and have anxiety (even) with getting gas, said Sandoval. ow we can have confidence to charge our electric vehicles and drive them from place to place (in Nevada).
or pump liquids in miniature devices used for chemical analysis. The conducting elastomers can be fabricated in diameters ranging from the very small about 150 microns
#Scientists grow human mini-brains that are giving big insights into autism Scientists first grew mini-hearts in a lab. Then they 3d printed skin.
Starting with skin cells from patient biopsies, scientists transformed them back into stem cells, and from those grew pea-sized,
In a study published last week in Cell, a team from Yale School of medicine used the technique to glean insight into why autism occurs in some people without a clear genetic cause.
Within a month, it was apparent that organoids created from people with autism overproduced one type of neuron that acts to dampen the chatter of normal neural activity.
and may in part cause the faulty wiring behind autism behavioral symptoms. Further sleuthing led the scientists to a single gene responsible for the glitch.
Before mini-brains, scientists had to shift through gobs of genomic data to fish out gene variants associated with autism.
This makes it much easier to home in on potential drug targets for therapy. Scientists also no longer have to solely rely on mouse models of human disorders.
If the rods and cones that make up the photoreceptors of the eye fail because of injury or illness,
and has restored already the sight of people with a specific form of blindness. About 200,000 people in the US have inherited diseases that cause problems for the photoreceptors in their eye.
#Machine that unboils eggs now being used to improve cancer treatment The device can rip things apart with great accuracy,
Using the invention on carboplatin a common cancer treatment drug, used against ovarian and lung cancers has boosted the potency by almost five times.
and this has got applications in chemistry, engineering, biology, medicine, so there's a lot of potential there and that's just for research purposes,
which could soon produce self-healing nail polish and a cure for cracked mobile phone screens. A team at the University of Bristol has been quietly developing the technology for the past three years.
assistant professor of Materials science and engineering at the Mccormick School of engineering and Surgery at the Feinberg School of medicine, has developed a new kind of graphene ink that can be used to print large 3d structures.
#Researchers Develop 3d printing Method to Produce Shell Capsules That Can Be loaded with Therapeutic Drugs Researchers at the University of Minnesota have introduced a novel 3d printing based method to produce highly monodisperse core/shell capsules that can
be loaded with biomolecules such as therapeutic drugs. They expect that this platform of 3d printed programmable release capsules will be useful in applications such as dynamic tissue engineering, 3d printed drug delivery systems, synthetic/artificial tissues, programmable matter,
once perfected, may open the door to a variety of new 3d printing applications within the art industry, medicine, aerospace, security, architecture, and more.
after fractures. While this 3d-bioprintable paste is yet to reach clinical trials, this study could be the first step to a revolutionary treatment method.
Potentially complicated applications such as filling bone fractures with this doughy material could make bones stronger during recovery from fractures.
The ELISA is a common diagnostic tool that requires large and expensive readout instruments that can only be found in well-equipped hospital labs. ELISA is not typically available in remote or developing countries in
The system, eautyexplorer, is targeted at beauty-treatment clinics, cosmetics makers, beauty product stores, etc. t is a product that proposes mental and physical cares,
The first, second and third elements are used for customer services at beauty-treatment clinics, cosmetics makers and beauty product stores.
the indexes of the effects of beauty-treatment that they received at clinics. Because the new system is targeted at women,
virus infections, scams, and data leakage. At the same time, based on activity logs on PCS, such as when the PCS freeze, they have developed a technology for calculating different usersrisks of being victimized.
which accumulate in tumor cells and scatter light making the tumors easy to see with a special camera.
The particles are each about 140 nanometers (0. 000005 inches) across and consist of eight-point gold stars that are surrounded by a layer of dye
because earlier efforts to make such nanoparticles weren't able to produce the consistent shapes needed said Dr. Moritz Kircher a molecular imaging specialist at Memorial Sloan Kettering Cancer Center in New york city.
so that they were very likely to develop cancer and injected them with the nanostars. The particles spread thorough the bloodstreams of the mice and built up in the cancerous cells.
and tumor cells that researchers had suspected existed but hadn't seen. It was thought precancerous cells also develop the larger pores like cancer cells.
The nanostars could be important in treating people with cancers in which the dangerous cells are sometimes hard to see such as liposarcoma a cancer that arises in fat cells.
You go in and open up the abdomen say and see all that fat Kircher said. You see some streaks that look abnormal
but don't know where edges of the tumor are. So doctors either have to take out all of the tissue that might possibly contain cancer
or risk leaving some cancerous cells in the body. These new nanoparticles would show where the dangerous cells are
and make the surgery a lot more precise he said. There are other benefits over earlier efforts Kircher said.
The nanostars are nonspecific they don't need to be custom-made for each type of cancer. Earlier experiments with nanoparticles often required them to be built to order coated with proteins that would link to specific types of cancer cells.
But before these nanoparticles get to the clinic there is still work to be done testing their toxicity
The work appears in today's (Jan 21) issue of Science Translational Medicine e
#Bye bye Baubles: New 3d printers Could Build Implants Electronics Several new 3d printers showcased at CES 2015 in Las vegas earlier this month suggest that the 3d printing industry best known for churning out brightly colored plastic doodads could be turning over a new
, more scientific leaf. Amid the rough-edged replicas of superheroes and army tanks that adorned the expo's 3d printing space stood a machine that prints tiny medical implants that dissolve inside the human body.
Another printer uses a combination of conductive inks and filaments to print quadcopters already embedded with the electronics that allow them to hover in the air.
One company displayed a prototype of a 3d printed medical device that can automatically stitch up patients after surgery.
Increasingly, this trendy technology is turning into a must-have tool for doctors, researchers and engineers, according to Nick Liverman, CEO and founder of Old world Labs (OWL), a Virginia-based company that designs dissolvable 3d printed implants.
"Liverman told Live Science. 3d printed implants OWL's MC-1 and MC-2 printers were both on display at CES.
For example, cancer researchers who want to deliver localized treatments to patients are using OWL's machines to build what Liverman called"microfluidic devices."
"You can also build custom implants, like tissue scaffolds, "Liverman said.""You can inject stem cells into the scaffold that you build with the printer
"7 Cool Uses of 3d printing in Medicine During cartilage replacement surgery, the scaffold containing the stem cells would be implanted in the knee,
From strings of lights adding holiday cheer to artificial sunlamps alleviating seasonal affective disorder, they brighten our days.
and nanotechnology as well as the completion of a device that may improve quality of life in indoor settings, from hospitals to underground parking garages.
how proteins aggregate in the earliest stages of diseases like Alzheimer and Huntington, has begun just.
Understanding disease progression at the single-molecule level could help identify when early intervention might be advantageous.
This results in disease that kills about 700,000 children every year, and stunts the physical and mental development of many more,
#Exoskeleton Helps Spinal cord Injury Patient Walk LAS VEGAS Bionic exoskeletons are helping spinal cord injury and stroke patients walk again.
One man with a partial spinal cord injury, Shane Mosko, demonstrated here today (Jan 8) at the 2015 CES how the new bionic legs operate,
More than 3, 500 patients with either spinal cord or stroke injuries have walked more than 15 million steps with the device,
The new exoskeleton can also help people with spinal cord injuries, like Mosko, who uses a wheelchair
Dr. Daniel Kraft, a pediatrician and the founding executive director of Exponential Medicine, at a talk here at the 2015 CES."
said Dr. David Landers, a cardiologist and cofounder of the Edgewater, N. J.,company that makes the device.
"We feel that the findings have potential relevance to a wide range of microsystems technologies biomedical devices, optoelectronics, photovoltaics, 3d circuits, sensors and so on."
however, is paralysis on either side of the body, which can cause loss of movement and diminished range of motion in the arms and legs.
Symptoms, Tests and Treatment In an effort to help patients regain movement on the side of their body affected by stroke, my colleagues at The Ohio State university Wexner Medical center and
Often, when those impairments have persisted even after completing 3 to 6 months of outpatient therapies,
doctors have not known how to reset the brain back into the state of rapid recovery that we see in the initial months after a stroke.
and we think that using a powerful magnet to enhance brain plasticity prior to therapies may be the solution.
Rebooting recovery Doctors think that part of the problem is that the healthy and injured sides of brains of some stroke patients develop an imbalance over time
either as a direct result of the tissue injury from stroke or through lack of use of the weaker side of the body.
Video game Therapy Proving Powerful for Stroke Patients (Op-Ed) The critical advance of this technology is the navigation tool,
The process helps improve the brain's receptiveness to activity-based therapy. The technology isn't limited solely to motor recovery after stroke in fact,
and arm therapy free of charge. The current Phase III clinical trial was launched in June 2014 and researchers will continue to conduct trials over the next 12 to 18 months.
We hypothesize that pretreatment with carefully dosed magnetic pulses to the motor cortex will predispose participants to make bigger gains with therapy than they would have with 6 weeks of therapy alone.
yet nonspecific, way of preparing the brain for all types of therapies, and depending on where the magnet is aimed,
can potentially affect many of the brain circuits that are impaired during stroke or other types of brain injuries.
we can vary the location of magnetic stimulation to target the brain regions associated with other neurologic impairments, e g.,
Thus, rtms treatment could be potentially improve aphasia, hemispatial neglect or pain perception resulting from stroke or brain injury.
This bodes well for neurorehabilitation programs in the future shedding light on the possibility that this technology might not be limited to stroke recovery alone a
#New Health Trackers Aim to Prevent Emergencies LAS VEGAS New health trackers aim to prevent health crises before they happen,
From sensors that aim to halt asthma in its tracks, to home monitors that warn the family
The Best Fitness Tracker Brands Derailing asthma Long before someone has an asthma attack there are warning signs that their respiratory function is going downhill.
"said Salman Bakht, the chief technology officer at Health care Originals, which makes a new asthma monitor called the Adamm.
But children and even adults often don't even realize they are having trouble breathing, especially if they've gotten used to their lungs functioning at a lower level than normal, Bakht,
who has told asthma Live Science. Adamm is a wearable, three-sensor monitor that will hit the market later this year.
so that chances can be made to their daily medicines or lifestyle. Is Grandma OK? Forget the cliché of dying alone and unnoticed till neighbors notice a funny smell.
Allergic response Another device, the Veta, made by Aterica, is essentially a smart case for an Epipen,
a name brand injection device that delivers the medication epinephrine to treat the life-threatening allergic response called anaphylaxis.
#Cholera Bacteria Spear Their Prey to Grab Genes The bacteria that cause cholera grab genes from other organisms in a particularly predatory way, new research finds.
But researchers at The swiss Federal Institute of technology in Lausanne, Switzerland, found that cholera (formally called Vibrio cholerae) have a unique way of doing so.
Cholera is usually found in water and it feeds on chitin, the stuff that makes up crustaceans'shells.
and the cholera bacterium absorbs the freed genetic material. The 9 Deadliest Viruses On earth Making these spikes in itself isn't that unusual,
This is, however, the first time anyone has observed cholera bacteria or any bacteria using this system to gather up new genes.
Cholera makes people sick when it is ingested. The bacteria gets to the small intestine and then multiplies, producing proteins that are toxic to humans and cause watery diarrhea.
That in turn can cause severe dehydration and an imbalance of electrolytes. Without treatment cholera can be deadly.
Humans can build immunity to some strains of cholera. But sometimes, new strains appear, and the transfer of genes from other species of bacteria (including other kinds of cholera) might be one reason these new strains arrive."
"That's what we think what we see is part of what makes the most virulent strains so virulent,
"said Melanie Blokesch, a co-author of the research and an assistant professor of microbiology at the institute.
Not every kind of cell can contribute DNA to cholera, as there has to be some similarity between the cholera cell and its victim,
Blokesch said. Even so, some genes might alter the outer membrane of the bacteria, for example, making it less visible to the human immune system or tougher for people's stomach acid to kill.
This kind of gene transfer might well have been involved in a cholera epidemic that hit Southeast asia in the early 1990s
Blokesch added that the spearing mechanism might be one more reason the cholera bacterium is so virulent in the human gut.
Cholera might be spearing neighboring cells, killing them and exacerbating the problems it causes. Cholera won't pick up human DNA,
however, because it is too different.)The study appears today (Jan 1) in the journal Science S
so that Sorto can use it outside the lab. Andersen is working with two other patients in the United states who also have prostheses that include neural implants.
#1 Pinprick Test Could Detect Hundreds of Viruses Doctors often don't have a complete picture of their patients'health histories they only know about past illnesses that a patient remembers
whether they've been exposed to certain diseases. But now, researchers at Brigham and Women's Hospital in Boston say they have created a tool that could reveal many of the viruses that have infected a person in the past.
Called Virscan, the test looks for hundreds of viruses at once, and does so at a fraction of the cost of traditional tests,
the group ran the scan on people known to be infected with hepatitis C and HIV.
"Kula said this finding showcased one of the big advantages of this method of testing for a person's viral infection history:
chronic fatigue syndrome that researchers suspect may be caused by a virus but haven't proven for sure to have a viral origin.
if individual viruses are correlated to other diseases, or try to figure out why only a fraction of patients"are helped by certain cancer treatments,
Kula said. Because the new test is relatively cheap Kula noted the chemicals necessary are a few dollars per person,
or perhaps even less it could also help doctors and patients by detecting their exposure to a virus they weren't aware of.
Hepatitis C, Kula said, is detected often not for months or years, because few people think to ask about it.
#Shaping Implantable Medical devices to Avoid Immune system Tiny medical implants that can ferry drugs, cells, or other therapies safely to sites of disease are already seeing the light of day.
Designing implantable devices that are ignored by the immune system can be a challenge, so we usually rely on materials that are naturally biocompatible.
The team was developing implantable capsules that can hold pancreatic islet cells as a potential therapy for Type 1 diabetes.
What investigators discovered is that spherical capsules 1. 5 millimeter in diameter were functional months after implantation in diabetic mice,
#Injectable Hydrogel Material Serves as Scaffold to Heal Wounds At UCLA researchers have designed an injectable hydrogel scaffold that promotes wound healing by serving as a 3d platform within which new tissue can grow.
as well as the overall chemical composition, allowing the material to be tailored to specific wounds. This is achieved using microfluidic methods methods that the researchers developed to produce the scaffolds.
Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blockssource:
#Light Used to Control Larynx Muscle (VIDEO) In a world first, researchers at the University of Bonn in Germany made a skeletal muscle of a mouse contract in response to light.
The hope is that this new application of optogenetics to voluntary muscles will help in medical research
particularly for new therapies to combat motor neuron disease. Here we show direct optogenetic stimulation of skeletal muscle from transgenic mice expressing the light-sensitive channel Channelrhodopsin-2 (Chr2.
Furthermore, systemic injection of adeno-associated virus into wild-type mice provides sufficient Chr2 expression for optogenetic opening of the vocal cords.
#Rice Microendoscope Hopes to Make Esophageal Biopsies Thing of Past (VIDEO) At Rice university engineers have been working on making certain biopsies unnecessary by imaging suspected tissues without excising them.
offering a view of the cellular morphology that can show signs of the presence of cancer.
and China of patients suspected of having malignant squamous cell tumors, the device was used alongside a regular endoscope.
Results of biopsies ordered after a traditional endoscopic imaging were compared with the results from the microendoscope.
These showed that the technology is capable of sparing patients unnecessary biopsies and can be used alongside traditional Lugol chromoendoscopy for diagnosing esophageal squamous cell neoplasia.
Three expert and four novice endoscopists performed white light endoscopy followed by LCE and HRME. All optical images were compared to gold standard of histopathology.
Using a per biopsy analysis, sensitivity of LCE vs. LCE+HRME was 96%vs. 91%(p=0. 0832), specificity 48%vs. 88%(p<0. 001), PPV 22%vs 45%(p
With use of HRME, 136 biopsies (60%;%95%CI: 53-66%)could have been spared, and 55 patients (48%;
38-57%)spared any biopsy y
#Robotic Arm System Senses Quadriplegic Man Intentions for Movement Control Brain-computer interfaces have been used in the past to control prosthetic devices.
In a study on one paralyzed patient, two implants, each having 96 electrodes, each of which sample one neuron,
somewhat unusual shape that was developed to offer greater comfort to those wearing the implant. It smaller than any other comparable device and unlike other primary cell systems, it comes with a wireless remote that can be used by the patient to adjust therapy options.
The device is programmed via the Illumina 3d software that takes into account the spatial positioning of the leads
said Dr. Simon Thomson, a consultant in Pain Management and Neuromodulation at Basildon and Thurrock University Hospitals, UK. he simplicity of the programming software saves valuable time in the operating theatre,
and maintain comfortable therapy for my patients. Unlike any other primary cell system, the Precision Novi intuitive Illumina 3d neural targeting software incorporates three-dimensional lead location,
and waveforms with or without paresthesia, including burst and higher rate frequencies. Here a Boston Sci video about the Precision Novi r
where glucose charts and insulin injections are tracked automatically. The readings can be shared with loved ones and caretakers,
Since there no need to swap tools, the procedure can move along faster without the potential risk of unnecessary injury to the esophagus.
allows the surgeon to see its location from the outside. This provides the ability to align the dissection line accurately along the light path
in a statement said Chris Barry, senior vice president and president of the Surgical Innovations business, Minimally Invasive Therapies Group at Medtronic. orking very closely with Dr. Trivedi, we were able to develop the Gastrisail system as a unique solution that promotes consistency of the sleeve,
but also procedural efficiency. roduct page: Gastrisailource: Medtronic o
#Scientists Grow, Link Up Brain cells for First time in a Lab While most differentiated cells can be made to live on their own,
Study in journal Restorative Neurology and Neuroscience: A new technique for modeling neuronal connectivity using human pluripotent stem cellsource:
Because of its high flexibility, the stent has shown to be positioned easily across different lesions while and maintaining its strength over considerable time periods.
or equal 2. 4). 88.6%freedom from target lesion revascularization, as measured at one-year using Kaplan-Meier analysis s
#Researchers Unveil Surface Sampling Probe for Intraoperative Biopsies The Oak ridge National Laboratory, known best for nuclear weapons research,
has developed a surface sampling probe that may replace professional pathologists in identifying cancerous tissue during surgeries.
Currently, samples are taken to the pathology lab to confirm that all of the cancer has been removed. This takes considerable time,
and adrenocorticotropic hormone (ACTH) from normal human pituitary gland and pituitary adenoma tissue sections, using a fully automated droplet-based liquid-microjunction surface-sampling-HPLCSI-MSS system for spatially resolved sampling, HPLC separation,
and non-secreting pituitary adenomas correlated with histopathological evaluation a
#Brainport V100 Turns Your Tongue Into an Eye If you can see with your eyes,
With Brainport Vision Technology One Day The Blind May See The World With The Tongue New Device Delivers Sound Through Tongue to Let Deaf People Hear (VIDEO) roduct page:
#Optical Probe to Help Remove Only Cancerous Tissues in Brain Surgeries Neurosurgeons removing a tumor have to be obsessive about resecting just enough
so that the cancer doesn come back while the patient is not left neurologically disabled. Tumors usually look the same as the healthy tissue just around them,
which means the repeated biopsies and MRI scans can make such surgeries last for many hours.
Now researchers at Johns hopkins university are reporting on a new optical coherence tomography (OCT) probe that may provide surgeons real-time identification of cancerous tissues.
Previously the fact that tumors tend to be denser was the basis for many designed devices,
but the Hopkins team focused on brain cancer cellslack of myelin sheaths as the marker that influences how light passes through them.
Having identified how brain cancer cells uniquely scatter light, the researchers wrote a computer program that spots the relevant parameters within OCT scan data.
The results come back as a 3d color map of the tissue under the probe, red colored areas pointing to cancerous regions
Here an example of the probe being used on brain tissue removed in actual surgeries: Study in Science Translational Medicine:
Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomographyource: Johns Hopkins Medicine
#Electromagnetic field Activated Drug Loadded Nanowires Drug releasing implants can be of great benefit for conditions requiring long term treatment in a targeted area of the body.
There are existing devices on the market, but they tend to be bulky and involve electronics, mechanical valves,
and other components that create their own drawbacks. Researchers at Purdue University have come up with a new way of releasing drugs into the body in a controlled manner using tiny injectable nanowire implants.
The devices are made of polypyrrole, an organic electrically conductive polylmer. A small carpet made of these wires was grown over a gold base
The team tested the technology on mice with compression injuries, demonstrating that the drug reduced inflammation in the areas where the EM field was applied.
and deposited onto a spinal cord lesion in glial fibrillary acidic protein-luc transgenic mice (GFAP-luc mice). Overexpression of GFAP is an indicator of astrogliosis/neuroinflammation in CNS injury.
The corticosteroid DEX, a powerful ameliorator of inflammation, was released from the polymer by external application of an electromagnetic field for 2 h/day for a week.
#Artificial Neurons That Work Like Real Ones to Treat Neurological Conditions, Paralysis Researchers at the Karolinska Institutet in Sweden have created reportedly an artificial neuron that apparently works just like our own living neurons
The big deal for clinical applications is that this technology may allow for chemical stimulation of neurological conditions triggered by naturally occurring biochemicals.
and delivering therapy consistently at all times. The current device is still quite bulky and is incomparable in size to natural neurons,
The company microchips have gone already through a successful clinical trial on patients with osteoporosis, delivering teriparatide directly without having to go through regular injections.
Flashbacks: Wireless Implantable Microchips Deliver Drugs When Needed Continuous Microchips Glucose Monitoring Shows Promiseompany homepage:
This method is used to study the spatiotemporal mechanical response of MDA-MB-231 breast carcinoma cells to the inhibition of Syk protein tyrosine kinase giving insight into the signaling pathways by which Syk negatively regulates motility of highly invasive cancer cells.
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