| Glioma (2) |  |
| Melanoma (7) | |
| Tumor (11) | |
#A new way to model cancer Sequencing the genomes of tumor cells has revealed thousands of mutations associated with cancer.
In a study appearing in the Aug 6 issue of Nature the researchers generated liver tumors in adult mice by disrupting the tumor suppressor genes p53 and pten.
The sequencing of human tumors has revealed hundreds of oncogenes and tumor suppressor genes in different combinations.
and pten the researchers were able to disrupt those two genes in about 3 percent of liver cells enough to produce liver tumors within three months.
Using CRISPR to generate tumors should allow scientists to more rapidly study how different genetic mutations interact to produce cancers as well as the effects of potential drugs on tumors with a specific genetic profile.
Enhanced potential of this powerful technology will be realized with improved delivery methods the testing of#CRISPR/Cas9 efficiency in other organs and tissues and the use of CRISPR/Cas9 in tumor-prone backgrounds.
The nanoparticles deliver genes for an enzyme that converts a prodrug called ganciclovir into a glioma cell killer.
There is no reliable treatment for glioma which has a 5-year survival rate of 12 percent.
The method therefore opens up the prospect of detecting tumors that are less than 1mm in diameter in an early stage of growth before they spread through the body
"The team tested the therapeutic potential of the nanoparticles by loading them with an anti-melanoma drug
In further experiments, the researchers found they could alter the infusion of the particles into melanoma cells by adjusting the polymer coatings.
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
"This is a versatile platform to carry a multitude of drugs-for melanoma, for other kinds of cancers and for other diseases,"says Rohit Bhargava."
The team of researchers tested the therapeutic potential of these carbon nanoparticles by loading them with an anti-melanoma drug
Scientists also found that they can alter the infusion of the particles into melanoma cells by adjusting the polymer coatings.
It is a very versatile platform to treat melanoma, other kinds of cancers and other diseases.
< Back - Next >
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011