There are indeed examples of H3n2 that we need to be concerned about says Sasisekharan who is also a member of MIT's Koch Institute for Integrative Cancer Research.
On surveillance in the war against cancerpredicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach
when it comes to the most deadly types of breast cancer. We know that one function of our immune system is to detect
and destroy pre-malignant cells before they can become cancer said lead author Lance D. Miller Ph d. associate professor of cancer biology at Wake Forest Baptist.
and from that information we can make predictions about cancer outcomes Miller said. The study published online ahead of print last month in the journal Genome Biology.
They found that in certain aggressive types of breast cancer such as basal-like or triple negative disease these immune signatures were highly predictive of cancer recurrence years after initial treatment.
Strikingly the patients who seemed to benefit the most were those with highly proliferative and clinically aggressive disease Miller said.
while low immune gene expression predicted for a high likelihood of cancer recurrence. An important next step Miller said will be translating this into a diagnostic test that may help doctors make more informed treatment decisions.
For doctors like Bayard Powell M d. chief of hematology and oncology at Wake Forest Baptist's Comprehensive Cancer Center new drugs designed to enhance anti-tumor immune responses are beginning to play a major
role in the treatment of certain forms of cancer. At Wake Forest Baptist we are now fighting cancer with state-of-the-art therapies including immunotherapeutics Powell said.
How a tumor's immunogenic disposition influences the effectiveness of immunotherapeutic drugs is an important question that could lead to valuable new strategies in personalized medicine.
and soy foods may be more effective in preventing prostate cancer when they are eaten together than
In our study we used mice that were engineered genetically to develop an aggressive form of prostate cancer.
Eating tomato soy and the combination all significantly reduced prostate cancer incidence. But the combination gave us the best results.
Prostate cancer is the most frequently diagnosed cancer in men but the disease has nearly a 100 percent survival rate
In older men it is often a slow-growing cancer and these men often choose watchful waiting over radiation
In countries where soy is eaten regularly prostate cancer occurs at significantly lower levels Erdman noted.
and one to two servings of soy foods daily could protect against prostate cancer Zuniga said.
When you eat whole foods you expose yourself to the entire array of cancer-fighting bioactive components in these foods Erdman said.
although low in genistein was still very effective at reducing cancer incidence. Story Source: The above story is provided based on materials by University of Illinois College of Agricultural Consumer and Environmental sciences (ACES.
This information is relevant to our efforts to improve muscle fitness in many health conditions such as aging cancer and heart failure.
Some studies have shown that trained dogs can detect cancerous tumours such as lung cancer by smelling a person's breath.
and prostate cancers and low levels can cause skin lesions diarrhea and other symptoms. The risks of arsenic in rice were highlighted recently in the national press
Funding for the study was provided by a PUSH grant from the Wake Forest Baptist Comprehensive Cancer Center
However in 2004 researchers contrary to popular assumptions revealed that isoprene was involved likely in the production of particulate matter tiny particles that can get lodged in lungs lead to lung cancer and asthma and damage other tissues not to mention the environment.
and reduces the risk of many common diseases including cancer cardiovascular disease depression and diabetes. The study to be presented consisted of 30 healthy adults who were randomized to take capsules containing 2000 International Units (IU) of vitamin D2 2000 IU of vitamin D3
The findings are published in Cancer Epidemiology Biomarkers & Prevention a journal of the American Association for Cancer Research.
If you are smoking from a hookah daily you are likely to be increased at risk for cancer.
and can cause lung cancer. Intake of nicotine the addictive component of tobacco was less with water pipe use.
and treat cancer. In diagnosing cancer nanoparticles with cancer-seeking properties might be injected into a patient before a medical scan.
If even an early form of cancer were present the particles would accumulate in the abnormal tissue
and make it visible for early diagnosis and the best chances for recovery. For treating the disease nanoparticles would preferentially collect in
and destroy only the abnormal cells sparing healthy tissue from the damage that triggers side effects with existing cancer chemotherapy.
and embryonic stem cells as well as cancer stem cells. As stem cell-based treatments continue to develop the authors say it will be increasingly important to understand the role of autophagy in preserving stem cells'health
what's currently known about the process in hematopoietic neural cancer cardiac and mesenchymal (bone and connective tissue) stem cells.
The team is also looking at the role of autophagy in breast cancer stem cells because of intriguing findings about the impact of FIP200 deletion on the activity of the p53 tumor suppressor gene
which is important in breast and other types of cancer. In addition they will study the importance of p53 and p62 another key protein component for autophagy to neural stem cell self-renewal and differentiation in relation to FIP200.
Among adolescents active smoking has been associated with increased asthma risk reduced lung function and growth early atherosclerotic lesions and increased cancer risk as well as premature mortality in adulthood.
or CTCS that break away from cancers and enter the blood often leading to the spread of cancer to other parts of the body.
If more studies confirm the technology's effectiveness the Nanovelcro Chip device could enable doctors to access
and identify cancerous cells in the bloodstream which would provide the diagnostic information needed to create individually tailored treatments for patients with prostate cancer.
Biopsies are extremely difficult in metastatic prostate cancer because the disease often spreads to bone where the availability of the tissue is low.
The biggest challenges in the treatment of cancer are that every person's tumor differs greatly
and their invasiveness in a tissue culture dish doctors may be able to quickly adjust their treatment plans in response We are optimistic that the use of our Nanovelcro CTC technology will revolutionize prostate cancer treatment.
We know that cancers evolve over time and that every patient's cancer is a unique problem--the'one-size-fits-all'approach is not going to allow us to cure prostate cancer
or any other cancer said Edwin M. Posadas MD medical director of the Urologic Oncology Program at Cedars-Sinai's Samuel Oschin Comprehensive Cancer Institute and senior author
of the article in the March online issue of Advanced Materials. This evolution means that we need to be able to monitor these changes over time
The existence of CTCS and their role in cancer metastasis was suspected first more than 140 years ago
the Nanovelcro CTC chip laser capture microdissection and whole exome sequencing said Yi-Tsung Lu MD a postdoctoral scientist at the Cedars-Sinai Samuel Oschin Comprehensive Cancer
This advancement will in principle allow us to track the genomic evolution of prostate cancer after we initiate a therapy
and will allow us to better understand the mechanism of drug resistance that is common in prostate cancer patients.
We hope the comprehensive understanding of cancer biology at the individual level will ultimately lead to better therapy choice for patients suffering from advanced cancer.
and may help doctors personalize therapies to a patient's unique cancer. To date CTC capture technologies have been able to do little more than count the number of CTCS which is informative but not very useful from a treatment planning perspective.
His enthusiasm is echoed by Leland W. K. Chung Phd director of the Urologic Oncology Research Program at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute.
Researchers from the Chinese Academy of Science Jonsson Comprehensive Cancer Center at UCLA and VA Greater Los angeles Healthcare System Beijing Genomics Institute in China Cytolumina Technologies
Cedars-Sinai researchers were supported by a Young Investigator Award and a Challenge Award from the Prostate Cancer Foundation research grants (P01 CA098912 and R01 CA122602) from the National institutes of health a Department of defense Idea
UCLA researchers were supported by a Creativity Award from the Prostate Cancer Foundation and research grants (R21 CA151159 and R33 CA157396) from the National institutes of health/National Cancer Institute Innovative Molecular Analysis
#Cancer biologists find DNA-damaging toxins in common plant-based foodsin a laboratory study pairing food chemistry
and cancer biology scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells.
and green teas and coffee activated the highest levels of a well-known cancer-linked gene called p53.
Funding for the study was provided by the National institutes of health's National Cancer Institute (CA62924) and the Everett and Marjorie Kovler Professorship in Pancreas Cancer Research.
Although there are medications that can compensate for the loss of female sex hormone production the drugs are recommended often not for long-term use due to the increased risk of heart disease and breast cancer.
and radiation treatments for certain types of cancer and menopause. The effects of hormone loss can range from hot flashes and vaginal dryness to infertility and increased risk of osteoporosis and heart disease.
We know that some people are much more vulnerable to alcoholism than others just like some people have a vulnerability to cancer
#Higher soy intake prior to lung cancer diagnosis linked to longer survival in womensummary of a study being published online March 25 2013 in the Journal of Clinical Oncology reports that Chinese women who consumed more soy before being diagnosed with lung cancer
New results from a large observational follow-up study conducted in Shanghai China indicate that women with lung cancer who consumed more soy food prior to their cancer diagnosis lived longer than those who consumed less soy.
The study published March 25 in the Journal of Clinical Oncology provides the first scientific evidence that soy intake has a favorable effect on lung cancer survival.
To our knowledge this is the first study to suggest an association between high soy consumption before a lung cancer diagnosis
Lung cancer is the leading cause of cancer-related death among women worldwide with only one in seven patients surviving for five years after diagnosis. Emerging evidence suggests that female hormones particularly estrogens
may affect lung cancer outcomes. Soy contains isoflavones estrogen-like substances that are known also to affect molecular pathways involved in tumor development and growth.
A recent study by the same research team showed that high intake of soy food was associated with a 40 percent decrease in lung cancer risk.
This new study assessed the impact of soy intake on lung cancer survival among participants of the Shanghai Women's Health Study which tracked cancer incidence in 74941 Shanghai women.
During the course of the study 444 women were diagnosed with lung cancer. The median time between the first dietary assessment and cancer diagnosis was 5 8 years.
In this analysis patients were divided into three groups according to soy food intake prior to lung cancer diagnosis. The highest and lowest intake levels were equivalent to approximately 4 oz or more and 2 oz or less tofu
per day respectively. Patients with the highest soy food intake had markedly better overall survival compared with those with the lowest intake 60 percent of patients in the highest intake group and 50 percent in the lowest intake group were alive
The findings may not necessarily apply beyond this study's population which has a very low prevalence of cigarette smoking a known risk factor for the development of lung cancer
and postmenopausal hormone replacement therapy use a factor that may negatively affect lung cancer prognosis. In addition the overall soy food intake is higher in Chinese women than in Western women.
whether consumption of soy food after diagnosis of lung cancer affects survival particularly among patients with early-stage disease who may benefit most from a nutritional intervention.
This research was supported by the U s. National Cancer Institute and conducted by investigators at Vanderbilt University in collaboration with those from the Shanghai Cancer Institute and NCI.
Story Source: The above story is provided based on materials by American Society of Clinical Oncology (ASCO.
I had a number of people--mainly women from my breast cancer weight loss study--say how inexpensive a Mediterranean-style diet was approached so
#Toxicity map of brain may help protect cognition for cancer patientsnew research from Wake Forest Baptist Medical center is giving radiation oncologists who treat brain tumors a better understanding of how to preserve the brain's functions while still killing cancer.
Radiation treatment of organs with cancer is designed to give enough of a dose to be toxic to the cancer tumor with minimal impact to the surrounding tissue
While avoiding normal tissue death is important it doesn't necessarily help prevent the cognitive and functional problems associated with cancer treatments.
In one of those trials 57 brain cancer survivors returned six months or more after their radiation treatment to determine
Advances in cancer treatment have increased survivorship rates and the length of time individuals are able to live following treatment Peiffer said
#Strong anticancer properties discovered in soybeansproteins found in soybeans could inhibit the growth of colon liver and lung cancers.
The study looked at the role soybeans could have in the prevention of cancer. Using a variety of soybean lines
The study showed that peptides derived from soybean meal significantly inhibited cell growth by 73%for colon cancer 70%for liver cancer
and 68%for lung cancer cells using human cell lines. This shows that the selected high oleic acid soybean lines could have a potential nutraceutical affect in helping to reduce the growth of several types of cancer cells.
and colon cancer diabetes asthma and other disorders. The immune system normally triggers an inflammatory response to an acute event such as injury or infection
's Jonsson Comprehensive Cancer Center and senior associate dean for research at the Geffen School of medicine.
what is believed to be a first of its kind study a research member at The Cancer Institute of New jersey
The Cancer Institute of New jersey is a Center of Excellence of the University of Medicine and Dentistry of New jersey-Robert Wood Johnson Medical school.
which is supported by The Cancer Institute of New jersey the UMDNJ-School of Public health and the UMDNJ-Robert Wood Johnson Medical school and provides help on quitting tobacco use through treatment education research and advocacy.
but there is more to the story according to Michael Steinberg MD MPH FACP a member of The Cancer Institute of New jersey
In fact smokers who relight cigarettes may be at higher risk of lung cancer and chronic bronchitis. That is something of which policy makers need to be aware he notes.
The study is supported by pilot funding through The Cancer Institute of New jersey. Story Source: The above story is provided based on materials by Cancer Institute of New jersey.
Note: Materials may be edited for content and length h
#Catastrophic loss of Cambodias tropical flooded grasslandsaround half of Cambodia's tropical flooded grasslands have been lost in just 10 years according to new research from the University of East Anglia.
#For smokers, low levels of Vitamin d may lead to cancernew research appearing online today in Clinical Chemistry the journal of AACC shows that decreased levels of Vitamin d may predispose smokers to developing tobacco-related cancer.
It is the primary causal factor for at least 30%of all cancer deaths and can lead to multiple kinds of cancer including bladder cervical esophageal head and neck kidney liver lung pancreatic and stomach as well as myeloid leukemia.
According to the Centers for Disease Control and Prevention the healthcare expenditures and productivity losses due to smoking cost the economy approximately $193 billion per year.
Researchers then followed the study participants for up to 28 years through the Danish Cancer Registry.
Of the participants 1081 eventually developed a tobacco-related cancer. The authors determined that the median Vitamin d concentration among these participants was only 14.8 ng/ml
These results show for the first time that the risk of tobacco-related cancers as a group is associated with lower concentrations of Vitamin d.
If further research confirms this it would be consistent with previous studies demonstrating the anti-tumorigenic effects of Vitamin d derivatives as well as the correlation of Vitamin d deficiency with favorable cancer-forming conditions and increased susceptibility to tobacco smoke carcinogens.
Interestingly though low Vitamin d levels were connected not with risk of other cancer types. Our analyses show that the association between lower concentrations of plasma Vitamin d
and higher risk of cancer may be driven by tobacco-related cancer as a group which has not been shown before stated author Børge G. Nordestgaard MD DMSC in the paper.
This is important for future studies investigating the association between plasma Vitamin d and risk of cancer.
#High-fat dairy products linked to poorer breast cancer survivalpatients who consume high-fat dairy products following breast cancer diagnosis increase their chances of dying from the disease years later according to a study by Kaiser permanente researchers.
The study published in the Journal of the National Cancer Institute is the first to examine the relationship between high-fat and low-fat dairy consumption following a diagnosis of breast cancer and long-term breast cancer survival.
Previous studies have shown that higher lifetime exposure to estrogen is a causal pathway to breast cancer.
The researchers studied a cohort of women who were diagnosed with early-stage invasive breast cancer between 1997 and 2000 primarily from Kaiser permanente's Northern California region (83 percent) and the Utah Cancer Registry (12 percent.
Those consuming larger amounts of high-fat dairy (one serving or more per day) had higher breast cancer mortality as well as higher all-cause mortality
and higher non-breast cancer mortality wrote lead author Candyce H. Kroenke Scd MPH staff scientist with the Kaiser permanente Division of Research
and a 49 percent increased risk of dying from their breast cancer during the follow-up period said Kroenke.
The study found an association between high-fat dairy and breast cancer mortality but no association with low-fat dairy products and breast cancer outcomes.
Women entered into the cohort approximately two years after their breast cancer diagnosis. At the beginning of the study 1893 women completed a self-administered food-frequency questionnaire
Of the total sample 349 women had a recurrence of breast cancer and 372 died of any cause 189 (50.8 percent) of them from breast cancer.
This research was part of the Life After Cancer Epidemiology (LACE) study one of several efforts by investigators with the Kaiser permanente Division of Research to consider the role of lifestyle factors such as nutrition exercise
and social support on long-term breast cancer survival and recurrence. While hundreds of studies have examined the role of lifestyle factors in cancer risk
and prevention this study is one of a small but growing number that focus on the role of lifestyle factors after a breast cancer diagnosis For example the Pathways study of breast cancer survivorship based at the Division of Research is collecting
and analyzing data about women's genetic background tumor characteristics and lifestyle choices immediately after diagnosis. Findings from this study along with the LACE study are providing objective information to help guide women as they make decisions following a breast cancer diagnosis;
among these findings are that soy decreases the risk of breast cancer recurrence quality of life after diagnosis influences outcomes
and physical activity is beneficial. Susan E. Kutner MD chair of the Kaiser permanente Northern California Regional Breast Care Task force said that the new study bolsters the counseling that Kaiser permanente gives breast cancer survivors about the importance of a low-fat diet as well as exercise
and weight management in preventing recurrence of the disease. Women have been clamoring for this type of information Dr. Kutner said.
They're asking us'Tell me what I should eat?''With this information we can be more specific about recommending low-fat dairy products.
The National Cancer Institute of the National institutes of health funded this study (grant R01ca129059. Story Source: The above story is provided based on materials by Kaiser permanente. Note:
However a 2001 National Cancer Institute (NCI) report found that smokers compensate for the lower smoke yield in light cigarettes
#Bitter melon juice prevents pancreatic cancer in mouse modelsa University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose
Three years ago researchers showed the effect of bitter melon extract on breast cancer cells only in a Petri dish.
and kill pancreatic cancer cells says Rajesh Agarwal Phd co-program leader of Cancer Prevention and Control at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical
Diabetes tends to presage pancreatic cancer and bitter melon has been shown to effect TYPE II-DIABETES diabetes and has been used for centuries against diabetes in the folk medicines of China and India.
and directly explored the link between bitter melon and pancreatic cancer. The result Agarwal says is Alteration in metabolic events in pancreatic cancer cells
and an activation of the AMP-activated protein kinase an enzyme that indicates low energy levels in the cells.
After studies in cell cultures the group showed that mouse models of pancreatic cancer that were fed bitter melon juice were 60 percent less likely to develop the disease than controls.
The Agarwal Lab is now applying for grants that will allow them to move the study of bitter melon into further chemoprevention trials in mouse models of pancreatic cancer.
and who were enrolled already in the Flight attendant Medical Research Institute (FAMRI)- International Early Lung cancer Action Program CT screening program from 2005-2012.
By using this imaging/approach people who have been exposed to tobacco smoke can be evaluated for lung cancer emphysema
Cancer Society and the Institute of Global Tobacco Control at Johns hopkins university. Meeting attendees were warned by speaker after speaker that
This research group has published previously work showing the benefits of GSSE in combating obesity heart dysfunction brain lipotoxicity and kidney cancer.
A University of Colorado Cancer Center review published in this month's issue of the journal Current Opinion in Gastroenterology shows that resistant starch also helps the body resist colorectal cancer through mechanisms including killing pre-cancerous cells
and reducing inflammation that can otherwise promote cancer. Resistant starch is found in peas beans
But consumed correctly it appears to kill pre-cancerous cells in the bowel says Janine Higgins Phd CU Cancer Center investigator and associate professor of Pediatrics at the University of Colorado School of medicine.
and sizes of lesions due to colorectal cancer and an increased number of cells that express the protein IL-10 which acts to regulate the body's inflammatory response Resistant starch may also have implications for the prevention
of breast cancer Higgins says. For example if you let rats get obese get them to lose the weight
This effect on obesity may help to reduce breast cancer risk as well as having implications for the treatment of colorectal cancer.
There are a lot of things that feed into the same model of resistant starch as a cancer-protective agent Higgins says.
which benefits exactly will pan out as mechanisms of cancer prevention one thing is clear: resistant starch should be on the menu.
and were successful in doing So long-term smokeless tobacco use is associated with cardiovascular disease and cancer.
The study was funded by the National Cancer Institute (R01 CA121165. Story Source: The above story is provided based on materials by Mayo Clinic.
#Researchers find potential new therapeutic target for treating non-small cell lung cancerresearchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer.
IKBKE overexpression has been associated with breast and prostate cancers. However it had not been linked to environmental carcinogen such as tobacco smoke until now.
Tobacco smoke is documented the strongest initiator and promoter of lung cancer. The traditional model holds that tobacco components promote carcinogenesis through a process that leads to DNA damage.
Recent studies have shown that tobacco smoke can also promote lung cancer through changes in the pathways that regulate cell proliferation and survival.
in order to find potential drug targets to treat non-small cell lung cancer. In this study IKBKE was found to be induced by two tobacco carcinogens:
Their findings suggest that IKBKE is a key molecule related to tobacco-induced lung cancer. Since IKBKE kinase is induced by tobacco small molecular inhibitors of IKBKE could have a therapeutic drug potential for lung cancer explained lead author Jin Q. Cheng Ph d. M d. senior member
of the Molecular Oncology Department at Moffitt. Current treatments for non-small cell lung cancer include surgery radiotherapy and chemotherapy.
However patients eventually develop resistance to treatment. There is a great need to better understand the molecular mechanism of resistance
According to the researchers STAT3 is activated frequently in various types of human cancers and when activated STAT3 increases IKBKE overexpression and protein levels.
In non-small cell lung cancer nicotine-induced IKBKE depends on STAT3. The authors noted that the activation stage of STAT3 represents an attractive therapeutic potential
and IKBKE levels increase in response to nicotine and nicotine-derived nitrosamine ketone this evidence can be used potentially to develop a non-small cell lung cancer intervention strategy that targets IKBKE concluded Cheng.
The work was supported by National Cancer Institute Grants CA137041 and P50 CA119997 and James & Esther King Biomedical Research Program 1kg02 1kd04 and 1kn08.
The above story is provided based on materials by H. Lee Moffitt Cancer Center & Research Institute.
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