#Rate of investment in medical research has declined in U s. increased globally From 2004 to 2012,
the rate of investment in medical research in the U s. declined, while there has been an increase in research investment globally, particularly in Asia, according to a study in the January 13 issue of JAMA.
For the last century medical research including public health advances has been the primary source of and an essential contributor to improvement in the health and longevity of individuals and populations in developed countries.
Few previous analyses have compared medical research in the United states with other developed countries according to background information in the article.
and who supports medical research as well as resulting patents publications and new drug and device approvals.
The share of U s. medical research funding from industry accounted for 46 percent in 1994
medicines currently in clinical trials. Underfunding of service innovation Health services research (which examines access to care the quality
in comparison with total medical research funding. Private insurers ranked last (0. 04 percent of revenue) and health systems 19th (0. 1 percent of revenue) among 22 industries in their investment in innovation.
The analysis underscores the need for the United states to find new sources to support medical research
and creates an environment that enables innovation write Victor J. Dzau M d. of the Institute of Medicine Washington D c. and Harvey V. Fineberg M d. Ph d. of the University of California San francisco in an accompanying editorial.
and professor and chairman of the Department of Neurological Surgery at University of Washington Medicine and co-chair of the Head Neck and Spine Committee of the National Football league.
"These include materials science, electronics, neuroscience, medicine, and algorithm programming. I don't think there are many places in the world where one finds the level of interdisciplinary cooperation that exists in our Center for Neuroprosthetics."
"The standard way we do electrocardiograms does not provide sufficient information to enable medical professionals to focus in clearly to the area of concern."
since medical staff can identify and isolate confirmed Ebola cases more rapidly, "said Dr. Christiane Stahl-Hennig, the Head of the Unit of Infection Models."
The medical potential of this pathway warrants detailed study to provide information about the pathway's enzymes and their regulation.
I. Shulman the George R. Cowgill professor of medicine and cellular & molecular physiology--developed a novel method to measure the rate of triglyceride production from fatty acids in three types of animals:
when we can use ipscs for human therapy aren't that far away says Zhaohui Ye Ph d. an instructor of medicine at the Johns hopkins university School of medicine.
Linzhao Cheng Ph d. a professor of medicine and oncology in the Johns hopkins university School of medicine; and their colleagues pitted CRISPR against TALEN in human ipscs adult cells reprogrammed to act like embryonic stem cells.
"explains senior author Evan Rosen, MD, Phd, of the Division of Endocrinology, Diabetes and Metabolism at BIDMC and Professor of Medicine at Harvard Medical school."
#Byproducts from bacteria awaken dormant T-cells HIV viruses Dental and medical researchers from Case Western Reserve University found another reason to treat periodontal disease as soon as possible.
The emergence of antibiotic-resistant forms of S. aureus is a significant problem worldwide in clinical medicine.
Wong who is also Assistant professor at Harvard Medical school in the Departments of Biological Chemistry & Molecular Pharmacology and Pediatrics and Investigator at the Program in Cellular and Molecular Medicine at Boston Children's Hospital calls the new
In traditional preservation methods, donated tissues are stored within a medical-grade refrigeration unit in sealed bags filled with a standard preservation solution.
and medical director of the Missouri Orthopaedic Institute, said that patients with metal and plastic implants often are forced to give up many of the activities they previously enjoyed
and medicine,"says Schiller. With the help of chemical reactions that were previously impossible in the cell,
Medical research can take years to move from bench to bedside as can US Food and Drug Administration (FDA) approval.
"Going forward, Huang said there are numerous possibilities for the material to control elastic waves including super-resolution sensors, acoustic and medical hearing devices,
and funded by the Robert Wood Johnson Foundation--published online-first by the New england Journal of Medicine.
and parent study principal investigator, Karin V. Rhodes, MD, MS, director of the department of Emergency Medicine's Center for Emergency Care Policy and Research."
and prevention options for stress-related psychiatric and medical conditions and may shed light on the aging process itself. said Dr. Tyrka also the director of research for Butler Hospital l
Wake Forest School of medicine, an established leader in medical education and research; and Wake Forest Innovations,
"said principal investigator Eyal Raz, MD, professor of medicine.""The role of camp formation and action in dendritic cells in the induction of allergic response was added really surprising
co-author Paul Insel, MD, professor of pharmacology and medicine.""It suggested to us that this signaling pathway is involved in other immune-related functions."
professor of medicine and a member of the Veteran's Affairs San diego Healthcare System, said"such molecules
Gas sensors or implantable chips for medical applications which can gather information about blood sugar levels
. and is now a consulting professor of medicine at Stanford began curating a registry of twins for research purposes.
and medical director of the Stanford-Lucile Packard Children's Hospital Vaccine Program. While many previous studies have suggested a powerful genetic component in vaccine responsiveness Davis noted that those studies typically were performed in very young children who had undergone not yet the decades of environmental exposure that appears to reshape the immune system over time.
Other Stanford co-authors of the study are Atul Butte MD Phd associate professor of pediatrics (systems medicine) and of genetics;
In developing regions where the economy is weak and medical services are limited, global health experts say as many as 200 million women want access to long-term,
The medical simulator includes two training models: a stand-alone replica arm and a layered band that can be worn by health workers who act as"patients"during practice sessions."
published in the journal Science Translational Medicine, is the first step in the use of programmable cells for medical diagnosis.
#Drug-induced tissue regeneration demonstrated by scientists A study led by Ellen Heber-Katz, Phd, of the Lankenau Institute for Medical Research (LIMR), part of Main line Health (MLH),
The study findings were reported in the June 3, 2015, issue of Science Translational Medicine, a peer-reviewed journal of the American Association for the Advancement of Science.
"This remarkable work has vast importance in medicine and surgery and spotlights the diverse and important scientific investigations underway at LIMR,"says George Prendergast, Phd, President and CEO of LIMR."
"This means the present method can be utilized as a prescreening test for point-of-care bacterial diagnosis for various applications including medicine and food hygiene.""
Schwab, an assistant professor at NYU Langone and its Skirball Institute of Biomolecular Medicine, says similar laboratory test plans are underway for more potent CXCR4 antagonists, most likely in combination with established chemotherapy regimens.
"said co-senior author Kumar Sharma, MD, a professor of medicine and director of the Center for Renal Translational Medicine at UC San diego School of medicine."
"Drawing on collaborative expertise in synthetic chemistry, molecular biology and translational medicine, the team has produced findings with significant potential to reduce inflammation, a critical driver of the devastating consequences of obesity-related diseases,
#Scientists find genetic variants key to understanding origins of ovarian cancer New research by an international team including Keck Medicine of USC scientists is bringing the origins of ovarian cancer into sharper focus.
'said Simon Gayther, Ph d.,professor in preventive medicine, Keck School of medicine of USC, corresponding author of the international genome-wide association study (GWAS).'
'Co-first author Kate Lawrenson, Ph d. of Keck Medicine of USC believes the research will lead the way to the development of risk prediction strategies followed by clinical interventions with the potential to prevent ovarian cancer altogether,
posters and guides for around 60 different activities. 1 To evaluate the Toolkit's effectiveness, researchers from the London School of Hygiene & Tropical Medicine,
Dr Karen Devries from the London School of Hygiene & Tropical Medicine, said:""What's notable about these results is that we found a very large reduction.
"The 24-hour ultra-marathon study, published in the International Journal of Sports Medicine and the multi-stage ultra-marathon study, published in Exercise Immunology Reviews,
and include medical diagnostics and fluorescence spectroscopy as well as UV curing and disinfection. A further application field is plant lighting, for
enabling in-situ measurements in various security and health relevant fields including biology, medicine, food control, and pharmacy.
Dr. Samuel Asfaha, a clinician-scientist at Lawson and an assistant professor of medicine at the Schulich School of medicine & Dentistry, Western University,
and will lead to new candidates for biological and medical applications, and new production routes for enzymes of industrial use."
The test and a potential treatment are based on an emerging discipline of medical research called epigenomics, the complex biological process through
Dr. Hesham Sadek, Assistant professor of Internal medicine and with the Hamon Center for Regenerative Science and Medicine.
or chemical environment to provide unique functionality in a wide range of applications from energy to medicine.
or proteins that could be targeted by drugs, eventually leading to new medicines to fight cancer r
In a study published in the journal Nature Medicine, the researchers reported that the tumor-suppressing protein AIM2,
This could be useful for medical servers, government data communications, financial markets and military communication channels, as well as quantum cloud communications and distributed quantum computing."
In addition, PLA is biocompatible and thus suitable for medical use, for instance in absorbable suture threads.
and the London School of Hygiene & Tropical Medicine identified a key protein, called a protein kinase,
& Tropical Medicine, said:""It is a great advantage in drug discovery research if you know the identity of the molecular target of a particular drug and the consequences of blocking its function.
Professor Patrick Maxwell, chair of the MRC's Molecular and Cellular Medicine Board, said:""Tackling malaria is a global challenge,
Their work, published online July 8 by the journal Science Translational Medicine, could pave the way for gene therapy in people with hearing loss caused by genetic mutations."
precision medicine treatment injected into their ears to restore hearing, "Holt says. Sound transducers: How TMC works Holt's team showed in 2013 that TMC1
and Medical Oncology at Jefferson. Metastasis is thought of as the last stage of cancer. The tumor undergoes a number of changes to its DNA--mutations--that make the cells more mobile
As a result, patients often suffer for months before finding a medicine that makes them feel better.
who is also the vice president for Medical Affairs, University of Maryland, and the John Z. and Akiko K. Bowers Distinguished Professor and Dean of the School of medicine."
It represents one more important step in realizing the true promise of precision medicine in oncology--the main focus behind research at VHIO which aims to both advance
However, recent data from the research group led by Markus Hengstschläger of the Institute for Medical Genetics of the Medical University of Vienna now suggest that another protein complex,
The Journal of the American Medical Association, is the first to follow patients taking patiromer for more than a few weeks.
a huge deal,"said George Bakris, MD, professor of medicine and director of the Comprehensive Hypertension Center at the University of Chicago Medicine."
The findings"have the potential to fundamentally change the current treatment approach to hyperkalemia,"according to an accompanying editorial by nephrologist Wolfgang Winklemayer, MD, Scd, of Baylor College of Medicine.
"The results of a pilot clinical study, carried out at the Leeds Institute of Cardiovascular and Metabolic Medicine under the supervision of Professor Peter Grant,
Professor Grant, Professor of Medicine at the University of Leeds and Consultant diabetes specialist, said:"
Friedman and his research team at the Albert Einstein College of Medicine and University of California Los angeles explored the mechanisms by
The finding means metal foams hold promise for use in nuclear safety, space exploration and medical technology applications."
This is the result of a ground-breaking new technique developed by a group of researchers from the Faculty of health and Medical sciences at the University of Copenhagen.
"which means it is not responsive to the common medical therapeutics. BLBC is more likely to metastasize
"explained corresponding author Sam Thiagalingam, Phd, associate professor of genetics & genomics, medicine and pathology & laboratory medicine at BUSM.
The vote paves the way for a medical world first for Britain, but one that is fiercely disputed by some religious groups and other critics.
Fove could be used as a medical HMD where surgeons use it for detailed camera work
and is expected to live a life free of medical complications. Otherwise she would have required multiple surgeries during the first years of her life.
medical professionals are hoping to include 3d printers into their regular toolset i
#New high-speed 3-D microscope gives deeper view of living things Opening new doors for biomedical and neuroscience research, Elizabeth Hillman,
and Gregory Kato of the Department of Medicine at the University of Pittsburgh. People with sickle cell disease an inherited genetic disorder have a variant form of hemoglobin that causes their red blood cells to take on a characteristic sickle shape when in low-oxygen conditions.
Clenbuterol does not harm muscle tissue in rodents at those doses showing the lab-grown muscle was giving a truly human response. ne of our goals is to use this method to provide personalized medicine to patientssaid Bursac. e can take a biopsy from each patient grow many
professor of biomedical engineering medicine and nursing at Duke university. The research was supported by NIH Grants R01ar055226 and R01ar065873 from the National Institute of Arthritis and Musculoskeletal and Skin disease and UH2TR000505 from the NIH Common Fund for the Microphysiological Systems Initiative.
said Raymond obrowland, professor of diagnostic medicine and pathobiology at Kansas State College of Veterinary medicine. t really the future of diagnostics for both humans and animals.
including clinical medicine, food safety testing, environmental monitoring and biodefense o
#Nature Inspires First Artificial Molecular Pump Using nature for inspiration, a team of Northwestern University scientists is the first to develop an entirely artificial molecular pump, in
particularly neuropathic pain, said Akbar Panju, medical director of the Michael G. Degroote Institute for Pain Research and Care,
a clinician and professor of medicine. his research will help us understand the response of cells to different drugs and different stimulation responses,
or personalized medical therapy for patients suffering with neuropathic pain. ource: Mcmaster Universit i
#Controlling a robotic arm with a patient intentions Giving himself a drink for the first time in 10 years,
In a clinical trial, the Caltech team and colleagues from Keck Medicine of USC have implanted successfully just such a device in a patient with quadriplegia
the Caltech team collaborated with surgeons at Keck Medicine of USC and the rehabilitation team at Rancho Los Amigos National Rehabilitation Center.
We have created a unique environment that can seamlessly bring together rehabilitation, medicine, and science as exemplified in this study,
says Professor Geoff Woods from the Cambridge Institute for Medical Research at the University of Cambridge,
The researchers believe that the device has enormous potential for use in point-of-care medical diagnostics,
as a significant step toward advancing personalized medicine. The ability to accurately find mutations that are biomarkers for disease will help clinicians determine treatment paths for patients,
in Bristol School for Cellular and Molecular Medicine, and the study lead author, said: hile inflammation is critical to prevent infection,
The U s. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) are considering findings from the trial to make the treatments available to more patients with advanced melanoma.
More Researchthe Journal of Clinical Oncology report comes on the heels of Chesney findings from another study published this month in the New england Journal of Medicine.
a process common to delivery of many species in biology and medicine you could go to the doctor
or record neural activity. hese type of things have never been done before, from both a fundamental neuroscience and medical perspective,
The advance could mean a giant step forward in efforts to tailor medical treatment plans to individual patients.
the Ingalls Professor of Cancer Genetics at the university School of medicine and a medical oncologist at University Hospitals Case Medical center Seidman Cancer Center. e have developed a drug that acts like a vitamin for tissue stem cells,
Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field,
ranging from fundamental science to medicine. In astronomy, it will boost the performance of adaptive optics, a technology at the heart of the European Extremely Large telescope (E-ELT.
A summary of the research appears June 17 in Science Translational Medicine. s a neurosurgeon, I in agony when I taking out a tumor.
Dr Perriman from Bristol School of Cellular and Molecular Medicine said: rom our preliminary experiments, we found that we could produce these artificial membrane binding proteins
Heather and Melanie Muss Endowed Chair and a principal investigator in the UCSF Brain tumor Research center and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. t may be unwelcome
which could have broad medical applications, Borgens said. he technology is in the early stages of testing,
But bacteriophages can also cause potentially harmful side effects, according to James Collins, the Termeer Professor of Medical Engineering and Science in MIT Department of Biological engineering and Institute of Medical Engineering and Science,
and the new findings suggest that parasite calcineurin should be a focus for the development of new antimalarial drugs. ur study has great biological and medical significance, particularly in light of the huge disease burden of malaria,
current director of pipeline research of Emergent biosolutions. here are multiple filoviruses that threaten our communities, front line medical workers and defense personnel,
and a professor of radiology and of medicine at Weill Cornell Medical College. f physicians can accurately predict who is at risk,
Min said. t embodies the goal of precision medicine, namely, to precisely identify and exclude the patients who have
he continued. e have medicine that saves lives; we just need to identify earlier the right patients
but inside the clear chip lies the potential to improve how medicine and medical research is done. f you can integrate
and automate an analysis technique into a chip, it opens doors to great applications, said Janssen, a postdoctoral researcher in the Sumita Pennathur Lab at UC Santa barbara. With only a minimal amount of human plasma,
particularly in remote areas where people don have access to a full medical lab, as well as data gathering for clinical trials or epidemiological studies.
For the impact his project will have in the field of translational medicine, the postdoctoral scholar has been awarded the 2015 Lindros Award from the UCSB Translational Medical Research Laboratory (TMRL).
and methodologies in all of medicine, said Dr. Scott Hammond, executive director of TMRL. orking with the Pennathur Lab, Kjeld Janssen research is intended to bring real-time detection to the world of medicine.
This technology, said Hammond, allows for the identification of specific DNA markers in an advanced microfluidic device. urther,
or medicine necessary to monitor or treat patients. Efforts to study and combat highly infectious diseases,
#Gene therapy restores hearing in deaf mice Proof-of-principle study takes a step toward precision medicine for genetic hearing loss.
Their work, published online July 8 by the journal Science Translational Medicine, could pave the way for gene therapy in people with hearing loss caused by genetic mutations. ur gene therapy protocol is not yet ready for clinical trialse need to tweak it a bit moreut in the not-too-distant
precision medicine treatment injected into their ears to restore hearing, Holt says. Holt team showed in 2013 that TMC1
HMS professor of medicine and director of the Center for Virology and Vaccine Research at Beth Israel Deaconess. e are encouraged very by the results of this latest preclinical HIV-1 vaccine study
remote medicine and a wide variety of other business, civil and military uses. 3d Tau SSE technology is designed to be embedded directly into a new generation of screens for televisions, movie theaters, computer displays, game
a senior investigator at the Gladstone Institute of Cardiovascular disease and a professor of medical genetics and cellular and molecular pharmacology at UC San francisco. his technology could help us quickly screen for drugs likely to generate cardiac birth defects,
it requires medical personnel with technical skills and brings the risk of needle-related diseases and injuries.
It is also easy to use without the need for trained medical personnel, making it ideal for use in developing countries,
University of Illinois at Urbana-Champaign and a senior author. ltra-miniaturized devices like this have tremendous potential for science and medicine. ith a thickness of 80 micrometers and a width of 500 micrometers,
According to Joost Klaase, surgeon at the Medical Spectrum Twente (MST) and involved with the research, the medical world has need a for the system. he nomogram for risk of breast cancer recurrence gives us a tool to create a tailor-made follow-up for breast cancer patients:
Alden Chadwick via flickr. com, CC BY 2. 0. In order to help medical professionals combat this deadly affliction,
a researcher involved in the study. his type of sensing platform offers a large variety for medical diagnostics,
researchers are already hailing it as an important innovation in medical diagnoses. The sensor has shown yet its value in detecting cholera without error,
a Professor in the Faculty of medicine Department of Laboratory Medicine and Pathobiology. ee now discovered the DNA mbulanceand the road it takes. ekhail discovered this DNA ambulance,
#New technology helps personalized medicine by enabling epigenomic analysis with a mere 100 cells A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as
This epigenomic characterization potentially allows medical doctors to create personalized treatment of diseases by understanding the state of a patient,
which is a medical emergency potentially requiring surgical intervention, says Koch Institute research affiliate Giovanni Traverso,
a professor of medical science and engineering at Brown University who was not involved with this study. his is a very smart approach.
are an obvious candidate for medical applications of the technology, as these cells not only stand at the center of many disease processes,
and medicine. t been great to be part of this exciting collaboration, and I look forward to seeing the insights from this work used to help patients in the future,
The cells thus behaved in a similar manner than in the patient, offering attractive possibilities for translational medicine.
The results could have implications for medical research, said Babu. For example, n the human population you have many individuals that carry single nucleotide polymorphisms
such as in medical diagnostics for example. Their results are published in Nature Communications. Three-dimensional structures in materials and biological samples can be investigated using X-ray tomography,
space exploration and medical applications abound for low-density, nontoxic structural shielding materials Lightweight composite metal foams can absorb energy from impacts
The discovery means the materials could be useful in spacecraft, the nuclear industry and in medicine.
#White house unveils $215 million plan to develop patient-specific medical treatments The White house unveiled a"Precision Medicine Initiative"today a $215 million investment that will go toward building a database containing genetic information
"Most medical treatments have been designed for the verage patient, according to A white house statement. As a result, treatments can be very successful for some patients,
"The Precision Medicine Initiative will leverage advances in genomics, emerging methods for managing and analyzing large data sets while protecting privacy,
If that's the case, then precision medicine"will be useless, "as basic medicine is where all the ideas for how to use that information is produced.
Eisen also told The Verge that the money will be flushed down the toilet "if the databases developed through this initiate are constructed poorly."
"The potential for precision medicine to improve care and speed the development of new treatments has begun only just to be tapped,"according to the White house statement.
In a new study published today in Science Translational Medicine, researchers detail how sequencing genetic information in sperm can show
and in about 40 percent of these cases, the male partner is either the sole cause or partially contributing, according to the American Society for Reproductive Medicine.
"Sperm harbors a rich population of RNA (C. Bickel/Science Translational Medicine) Krawetz has suspected long that sperm RNA might play a role in infertility.
The European Medicines Agency (EMA) the regulatory group in the European union which roughly parallels the FDA gave a positive opinion of the vaccine,
This finding means it may soon be possible to harness these little machines to produce more complex proteins, perhaps one day for use in medicine.
The order points to implementations in medicine, climate science, and aerospace as just some of the early benefits of supercomputing power.
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