"The ability to precisely control droplets using fluidic computation could have a number of applications in high-throughput biology and chemistry,
Dmitry Fedyanin and Yury Stebunov, have developed an ultracompact highly sensitive nanomechanical sensor for analyzing the chemical composition of substances and detecting biological objects,
researchers make it react with specific substances or even biological objects. If you place antibodies to certain viruses on the cantilever,
and its mission is to seek nanotechnology solutions to challenges in the fields of biology, energy or technology.
Researchers in Sykes'lab are now assessing precisely how the low energy electrons travel through biological fluids.
Many other biological objects are composed also of these chiral biomolecules. In these compounds, the'left'form may be significantly different from the'right'form.
"said Dr. Carmen Gomes, Agrilife Research engineer with the Texas A&m University department of biological and agricultural engineering, College Station.
"I do the biological and polymer engineering; he does the electrochemistry and nanostructures, "she said.
As for the biological component, Gomes said she is using"nanobrushes"specially designed to grab particular bacteria.
builds on recent research by the same team that previously identified a fat-and-sugar molecule called GSL as the chief culprit behind a range of biological glitches that affect the body's ability to properly use, transport
#New Multispectral Microscope for Studying Impact of Experimental Drugs on Biological Samples This is the largest such microscopic image ever created.
This level of multicolor detail is essential for studying the impact of experimental drugs on biological samples
are present at each point in a single biological sample. harmaceutical research is awash with cutting-edge equipment that tries to image
and chemical processes that are taking place within a biological sample. This is essential for pharmaceutical research particularly cancer research--to observe how cells
and observe and study the biological and medical significance of RNA misregulation. Details will be published the week of July 20 in the journal Proceedings of the National Academy of Sciences (PNAS.
In particular, materials that mimic biological adsorbents like coral have potentially huge applications.""The researchers tested the coral-like nanoplates on removing mercury from water.
"We hope our work provides inspiration for more research into the development of materials that mimic biological organisms
which will allow sensors to be incorporated into electronic apparel for measuring biological data, including heart rate and muscle contraction.
environmental monitoring, and chemical, biological, radiological, nuclear, and explosives (CBRNE) detection. For more information, go to FLIR web site at www. FLIR. com o
The findings, published in Nature Chemical Biology, raise promise for medicine but also concerns about"home-brewed"illegal drugs.
A team of chemists and biologists at the Institute of Transformative Biomolecules (ITBM), Nagoya University have succeeded in finding new molecules that change the circadian rhythm in mammals by applying synthetic chemistry methods,
and worked closely with the biologists at ITBM to synthesize molecules for studying structure-activity relationships (SARS)."Through SAR studies on the molecular derivatives of KL001,
"says Takashi Yoshimura, an animal biologist and professor at ITBM, who also led this research from a biological perspective."
"It was found that the carbazole moiety was critical for rhythm-changing activity and that the substituents on the heteroaromatic ring are responsible for tuning the rhythm lengthening/shortening activities,
This is my first research outcome from the center's interdisciplinary collaboration between chemists and biologists,
and animal/plant biologists from different research groups work in the same lab space.""We hope we can make further use of synthetic chemistry to make bioactive molecules that can control the circadian rhythm of animals and gain further insight into the circadian clock mechanism,
These methods will help researchers determine which specific aspects of our biology are inherited, and uncover new insights into the genetics behind our countless biological processes."
Peter Facchini, professor in biological sciences, Jill Hagel, research associate, and Scott Farrow, Phd student. Many people who live in developing countries do not have access to the pain relief that comes from morphine or other analgesics.
"The findings were published July 1 in Nature Chemical Biology, and detail the missing step to morphine biosynthesis. Next steps Facchini says the isolation of this gene,
codeine and oxycodone,"says Facchini, professor of biological sciences in the Faculty of science and an internationally recognized expert on the opium poppy."
"This spatial differentiation happens in biology naturally, but we demonstrated this process in vitro, "said study lead author Zhen Ma, a UC Berkeley postdoctoral researcher in bioengineering."
Dean of the University of Leeds'Faculty of Biological sciences and Professor of Mechanistic Biology, said:"
"The implications for liver biology and drug discovery are said quite staggering Prof. Oren Shibolet, Head of the Liver Unit at the Tel-aviv Sourasky Medical center, who was involved not in this study."
Using previous studies into tumour biology, three mutations were identified in patients with gliomas. Tumours taken from glioma patients were scored as positive or negative for these mutations,
'Both studies can justifiably claim that molecular classification captures the biologic features of glioma variants better than does histopathological evaluation,
'Instead of starting from genetics, we've started with the biology of the disorder itself to try to get a window into the genome,
According to a recent review in Nature Materials making one billion human pluripotent stem cells with a polymeric substrate is ten to 15 times cheaper than using a biological equivalent like Synthemax,
According to a recent review in Nature Materials making one billion human pluripotent stem cells with a polymeric substrate is ten to 15 times cheaper than using a biological equivalent like Synthemax
#Building a Better Microscope to See at the Atomic Level One of the more famous images in biology is known as"Photo 51,
One of the more famous images in biology is known as"Photo 51, "an image of DNA that chemist Rosalind Franklin and Raymond Gosling created in 1952 by shooting X-rays through fibers of DNA
Yet biologists are interested particularly in these membrane proteins because the membrane is the cell dock, its security checkpoint, its mailbox.
biologists need to zoom in to the atomic level. The proteinsresistance to crystallization, therefore, left scientists in a bind.
you can make connections between the biology and chemistry, and it also provides capability for drug discovery
scientists didn believe electron microscopy would be useful for imaging proteins and other biological samples at all.
The problem was that electron microscopes work by shooting electrons at the speed of light through a biological sample suspended in a vacuum;
this process often destroyed the raw biological samples researchers were trying to see. Then in the 1970s and 1980s, researchers at Heidelberg European Molecular biology Laboratory and Lawrence Berkeley National Laboratory developed a way to protect samples
they rapidly freeze the purified biological samples in a very thin layer of liquid. Yet even when frozen at around-300°F,
Discovered in the 1970s, SERS is a sensing technique prized for its ability to identify chemical and biological molecules in a wide range of fields.
and measure chemical and biological molecules using a broadband nanostructure that traps wide range of light,
When a powerful laser interacts chemical and biological molecules, the process can excite vibrational modes of these molecules and produce inelastic scattering, also called Raman scattering, of light.
Kai Liu. he ability to detect even smaller amounts of chemical and biological molecules could be helpful with biosensors that are used to detect cancer,
They also provided evidence that the same approach could be applied to the limbs of primates. he composite nature of our limbs makes building a functional biological replacement particularly challenging,
and Microbial Biology at UC Berkeley. o one had been able to put all the pieces together before.
There is a lot of biology that we haven been able to understand from our current methods, Brown said.
and target research on"hotspots"most likely to be important for biological function. Known as SAPH-ire (Structural Analysis of PTM Hotspots), the tool could accelerate the search for potential new drug targets on protein structures,
"SAPH-ire predicts positions on proteins that are likely to be important for biological function based on how many times those parts of the proteins have been found in a chemically-modified state
"explained Matthew Torres, an assistant professor in the School of Biology at the Georgia Institute of technology.""SAPH-ire is a tool for discovery,
"Each PTM hotspot can then be ranked in order of highest to lowest potential for having significant biological function."
"Connecting SAPH-ire to other programs that convert mass spec data into actual PTM data could provide immediate biological relevance and prioritization for biochemists and others.
E. P. Taylor Professor of Pain Studies at Mcgill University and Director of the Alan Edwards Centre for Research on Pain. he realization that the biological basis for pain between men and women
Nanotechnology, Biology and Medicine, was led by Jeffrey Zink and Fuyu Tamanoi, both members of the California Nanosystems Institute and Jonsson Comprehensive Cancer Center at UCLA,
was carried out in collaboration with the School of Biochemistry at the University of Bristol, the Wound Biology Group at the Cardiff Institute of Tissue Engineering and Repair,
which are critical to the development of heart tissue. his spatial differentiation happens in biology naturally,
said Warren Ruder, an assistant professor of biological systems engineering in both the College of Agriculture and Life sciences and the College of Engineering."
understanding the biochemical sensing between organisms could have far reaching implications in ecology, biology, and robotics.
the research team included Professor Vladimir Tsukruk from the Georgia Tech School of Materials science and engineering and Rajesh Naik, Biotechnology Lead and Tech Advisor of the Nanostructured and Biological Materials Branch
or producing designer therapeutics--and perhaps one day even non-biological polymers. No one has developed ever something of this nature."
#Biodiesel production from Sugarcane A multi-institutional team led by plant biology professor Stephen P. Long from the University of Illinois reports that it can increase sugarcane's geographic range boost its photosynthetic rate by 30 percent
Long is an affiliate of the Institute for Genomic Biology at the University of Illinois s
#Uniting To Accelerate Pediatric Medicine Drug companies inherently absorb significant risk when developing compounds and biologics for clinical use.
whether the safety of concrete could be improved using a biological solution. This manufacturing query turned out to be the right question asked at the right time.
Jonkers said he hopes his concrete could be the start of a new age of biological buildings.
Dr Ivan Poon, a molecular biologist at La Trobe University who led the work, said they may have uncovered a key part of the immune systems defence mechanism.
'There is a lot of biology that we haven't been able to understand from our current methods.'
Can we take some inspiration from biology and create a skin-like display?''The team is able to change the colour on an ultrathin nanostructured surface by applying voltage.
Alicia Jackson, the deputy director of Darpa Biological Technologies Office In virginia, made comments alluding to the technology at a biotech conference on Monday. or the first time
'This spatial differentiation happens in biology naturally, but we demonstrated this process in vitro, 'said study lead author Zhen Ma, a UC Berkeley postdoctoral researcher in bioengineering.'
#Pop-up silicon 3d structures mimic biological structures A way to make pop-up silicon structures which can mimic the shape of biological structures like the veins
and brain cells has been found by researchers at Northwestern University, Illinois and the University of Illinois at Urbana-Champaign.
Complex three-dimensional (3d) structures in biology (e g.,, cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life.
spent two years using a PCC store as a iving laboratory to understand how food waste is created in a retail grocery environment. n 2010 the WISERG teamith the help of biologists, computer programmers and engineerseveloped a solution:
despite a vast number of examples in the biological world. The potential of evaporation to power engineered systems is neglected largely.
and demonstrated an implantable, cellular-scale microfluidic and micro-optical interface to biology, with application opportunities not only in the brain but in other parts of the nervous system and other organs as well, says the study other co-principal investigator, John A. Rogers, professor of materials science and engineering at the University of Illinois. For now,
and observe and study the biological and medical significance of RNA misregulation. Previous technologies made it possible to attain static snapshots of RNA location
biological agentsncluding mosquito-killing bacteria and fungind genetic manipulation of mosquitoes aimed at either killing them
The Shire-NPS deal comes less than two weeks before NPS faces a key decision from the FDAHETHER to approve its biologics license application (BLA) for Natpara
an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics appears in Genome Biology."
Marc Lecuit, M d.,Ph d.,Head of the Biology of Infections Unit at the Pasteur institute and senior author on the study,
"Dr. Toner and his colleagues anticipate that the Cluster-Chip will have an increasingly important role in stimulating new research on CTC cluster biology,
and to develop even better technologies to understand their biology in cancer metastasis. t
#Inexpensive Technique Developed to Manufacture Nanofibers Scientists at the University of Georgia say they have developed an inexpensive way to manufacture nanofibers,
"This discovery of a new prostate cancer-causing gene gives researchers a new avenue to explore the biology of the disease
thus streamlining a challenging step in the biologics manufacturing process within a small operating footprint. The technology will complement Pall's STAXTM depth filtration products to enable continuous clarification of cell culture, enabling integration of the bioreactor with downstream processing
"15-PDGH is a key enzyme responsible for the biological inactivation of a group of signaling molecules, called eicosanoids,
and paint the cells without affecting their biological function, said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
and paint the cells without affecting their biological function, said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
. Purdue's Walther Professor of Cancer Structural biology and professor of biological sciences and chemistry who leads the research team."
Implications for nsp5 regulation and the development of antivirals, June 8 in the Journal of Biological Chemistry.
when we combined Reuben's deep understanding of the fundamental biology of autophagy with our chemical expertise,"says Cosford."
"Our study has great biological and medical significance, particularly in light of the huge disease burden of malaria,"explained senior author Manoj Duraisingh, Ph d.,professor of Immunology and Infectious diseases at the T. H. Chan School of Public health."
"In addition to a possible drug target, calcineurin underlies a very basic aspect of parasite biology. l
With co-author and UW associate biology professor Jennifer Nemhauser, Ph d, . the UW team figured out how to make a sender yeast cell produce auxin,
In plants as in animals and humans, intricate molecular networks regulate important biological functions, such as development and stress responses.
which is linked to several vital biological functions in humans. The team study (tructural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors appears in Science Advances."
#Biopharma Demand Is Driving the Cell Culture Market The production of biologic therapies such as vaccines, blood factors,
and perhaps one day even non-biological polymers, point out Dr. Mankin.""We felt like there was a very small chance Ribo-T could work,
when my biology classmate inhaled a little too much ether while mouth-pipetting. Using a beam of IR light invisible to the fly,
Associate professor of biology Mark Schnitzer and his team were even able to perform behavioral studies with the robot,
In this way, the fluidic computer may find applications in such areas as biology, chemistry, and other physical sciences and technology that use processes more akin to the properties of organization found in nature."
and demonstrated an implantable, cellular-scale microfluidic and micro-optical interface to biology, with application opportunities not only in the brain but in other parts of the nervous system and other organs as well,"says the study co-author John Rogers,
said study author Dr Xianbiao Wang. e hope our work provides inspiration for more research into the development of materials that mimic biological organisms. r
and a Biotechnology and Biological sciences Research Council award, was published in the Science Translational Medicine journal in April.
This performance gap between software and wetware persists despite some correspondence between the architecture of the leading machine learning algorithms and their biological counterparts in the brain,
according to the request, such that dedicated exascale funding at the four DOE crosscuts Advanced Scientific Computing Research (ASCR), Basic energy Sciences (BES), Biological and Environmental Research (BER),
The scientists were trying to take the long-winding road from genetics to biology, which proved to be tedious and difficult.
Scientists can now directly study the biology of complex neurological disorders and from there nail down the responsible genes.
and this has got applications in chemistry, engineering, biology, medicine, so there's a lot of potential there and that's just for research purposes,
said Franco du Preez, a systems biologist and a founder of Lifeq. Over time, the system can identify qualitative trends such as the difference between someone having a jump in heart rate after a meal
Naturally curved, thin and flexible 3d structures are common in biology; examples include the circuits of brain cells and networks of veins.
and his colleagues want to create similarly complex devices that can wrap around these biological structures,
and the chipsclear polymer allows scientists to watch the small-scale biological processes in real time. he organs-on-chips allow us to see biological mechanisms
The device works by integrating biological spores which can expand or contract like muscles when exposed to different levels of moisture. ngineered systems rarely,
despite myriad examples of such adaptations in the biological world, wrote lead author Xi Chen
the ability to upconvert two low energy photons into one high energy photon has potential applications in biological imaging, data storage and organic light-emitting diodes.
the ability to upconvert two low energy photons into one high energy photon has potential applications in biological imaging, data storage and organic light-emitting diodes.
This study has brought together biologists and physicists from the Centre for Genomic Regulation (CRG) and the Institute of Photonic Sciences (ICFO
2015 Biologists and physicists have been working together to take a step forward in chromatin fibre observations and studies."
or precisely tailoring therapeutics to an individual's cancer cell biology. Toner and his collaborator Dr. Daniel Haber, M d.,Ph d.,also at MGH, recently used Cluster-Chip to capture
"Further analysis of the patients'CTC clusters yielded new insights into the biology of CTC clusters.
To characterize the biology of the clusters, the researchers measured a marker of tumor cell proliferation--an indicator of increased invasiveness and poor outcomes--in one breast cancer patient with high numbers of both single CTCS and clusters.
"Toner anticipates that the Cluster-Chip will play an important role in stimulating new research on CTC cluster biology:"
and to develop even better technologies to understand their biology in cancer metastasis
#Computing at the speed of light: Utah engineers take big step toward much faster computers The Utah engineers have developed an ultracompact beamsplitter--the smallest on record--for dividing light waves into two separate channels of information.
and biology,"says study co-senior author Euisik Yoon, Ph d.,professor of electrical engineering and computer science and of biomedical engineering and director of the Lurie Nanofabrication Facility at the U-M College of Engineering."
"In past decades, engineers have developed biological tools with better resolution, higher sensitivity, selectivity and higher throughput,
The goal of our lab is to develop tools that can be disseminated widely to the biology community to eventually impact clinical care for patients."
and graphene's electrical conductivity most likely contributed to the scaffold's biological success."Cells conduct electricity inherently--especially neurons,
The nanodrug can have a variety of chemical and biological"modules"attached.""Each component serves a specialized function,
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015engineering Phase changes in Nanoparticle Arrays:
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015nanostructures Increase Corrosion resistance in Metallic Body Implants May 24th, 2015iranian
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015engineering Phase changes in Nanoparticle Arrays:
"finding a nanothermometer sensitive enough at this scale is a great step forward in the field of nanotechnology, with applications in biology, chemistry, physics and even in the diagnosis and treatment of diseases
In Kinsis, material scientists, chemists, physicists, biologists, electrical engineers, information scientists, food scientists and physicians work closely together.
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015discoveries Tissue Engineering Scaffolds Produced from Natural Silk in Iran June 8th,
This substance has applications in the production of tissue engineering scaffolds as a biological material due to its appropriate mechanical properties and computability.
and that different physical mechanisms are used in different spectral bands to realize the same biological function of reducing body temperature.
Their discovery that there is a biological solution to a thermoregulatory problem could lead to the development of novel flat optical components that exhibit optimal cooling properties. uch biologically inspired cooling surfaces will have high reflectivity in the solar
if the ants were without the hair cover. he fact that these silver ants can manipulate electromagnetic waves over such a broad range of spectrum shows us just how complex the function of these seemingly simple biological organs of an insect can be,
Understanding and harnessing natural design concepts deepens our knowledge of complex biological systems and inspires ideas for creating novel technologies.
Can we take some inspiration from biology and create a skin-like display? As detailed in the cover article of the June issue of the journal Nature Communications,
and underwear incorporating sensing devices for measuring a range of biological indicators such as heart rate and muscle contraction.
This method is based on the standards of green chemistry due to the use of biological and green reactants instead of toxic chemicals and contaminants.
use of biological reactant and elimination of toxic and polluting materials and solvents are among the most important advantages of the proposed method.
in-vitro and in vivo biological testing), allowing researchers to fully comprehend the biodistribution, metabolism, pharmacokinetics, safety profiles and immunological effects of their medicinal nanoproducts.
*The technology was designed to track the machinery of biological cells, down to the tiniest bits of DNA, a single"base pair"of nucleotides among the 3 billion of these chemical units in human genes.
But the instrument could be useful well beyond biology, biochemistry and biophysics, perhaps in manufacturing.
The instrument must be stable to within about one-tenth of a nanometer (1 angstrom to biologists, equivalent to the diameter of a hydrogen atom.
and biological samples can be investigated today using X-ray tomography. This is done by recording images layer-by-layer
Researchers have developed a new approach for better integrating medical devices with biological systems. The researchers, led by Bozhi Tian,
The team achieved three advances in the development of semiconductor and biological materials. One advance was the demonstration, by strictly chemical means, of three-dimensional lithography.
The testing showed that the synthetic silicon spicules displayed stronger interactions with collagen fibers--a skin-like stand-in for biological tissue--than did currently available silicon structures.
or modifying the biological sample. Second, it stresses graphene's incredible potential in the area of sensing.##
the processing of the woolen fabric samples by using optimum amount of honeycomb nanocomposite such as N-Ag/Zno improves the biological, mechanical and hydrophilicity of the fabrics.
"Besides solar energy, the ability to upconvert two low energy photons into one high energy photon has potential applications in biological imaging, data storage and organic light-emitting diodes.
and transport proteins are amazing machines present in biological membranes, "said Manish Kumar, assistant professor of chemical engineering, Penn State."
and biology,"says study co-senior author Euisik Yoon, Ph d.,professor of electrical engineering and computer science and of biomedical engineering and director of the Lurie Nanofabrication Facility at the U-M College of Engineering."
"In past decades, engineers have developed biological tools with better resolution, higher sensitivity, selectivity and higher throughput,
The goal of our lab is to develop tools that can be disseminated widely to the biology community to eventually impact clinical care for patients."
and graphene's electrical conductivity most likely contributed to the scaffold's biological success."Cells conduct electricity inherently--especially neurons,
As the biology and technology become further refined the authors say that their approach could potentially be a more efficient, more effective,
Discovered in the 1970s, SERS is a sensing technique prized for its ability to identify chemical and biological molecules in a wide range of fields.
and measure chemical and biological molecules using a broadband nanostructure that traps wide range of light,
When a powerful laser interacts chemical and biological molecules, the process can excite vibrational modes of these molecules and produce inelastic scattering, also called Raman scattering, of light.
"The ability to detect even smaller amounts of chemical and biological molecules could be helpful with biosensors that are used to detect cancer, Malaria, HIV and other illnesses."
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