest diversityvoracious pests may be foes of individual plants, but they can benefit forests.
and is being tested at the Memorial Sloan-Kettering Cancer Center in New york city to help physicians decide how to diagnose
Cancer donation Six US research centres have received a combined donation of US$540 Â million from the estate of late shipping magnate Daniel Ludwig.
Harvard university, the Massachusetts institute of technology, Memorial Sloan-Kettering Cancer Center, Stanford university and the University of Chicago. Announced on 6 Â January,
the donation brings the total contribution to cancer research by Ludwig and his estate to $2. 5 Â billion.
and cancer progression. go. nature. com/rs9oyb15-17 january The 8th Human Amyloid Imaging meeting in Miami,
concluded that the evidence that smoking causes lung cancer and other illnesses was overwhelming. The Surgeon general is a spokesperson for the US Department of health.
Physician Michele Bloch, chief of the Tobacco Control Research Branch at the US National Cancer Institute (NCI) in Bethesda, Maryland, calls the study by Levy and colleagues"powerful
The European commission and Cancer Research UK made the most links, according to an analysis by the publication Scibx.
Maybe we should stop spending money on cancer programs as many different types of cancers have had very little success in curing them.
but might be present on one-to 10-year timescales âÂ#Âarguably important enough to be a concern in terms of skin cancer rates Tarduno said.
That cosmic radiation blasting the Earth's surface could cause genetic mutations and cancers. Yet when palaeontologists scoured the fossil records looking for signs of mass extinctions
despite the fact that it has been linked to cancer heart disease and birth defects. Al Mauroni director of the USAF counterproliferation center in Alabama and author of Chemical Demilitarization:
inducing more cancer deathes and mutations. Here comes the MUTANTS! HERE COMES THE MUTANTS S
-when-it-was contaminated-with-cancer-virus. htmlknowing now what we know about vaccines and medicine you think our previous attempts at vaccines are full proof?
and have a high tendency to get cancer over their lifespan under normal conditions. One study shows over 80%of males and 70%of females get cancer during their lifetimes.
In other words SÃ Â ralini is accused of scientific malpractice for not including a high enough sample of rats in the study to control for naturally occurring tumors and cancers.
Next study TANGSTEN? TANGSTEN you may have missed the comment at the top of the article in the second link you provided:
Deficiencies in these vital nutrients are associated with increased rates of osteoporosis cancer and other diseases.
depression autism infertility cancer and Alzheimer s disease. ÃÚ à The glyphosate-resistance of GMO corn has encouraged such an over-abundance of glyphosate-based herbicides to be dumped into the environment worldwide that nature has started to respond in kind with the evolution of âÂ#Âoesuperweeds.
GMO corn contains an extremely high level of formaldehyde a chemical linked to adverse health effects and various forms of cancer.
From characterization of materials to cancer therapy including energy production. Associating nuclear research to weapons is naã Â ve.
whether a painkiller an anti-inflammatory or a new cancer pill must pass a liver tox.
but when it comes to procedures like cutting out cancer nothing matches the real experience. Rather than printing healthy tissue bioprinters could build organs with tumors
I don't want anymore ALTERED FOODS being made we have enough people dying of CANCER & other processed food ailments for a lifetime?
and the greatest maladies we face are used ones people to never live long enough to get such as cancer and Alzheimer's.
and SV40 has been proven to cause cancer in animals. Okay that's just old news fair enough let's pretend everything is safe now.
and broccoli have lower rates of cancer. If grocers maintained day-night cycles for their wares they might maintain more healthful chemicals for shoppers to consume the biologists wrote.
I wonder if there might be side effects like an increased potential for cancer...I wonder how long it would take to regrow such a large appendage...
when it interacts with cancer. I do wonder if there are a relative unlimited amount of the stem cells in your bone marrow
but in reality those levels could never be reached. http://www. druglibrary. org/schaffer/library/mj overdose. htmmarijuana also doesn't cause cancer. http://www. washingtonpost. com/wp-dyn/content/article/2006/05/25
In this transit period radiation cancer deaths will multiply into the 100k yearly for humanity. See these links:
And at the same time they have managed to dump it into our environment anyway slowly poison us all as the fluorosis of our bones teeth organs causes many many medical conditions that we simply write off as unfortunate cases of cancer arthritis allergies old age etc..
Cancer-causing radiation such as Iodine-131 Cesium-137 Tritium Krypton Strontium...2. A NEW Gallup Poll says over 70%of Americans want more WIND
and Ecological Consequences of Fukushima in which the amount of cancers caused by radiation in our food
The total amounts of deaths birth defects miscarriages heart attacks cancers etc. due to nuclear radiation is in the millions upon millions;
Fukushima is expected by Dr. Helen Caldicott M d. to cause at least 1 million deaths by cancer due to radioactivity already released.
If a Magnitude 8 earthquake strikes Japan before a fuel pool dangling 100 feet in the air is secured the resulting radioactivity is expected to be at least 40 times that of Chernobyl causing untold millions of cancers across the Northern hemisphere.
Dr. Yablokov found ONE MILLION deaths due to Chernobyl. 5. Dr. Wing found that lung cancers rose dramatically in people exposed to the Three Mile Island radiation plume. 6. Dr. Gould
coast. 9. Dr. Gofman did studies on the increases of breast cancer due to nuclear radiation. 10.
Even the pro-nuclear World health organization says breast cancer and leukemia will increase after Fukushima and predicts a 70%increase thyroid cancer risk in females exposed to Fukushima radiation as infants. 11.
It's not just cancers and death that nuclear radiation causes. Dr. Wertelecki found teratomos conjoined twins mocrophthalmia NTD microcephaly horrible birth defects and a decrease in cognitive skills due to Chernobyl.
This is just a TINY example of the cancers deaths birth and health effects caused by nuclear radiation.
Again I highly recommend everyone watch the speakers at the Fukushima Symposium to learn more. www. totalwebcasting. com/view/?
http://en. wikipedia. org/wiki/Nuclear and radiation accidentsthe*4000 cancer number associated with Chernobyl is the number of cancers--not deaths--attributed to Chernobyl.
thyroid cancers in children and adolescents. Thyroid cancer is highly treatable and the average 5-year survival rate is about 97%.
%If it's caught early as is likely in the Chernobyl-affected area where intensive monitoring has been ongoing the survival rate is virtually 100%.
Although radiation may cause cancer at high doses and high dose rates public health data do not absolutely establish the occurrence of cancer following exposure to low doses and dose rates âÂ#Âbelow about 10000 mrem (100 msv).
Studies of occupational workers who are exposed chronically to low levels of radiation above normal background have shown no adverse biological effects. http://www. nrc. gov/about-nrc/radiation/health-effects/rad
-exposure-cancer. htmlhere's a graphic comparison of different levels of radiation dosages: http://xkcd. com/radiation/And here's an MIT study from 2012 which suggests that the established long-term radiation dosage limits may be 10 times too conservative due to the way the cancerous effects are measured;
and are not cancer causing and create jobs with medical benefits! People with good paying skill jobs pay taxes too and the government needs it taxes
Without mutations there would be no cancer. While most mutations result in the untimely death of the organism some organism survive these mutations
Coffee may also lower the risk of liver cancer by around 40%(26 27. Bottom line:
Coffee appears to be protective against certain liver disorders lowering the risk of liver cancer by 40%and cirrhosis by as much as 80%.
Our planet has about a 30 percent chance of getting hit by a Tunguska-sized 40 meter asteroid in the next 100 years--compare that to the 23 percent chance an American has of dying of cancer.
Based on the idea that our hunter-gatherer ancestors didn't suffer from the pains of obesity cancer gout
âÂ#Âoebased on the idea that our hunter-gatherer ancestors didn't suffer from the pains of obesity cancer gout
The contamination was so widespread that experts have estimated between 4000 and 93000 extra cancer deaths have occurred
At the time Thomas Platts-Mills and Scott Commins both allergy specialists at the University of Virginia Health System were trying to understand why some of their patients had developed a severe allergic reactions to cetuximab an intravenous cancer-fighting drug.
and when you burn them you get a whole cocktail of cancer-causing stuff. Puckett estimated that just more than half of the material processed in Guiyu actually got recycled judging from the tons of plastic leaded glass and burned circuit boards discarded near waterways and in open fields.
In 2010 The Economist honored him with one of its awards for energy and the environment (along with Steve jobs and Harald zur Housen a Nobel-winning cancer researcher).
and even breast cancer cells and possess anti-malaria and antibacterial properties. The study found that chemicals isolated from fungi in three-toed sloths were deadly for parasites that cause malaria and Chagas disease (Plasmodium falciparum and Trypanosoma cruzi respectively.
Several of the chemicals isolated from the fungi also showed strong activity against human breast cancer cells. a
#100 Years Of Smoking Studies In Popular Sciencefifty years ago tomorrow then-U s. Surgeon general Luther Terry held a press conference announcing that among other ills smoking caused lung cancer.
the number of scientific studies the U s. surgeon general's advisory committee examined before declaring that smoking caused lung cancer laryngeal cancer and chronic bronchitis17. 7 million:
A chain-smoking doctor among Terry's expert report authors was diagnosed with lung cancer within a year of the surgeon general's announcement NPR reports.
Fast-forwarding to the years preceding the 1964 surgeon general's report scientists were gathering more rigorous evidence that smoking causes various illnesses including lung cancer.
The U s. Public health Service for example has reported that among veterans who died from lung cancer over a certain period about 10 times as many had been smokers igarette smokers s nonsmokers.
After a 20 percent plunge immediately following the lung cancer warning tobacco sales were back to normal it reported.
Cancer therapies similarly are dependent on the availability of effective antimicrobials. Ordinary infections will kill otherwise healthy people.
when epigallocatechin gallate (EGCG) the major extractable polyphenol in green tea and the most biologically active when diluted in skim milk or other milk complexes remains bioactive and continues to reduce colon cancer cell proliferation in culture
#Diet rich in tomatoes may lower breast cancer riska tomato-rich diet may help protect at-risk postmenopausal women from breast cancer according to new research accepted for publication in The Endocrine Society's Journal
Breast cancer risk rises in postmenopausal women as their body mass index climbs. The study found eating a diet high in tomatoes had a positive effect on the level of hormones that play a role in regulating fat and sugar metabolism.
while she was a postdoctoral fellow with Electra Paskett Phd at The Ohio State university Comprehensive Cancer Center--Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.
and vegetables would promote breast cancer prevention in an at-risk population. The longitudinal cross-over study examined the effects of both tomato-rich and soy-rich diets in a group of 70 postmenopausal women.
Researchers originally theorized that a diet containing large amounts of soy could be part of the reason that Asian women have lower rates of breast cancer than women in the United states
#Study documents secondhand exposure to nicotine from electronic cigaretteselectronic cigarettes when used indoors may involuntarily expose non-users to nicotine according to a study led by Maciej Goniewicz Phd Pharmd of Roswell Park Cancer
The above story is provided based on materials by Roswell Park Cancer Institute. Note: Materials may be edited for content and length.
The consumption of more omega-6 fatty acids than omega-3 fatty acids is a well-known risk factor for a variety of health problems including cardiovascular disease cancer excessive inflammation and autoimmune diseases.
#Can celebrity cancer diagnoses prompt quitting smoking? Millions of people will make a resolution to quit smoking around Jan 1
celebrity cancer diagnoses. In a study published this week in Preventive medicine researchers from San diego State university the Santa fe Institute the University of North carolina
when celebrities publicly discuss their struggles with cancer diagnoses the resulting media coverage prompts more smokers to search for information on quitting than events like New year's day or World No Tobacco Day.
Public health experts have known long these discussions spur others to get screened for cancer or consider the same treatments
whether these discussions also promoted cancer prevention behaviors like quitting smoking. This question has evaded study
because the method most commonly used to assess cancer-related behaviors--annual telephone surveys--isn't fine-grained enough to tell researchers which events are influencing respondents'answers.
Using the case of former Brazilian President Lula da Silva who was diagnosed with laryngeal cancer in October 2011
and attributed his cancer to his long-held smoking habit the researchers analyzed both media coverage of smoking cessation
Lula's announced cancer diagnosis though tragic was potentially the greatest smoking cessation-promoting event in Brazilian history Ayers said.
Not only will quitting prevent throat cancer but it can prevent nearly all cancers including lung stomach breast etc.
The benefits don't end there. Following Lula's diagnosis Brazilian legislators passed a number of new laws strengthening anti-tobacco measures in the country making Brazil the largest smoke-free nation in the world said Joanna E
This study is the first to demonstrate that celebrity diagnoses can prompt the public to engage in behaviors that prevent cancer said Seth M. Noar coauthor and health communication professor at the University of North carolina at Chapel hill.
when the public is more receptive to messages about cancer than is ordinarily the case.
and cancer prevention advocates should better leverage these opportunities to promote behaviors that will prevent all future cancers.
Relevance in the timber industry and cancer researchpodocarpaceae constitute the second-largest conifer family. They grow mainly in mountainous regions in the Southern hemisphere.
Certain substances in their leaves moreover are playing an increasingly important role in cancer research.
and Frank J. Chaloupka of theuniversity of Illinois at Chicago and Geoffrey T. Fong of the University of Waterloo and the Ontario Institute for Cancer Research in Canada--assert that the model used by the FDA significantly underestimated the actual impact
#Link between allergies, increased risk of blood cancers in womena team of scientists looking into the interplay of the immune system and cancer have found a link between a history of airborne allergies--in particular to plants grass and trees
--with risk of blood cancers in women. Notably the study did not find the same association in men which suggests a possible gender-specific role in chronic stimulation of the immune system that may lead to the development of hematologic cancers.
The findings are published online ahead of the December print issue of the American Journal of Hematology.
and hematologic malignancies wrote first author Mazyar Shadman M d. M p h. a senior fellow in the Clinical Research Division at Fred Hutchinson Cancer Research center.
According to Shadman who led the research the immune system's potential role in cancer causation is a focus of intense scientific interest.
health history and cancer risk factors medication and supplement use and diet. Participants provided information on age race/ethnicity education smoking diet (fruit
Of the 79300 VITAL participants who filled out the questionnaires more than 66000 individuals were selected after eliminating those who had a prior history of malignancies other than non-melanoma skin cancers and missing information on baseline cancer history.
Participants were followed for a median of eight years until they withdrew from the study moved away had a cancer diagnosis other than hematologic malignancy
or non-melanoma skin cancer or died. Incidence of hematologic malignancies and other cancers was identified via the Surveillance Epidemiology and End Results (SEER) cancer registry of western Washington.
Of the participants 681 developed a hematologic malignancy during the follow-up period. These participants were more likely to be male to have two
When stratified by gender the incidence of blood cancers in response to these allergens was increased in women but not in men.
But none of the allergy medications are known to cause cancer Shadman said. The authors cite the study's strengths as its large population size the comprehensive baseline data regarding cancer risk
and medical conditions its prospective design and its use of the SEER registry an award-winning cancer registry program based at Fred Hutch.
Meanwhile the authors acknowledge the study's limitations namely the reliance on self-reporting of allergies the limitation of soliciting answers about current allergies only and particularly the limited number of hematologic cancers for each subset of allergy types.
Given the limited number of cases within each subtype of hematologic cancer the risk estimates need to be interpreted with caution
#and the possibility of chance finding due to multiple testing should be recognized Shadman and colleagues wrote.
The above story is provided based on materials by Fred Hutchinson Cancer Research center. Note: Materials may be edited for content and length.
#Research finds combo of plant nutrients kills breast cancer cellsa study led by Madhwa Raj Phd Research Professor in Obstetrics
and Gynecology at LSU Health Sciences Center New orleans and its Stanley S. Scott Cancer Center has found that a super cocktail of six natural compounds in vegetables fruits spices
and plant roots killed 100%of sample breast cancer cells without toxic side effects on normal cells.
The results which also revealed potential treatment target genes are published in the November 2013 issue of The Journal of Cancer.
One of the primary causes of both the recurrence of breast cancer and deaths is a small group of cancer stem cells that evade therapy notes Dr. Raj.
so it is critically important to develop new approaches to more effective and safer treatment or prevention of breast cancer.
The researchers administered these six at bioavailable levels to both breast cancer and control cells. They tested the compounds individually and in combination.
When combined though the super cocktail suppressed breast cancer cell growth by more than 80%inhibited migration
and triggered the process leading to cell death resulting in the death of 100%of the breast cancer cells in the sample.
According to the National Cancer Institute's SEER Program which includes data from LSU Health Sciences Center New orleans breast cancer is the second most common cancer with 232340 new cases estimated this year
There are an estimated 2829041 women currently living with breast cancer in the United states. Story Source: The above story is provided based on materials by Louisiana State university Health Sciences Center.
study suggestsin the largest study of its kind people who ate a daily handful of nuts were 20 percent less likely to die from any cause over a 30-year period than were those who didn't consume nuts say scientists from Dana-Farber Cancer
The most obvious benefit was a reduction of 29 percent in deaths from heart disease--the major killer of people in America said Charles S. Fuchs MD MPH director of the Gastrointestinal Cancer Center
But we also saw a significant reduction--11 percent--in the risk of dying from cancer added Fuchs who is affiliated also with the Channing Division of Network Medicine at Brigham
and a lower risk of diseases such as heart disease type 2 diabetes colon cancer gallstones and diverticulitis.
The above story is provided based on materials by Dana-Farber Cancer Institute. Note: Materials may be edited for content and length.
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011