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Nanogel-Based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph node and Induces Potent Antitumor Immunity ACS Nano 2014 8 (9) pp 9209#9218.
We developed a nanoparticulate cancer vaccine by encapsulating a synthetic long peptide antigen within an immunologically inert nanoparticulate hydrogel (nanogel) of cholesteryl pullulan (CHP.
After subcutaneous injection to mice the nanogel-based vaccine was transported efficiently to the draining lymph node and was engulfed preferentially by medullary macrophages
The nanogel-based vaccine significantly inhibited in vivo tumor growth in the prophylactic and therapeutic settings compared to another vaccine formulation using a conventional delivery system incomplete Freund's adjuvant.
which may underlie the potency of the macrophage-oriented nanogel-based vaccine. These results indicate that targeting medullary macrophages using the immunologically stealth nanoparticulate delivery system is an effective vaccine strategy e
and circulating tumor cells than using the drugs in a nanogel delivery system without the platelet membrane. e like to do additional preclinical testing on this technique,
and TRAIL in a nanogel delivery system without the platelet membrane. e like to do additional preclinical testing on this technique,
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