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#A new way to model cancer Sequencing the genomes of tumor cells has revealed thousands of mutations associated with cancer.
In a study appearing in the Aug 6 issue of Nature the researchers generated liver tumors in adult mice by disrupting the tumor suppressor genes p53 and pten.
The sequencing of human tumors has revealed hundreds of oncogenes and tumor suppressor genes in different combinations.
and pten the researchers were able to disrupt those two genes in about 3 percent of liver cells enough to produce liver tumors within three months.
Using CRISPR to generate tumors should allow scientists to more rapidly study how different genetic mutations interact to produce cancers as well as the effects of potential drugs on tumors with a specific genetic profile.
Enhanced potential of this powerful technology will be realized with improved delivery methods the testing of#CRISPR/Cas9 efficiency in other organs and tissues and the use of CRISPR/Cas9 in tumor-prone backgrounds.
The method therefore opens up the prospect of detecting tumors that are less than 1mm in diameter in an early stage of growth before they spread through the body
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
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