| Toxic (459) |  |
Using conventional weapons on such facilities runs the risk of spreading highly toxic substances, so the Pentagon has funded a number of
causing cells to release toxic gas and cilia to flap. If people have a genetic variant that produces a different form of this bitter receptor
Targeted biological therapy can reduce toxicity and improve outcomes for many cancer patients, when compared to the adverse effects of standard chemotherapeutic drugs.
whether a compound is toxic or carries other liabilities, or has the right mix of properties to become a safe and effective therapeutic agent,
They grew rat smooth muscle cells on their prototypes to determine that the materials were not toxic.
and their toxicity can cause kidney failure and other systemic damage. Professor Dolores Fregona and her research team at the University of Padua in Italy designed and tested gold compounds with the aim of elivering the metal as a cytotoxic smart bombkilling off cancer cells while minimising the impact on other organs.
and slowed their proliferation, without any discernible toxic impact on lungs, spleen, liver or kidney.
sometimes toxic and are not readily biodegradable, "says project coordinator Pietro Luigi Cavallotti. Although biodegradable synthetic oils have been developed,
there has never been need a greater for quick and accurate ways to detect explosives, toxic chemicals, illegal drugs and other potential hazards to public safety and health.
and it is 60 times more toxic. It needs a separate pre-treatment stage to transform it to the less toxic As V. As part of a European union (EU) funded research project, an innovative consortium in Greece,
backed by an EU grant of#833,842, has developed a new adsorbent media that can easily
"Our innovative Aquaszero granules now provide a cost-effective solution to easily remove all traces, even the highly toxic form of arsenic (As III."
and identifying toxic fumes in the air. Another area of application is medical surgery. A doctor could transfer data to
Rare liver toxicity is now the major safety concern with new drugs and can often be detected only after many thousands of patients have received treatment Watkins says.
and at worst are toxic, are thought to kill more than 700,000 people each year. While less than 1 percent of the US pharmaceuticals market is believed to be counterfeit,
when stores of toxic nerve agents need to be decommissioned. ftentimes, chemical agent stockpiles are decommissioned through processes that involve treatment with heat
a new immune system. 72-HOUR FAST Prolonged fasting also protected against toxicity in a pilot clinical trial in
and turn it into a mineral which prevents the toxic material from leaching into groundwater.
when exposed to extremely high and toxic concentrations of uranium levels that would destroy individual Geobacter cells the biofilms didn t just survive they thrived she adds.
and at worst are toxic are thought to kill more than 700000 people eachâ year. While less than 1 percent of the US pharmaceuticals market is believed to be counterfeit it is a huge problem in the developing world. ne challenge in fighting counterfeiting is need the to stay ahead of the counterfeiterssays Nicholas Kotov professor of chemical engineering who led the University
which uses no metals or toxic materials, for use in power plants, where it could make the energy grid more resilient and efficient by creating a large-scale way to store energy for use as needed. he batteries last for about 5,
While previous battery designs have used metals or toxic chemicals, Narayan and Prakash wanted to find an organic compound that could be dissolved in water.
traditional approaches see producers pay hefty fees to have hauled toxic wastewater off to treatment plants,
Reguera, along with lead authors and graduate students Allison Speers and Jenna Young, evolved Geobacter to withstand increasing amounts of toxic glycerol.
Together, the bacteria appetite for the toxic byproducts is inexhaustible. hey feast like theye at a Las vegas buffet
to form these inks was hydrazine##a highly toxic explosive liquid used in rocket fuel. Brutchey and David Webber of USC mixed two compounds to create the new solvent that effectively dissolves a class of semiconductors known as chalcogenides. hen the two compounds work together they do something quite remarkablesays Brutchey.
Those molecules are highly toxic unless properly controlled Britt notes. The cyanide and carbon monoxide groups were known to come from the amino acid tyrosine Britt says.
and studied could provide a scalable inexpensive platform to monitor toxic vapors from industrial solvents.
The new insight may be helpful in finding ways to minimize the potential toxicity of graphene says Agnes Kane chair of the pathology and laboratory medicine department at Brown and one of the study s authors.
If there some feature that is responsible for its toxicity then maybe the engineers can engineer it out.
Is nanotech toxic? Discovered about a decade ago graphene is a sheet of carbon just one atom thick.
and material scientists at Brown aimed at understanding the toxic potential of a wide variety of nanomaterials.
But Kane says this initial study provides an important start in understanding the potential for graphene toxicity.
The toxicity of the nanoparticles causes the macrophages to transform into foam cells or lipids leading to the development of lesions and hastening the onset of atherosclerosis.
In addition they can be used for drugs of high toxicity or a short half-life.##Both Choi and Kim are members of the Micro and Nano technology Laboratory at the U. of
Others have concerns about pollution or toxic residue from the conversion process. Blest tells us that,
polyethylene, polystyrene and polypropylene##PP, PE,#PS plastics), there is no toxic substance produced and any residue can be disposed of with regular burnable garbage.
According to the blurb,##the film details plastic s path over the last 100 years and provides a wealth of expert interviews on practical and cutting edge solutions to recycling, toxicity and biodegradability.##
(i e. get me the hell away from this toxic thing response), it dehumanizes the other person,
and a toxic substance and our reaction is deep disgust. But the uncanny valley is only the first step in
Sodium cyanide is highly toxic but vital for extracting metals such as gold from its ore. Currently sodium cyanide is transported to and from a site,
Clearly kitchenware will never be the same and without the potential toxicity of conventional nonstick surfaces.
but without that carrier's toxic side effects. Neil Barclay of the University of Oxford, UK, was part of the team that worked out the CD47 structure that inspired Discher s work2."
so boosting this will not be as toxic as chemotherapy, says Wafik El-Deiry, an oncologist at Pennsylvania State university in Hershey and lead author of the study,
although early clinical trials for TRAIL-based therapies showed little toxicity, they were not very successful at treating cancer,
A more immediate benefit of 3-D printing embryonic stem cells might be the ability to make tissue samples that could be used to accurately test drug compounds for toxicity in humans, without the need for animal testing, according to the researchers c
one of a class known as multidrug and toxic compound extrusion transporters (MATES) that are found in cell membranes.
which eight horses had developed suddenly hepatitis after being injected with an antitoxin to prevent them from developing botulism.
The researchers used next-generation sequencing to analyse RNA samples from the antitoxin and from two of the horses,
as well as in the animal (from a different farm) that was the source of the contaminated antitoxin.#"
the team inoculated four healthy horses with the contaminated antitoxin. Within ten weeks all of them carried TDAV in their bloodstream,
myobundles undergo dose-dependent hypertrophy or toxic myopathy similar to clinical outcomes. Human myobundles provide an enabling platform for predictive drug
#Molecular Inhibitor Breaks Cycle That Leads to Alzheimer's A molecular chaperone has been found to inhibit a key stage in the development of Alzheimer disease and break the toxic chain reaction that leads to the death of brain cells, a new study shows.
thereby helping to avoid the formation of highly toxic clusters that enable the condition to proliferate in the brain.
This step where fibrils made up of malfunctioning proteins assist in the formation of toxic clusters is considered to be one of the most critical stages in the development of Alzheimer in sufferers.
so we can prevent the toxic effects of protein aggregation that are associated with this terrible condition.
These oligomers are highly toxic to nerve cells and are thought now to be responsible for the devastating effects of Alzheimer disease.
This second stage, known as secondary nucleation, sets off a chain reaction which creates many more toxic oligomers
and ultimately amyloid fibrils, generating the toxic effects that eventually manifest themselves as Alzheimer. Without the secondary nucleation process, single molecules would have to misfold and form toxic clusters unaided,
which is a much slower and far less devastating process. By studying the molecular processes by
and nucleating into toxic oligomers. The research team then carried out further tests in which living mouse brain tissue was exposed to amyloid-beta, the specific protein that forms the amyloid fibrils in Alzheimer disease.
Allowing the amyloid-beta to misfold and form amyloids increased toxicity in the tissue significantly.
but the toxicity did not develop in the brain tissue, confirming that the molecule had suppressed the chain reaction from secondary nucleation that feeds the catastrophic production of oligomers leading to Alzheimer disease.
which the group named teixobactin, was not toxic to human cells in a dish. And it showed other qualities of a good antibiotic,
But that would be toxic to living cells. To get around that problem, Demirci group fiddled not with the magnetic properties of the cells themselves,
000 gallons of toxic solvents and 100 kilograms of toxic cadmium waste in U s. production each year.
However large concentrations of ethanol can be toxic to yeast which has limited the production capacity of many yeast strains used in industry.
Toxicity is probably the single most important problem in cost-effective biofuels production says Gregory Stephanopoulos the Willard Henry Dow Professor of Chemical engineering at MIT.
which are even more toxic to yeast. The more we understand about why a molecule is toxic
and methods that will make these organisms more tolerant the more people will get ideas about how to attack other more severe problems of toxicity says Stephanopoulos one of the senior authors of the Science paper.
This work goes a long way to squeezing the last drop of ethanol from sugar adds Gerald Fink an MIT professor of biology member of the Whitehead Institute and the paper s other senior author.
They are also working on using this approach to boost the ethanol yield from various industrial feedstocks that because of starting compounds inherently toxic to yeast now have low yields.
which can be toxic so the parasite converts the iron into hemozoin a weakly paramagnetic crystallite.
whose production from raw ores can produce toxic residues, as a drawback. But by using recycled lead from old car batteries,
instead be used to divert toxic material from landfills and reuse it in photovoltaic panels that could go on producing power for decades.
Since this could expose miners and smelters to toxic fumes the introduction of recycling instead could provide immediate benefits,
oil-pipeline leaks can lead to toxic spills and prolonged, expensive cleanup operations. All of these systems could benefit significantly from improved leak-detection methods,
and we were intrigued very to observe that the DNA damage caused by this drug outside of the nucleus were highly toxic Kelley says.
Removing these toxic materials which include pesticides and endocrine disruptors such as bisphenol A (BPA) with existing methods is often expensive and time-consuming.
Brandl says. hen we came up with the idea to use our particles to remove toxic chemicals, pollutants,
minimizing the risks of leaving toxic secondary products to persist in, say, a body of water. nce they switch to this macro situation where theye big clumps,
but it does not contain toxic metals such as cadmium that are known to pose potential risks
Their toxicity has been researched in general terms but now a team of Israeli scientists has for the first time found that exposure nanoparticles (NPS) of silicon dioxide (Sio2) can play a major role in the development of cardiovascular diseases
Sio2 NPS are toxic to and have significant adverse effects on macrophages a type of white blood cell that take up lipids leading to atherosclerotic lesion development and its consequent cardiovascular events such as heart attack or stroke.
Here researchers have discovered for the first time that the toxicity of silicon dioxide nanoparticles has a significant and substantial effect on the accumulation of triglycerides in the macrophages at all exposure concentrations analyzed
and that they also increase oxidative stress and toxicity. A recent update from the American Heart Association also suggested that fine particles in air pollution leads to elevated risk for cardiovascular diseases.
"The chemicals that are used usually for this were just too toxic for me.""She preferred not to use cyanide, formaldehyde, arsenic and heavy metal salts.
because the components of such implants should be produced with as few toxic chemicals as possible."
By comparison other methods to make nanoporous graphene often use corrosive and toxic chemicals in systems that would be challenging to use at large commercial levels.
while traditional restoration techniques pose serious problems in terms of physicochemical compatibility with substances contained in artefacts and toxicity.
The lack of physicochemical compatibility between restoration materials and artefacts along with the former's toxicity were the two main aspects that prompted us to propose the NANOFORART project.
and are either not toxic or have reduced a significantly toxicity level compared to traditional restoration materials like solvents
What's so innovative about the solutions you propose? The advanced nanomaterials we have been working on allow for a more precise control of the restoration intervention for example controlled cleaning can be carried out using microemulsions and chemical hydrogels instead of traditional cleaning methods.
Future research in nanoparticle PTT will look at toxicity biodegradability and compatibility issues. Shi said that the team is currently looking for other diverse biodegradable materials to use for the carriers such as plant chlorophylls like those in cabbage that are both edible and photothermal.
000 gallons of toxic solvents and 100 kilograms of toxic cadmium waste in U s. production each year.
For example we can buy cockroach bait that contains a toxic substance to kill cockroaches. However the bait could potentially harm whatever else ingests it Zhu said.
If we can incorporate dsrna specifically targeting a cockroach gene in the bait rather than a toxic substance the bait would not harm other organisms such as pets
If the production of chitin can be reduced further the insects can be killed without using any toxic insecticides.
and toxicity said Dr. Zhen Gu assistant professor in the Joint Department of Biomedical engineering at NC State and UNC-Chapel hill.
and then deposit a microscopic amount on electrodes in a prototype handheld scanner that can detect toxic gases such as sarin or chlorine,
or toxic chemicals caught by the nanotube, you will see an increase or decrease in the current."
and about two-dozen different toxic gases, says Zang. The technology also can be applied to existing detectors
and because of their low toxicity they can be used as a carrier to transport drugs inside cells.
and chemical degradation can often be toxic and significantly perturb or even kill cells. There is a growing consensus among scientists that nanodiamonds are one of the best inorganic material alternatives for use in biomedical research, because of their compatibility with human cells,
a miniature device developed at the University of Montreal can measure a patient's blood for methotrexate, a commonly used but potentially toxic cancer drug.
"While effective, methotrexate is also highly toxic and can damage the healthy cells of patients,
"We were studying the toxicity of iron oxide nanoparticles in the waste treatment of anaerobic biological processes when we discovered that not only were they not toxic,
they actually stimulated the production of biogas, "he adds. Researchers saw this discovery as the opportunity to begin a business project
"Our business concept focuses on the design of processes with low energy, low toxicity, minimisation of waste and reduction of contaminating emissions",Víctor Puntes affirms."
Moreover graphene is nontoxic to biological systems an improvement over previous research into transparent electrical contacts that are much thicker rigid difficult to manufacture and reliant on potentially toxic metal alloys.
and reduce the possibility of toxic exposure due to excessive use of eye drops said Liu.
They can sense toxic chemicals and particles in the air and enzymes molecules and antibodies in the body that could indicate diabetes cancer and other diseases.
Because the toxicity of carbon nanotubes in biological applications remains an open question Pasquali said the fewer one uses the better.
controlling molecular assembly and avoiding toxic solvents like chlorobenzene. Now we have a rational way of controlling this assembly in a water-based system he says.
Numerous countries are developing strict regulations to avoid the trillions of toxic and non-biodegradable used-cigarette filters that are disposed of into the environment each yearur method is just one way of achieving this.
because these particles can be toxic in certain physiological conditions, "Dr Majumder said.""In contrast, graphene doesn't contain any magnetic properties.
Moreover, thanks to the inclusion of sulfur atoms, they are cheaper to make and less toxic than conventional lithium-ion power packs.
toxic liquids such as toluene and hexane are used usually as solvents in the carbon-carbon and carbon-nitrogen bond-forming reactions.
These toxic liquid solvents raise many issues for concern including environmental pollution, high cost of disposal, health problems and poisoning during the disposal process.
However, this new technology is able to replace those toxic liquids as it allows carbon-carbon and carbon-nitrogen bond-formation with the use of metal nanoparticles as a catalyst
and"hot injection"or other existing synthetic approaches are slow, costly, sometimes toxic and often wasteful.
Water-splitting photocatalyst that is abundant and inexpensive with low toxicity discovered More information: Amorphous Tio2 coatings stabilize Si Gaas and Gap photoanodes for efficient water oxidationn by S. Hu et al.
more selective and less toxic than the chromium used thus far. As such this new material provides high durability in the open air at temperatures of 300°C to 400°C,
and that are less toxic than chromium. That's why we followed the trail of these materials."
Just last year, more than 200 people in Lahore died after contaminated cardiac medicines containing a toxic amount of an anti-malaria drug hit the city's supply.
and is probably toxic. Too weak a signal means there might not be enough of the active ingredient to be effective (in antibiotics,
And about a quarter of all overdose death certificates don't have the toxicity test results listed at all landing them in the unspecified stripe.
Those methods still can't yield a toxic response and nullify the risks associated with smoking.
He further points out that two cancer bispecific antibodies on the market both have anti-CD3 arms. he key is to find the right balance between CD3 activation and toxicity,
drug discovery and chemical toxicity testing. In addition, they can be used to create next generation tissue engineered medical products that foster improved tissue integration and regeneration.
"Conventionally, cells cultured on the surface of plastic dishes have been used to identify new drug targets, test chemical toxicity,
less expensive ways to better predict human outcomes as part of drug development and chemical toxicity testing.
When healthy liver cells are depleted by long-term exposure to toxic chemicals, the newly discovered cells,
When healthy liver cells are depleted by long-term exposure to toxic chemicals, the newly discovered cells,
A version of the antibiotic was tested for toxicity in mice with no ill effects.""Within the next few years, we hope to identify various characteristics of these antibiotics,
would be beneficial in reducing toxicity because the amount of antibody could be decreased by two-thirds and the amount of chemotherapy by at least half.
#Graphene 3d files patent for low-cost, toxic-free process for producing high grade graphene for 3d printing Graphene 3d Lab has filed a non-provisionary patent pertaining to a new method for the preparation
high-energy and toxic chemical processes, limiting its use to certain R&d labs. Graphene 3d new process,
#ab-In-A-Needledetects Liver Toxicity In 30 Minutes The researchers are currently working on a prototype that miniaturizes a test lab into the size of a needle.
This ab-in-a-needledevice will be effective, for example, in quickly detecting liver toxicity, a common side effect of chemotherapy.
evaluate toxicity and display the results in one simple process. Dr. Wang Zhiping, Director of research Programs at Agency for Science, Technology and Research's (A*STAR) Singapore Institute of Manufacturing Technology (SIMTECH
manpower and costs and yet has the same accurate results as the gold standards of current liver toxicity tests, added Chang,
meaning that they can be left in the body without leaving a toxic residue behind.
and has observed no toxicity. Additional studies testing this formulation in rabbits undergoing cataract surgery are ongoing with Drs.
March 9) in the journal Scientific Reports, represents a major step forward in the development of accurate, faster methods of testing for drug toxicity.
so these differences often result in inefficient and costly experiments that do not provide accurate answers about the toxicity of a drug in humans,
it's also the improvement in targeting and reduction in toxicity, which is just icing on the cake.
Researchers in professor Margaret Frey lab create fibers hundreds of times thinner than a human hair that can capture toxic chemicals and pathogens.
and to capture toxic substances in liquids. Tiny, complex devices traditionally are made in high-tech clean rooms using expensive equipment and costly material, like gold.
This single, self-contained medical device will be effective, for example, in quickly detecting liver toxicity which is a common side effect of chemotherapy.
This device will test toxicity in 30 minutes while current liver toxicity tests take several days due to multiple steps required before a physician interprets the test results
and communicates them to the patient. Developed jointly by Houston Methodist Nanyang Technological University (NTU Singapore) and the Singapore Institute of Manufacturing Technology (SIMTECH), a research institute of the Agency for Science, Technology and Research (A*STAR),
The investigators demonstrated that two important steps of the lab in a needle approach accurately detected liver toxicity in preclinical models by measuring two genetic indicators of toxicity in AST and ALT.
evaluate toxicity, and display results in one easy-to-use process, allowing doctors and patients to immediately discuss treatment options.
Elevations in the two examined gene markers of liver toxicity were detected then accurately and consistent with previously known changes, indicating that lab in a needle is an appropriate diagnostic option."
researchers at The University of Texas at Austin have created a new flame retardant to replace commercial additives that are often toxic
these chemicals can migrate out of the products over time, releasing toxic substances into the air and environment.
this question of toxicity immediately goes away, "Ellison said.""We believe polydopamine could cheaply and easily replace the flame retardants found in many of the products that we use every day,
they can make the water toxic, and make it smell bad. At high concentrations, bacteria can be toxic in drinking water.
But at lower levels virtually undetectable by current culturing techniques they can cause an ff flavor,
and other microbes by detecting the off flavor they give off. ater that smells bad isn necessarily toxic,
it not that toxic but you don want to wear it because the smell is bad.
even if the water isn toxic, you don want to drink it. We wanted to develop a way to detect
when they are thought to be the most toxic.""It is extremely important that one develop techniques that allow us to detect the formation of these so-called amyloid fibrils
which the scientists injected the molecules that spontaneously form the toxic aggregates.""As aggregates grow on the membrane,
but containing no toxic platinum. Preclinical studies with various cultured human cells as well as on rodents show that these new molecules are effective against cervical,
which can potentially result in toxic by-products. Plus, these chemical degradation processes do not work on all types of chemicals. hen unusual/unheard of molecules are found as contaminants (for example, the chemical spill in Elk River, WV, in January 2014),
AD is believed to occur from the toxic buildup of beta amyloid. There are many forms of AD that are inherited genetically,
"and fail to identify all the toxic sequences that can trigger a celiac reaction. Armin Alaedini, assistant professor of medical sciences at Columbia University and a researcher at the New york-based school's Celiac disease Center, said the project may end up with a less toxic wheat product that isn't completely safe for all celiac disease patients."
"After all this effort, this product that is coming out...is unlikely to be superior in terms of nutritional value
Now a team from the University of Michigan Comprehensive Cancer Center offers a potential new target to block Notch without the toxic effects.
We think this would block the Notch cancer pathway without causing toxic side effects, like we see with current Notch inhibitors,
and to cure kids with fewer toxicities or long-term effects, "Chiang says.""Our current treatments may often be curative,
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