researchers at The University of Texas at Austin have created a new flame retardant to replace commercial additives that are often toxic
these chemicals can migrate out of the products over time, releasing toxic substances into the air and environment.
this question of toxicity immediately goes away, "Ellison said.""We believe polydopamine could cheaply and easily replace the flame retardants found in many of the products that we use every day,
#Nanoscale DNA Machine Could Detect HIV Diagnostic Antibodies New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases such as rheumatoid arthritis and HIV.
An international team of researchers have designed and synthetized a nanometer scale DNA"machine "whose customized modifications enable it to recognize a specific target antibody.
Their new approach, which they described this month in Angewandte Chemie, promises to support the development of rapid,
low-cost antibody detection at the point-of-care, eliminating the treatment initiation delays and increasing healthcare costs associated with current techniques.
The binding of the antibody to the DNA machine causes a structural change (or switch
and is rapid-acting within five minutes-enabling the targeted antibodies to be detected easily, even in complex clinical samples such as blood serum."
so that it can detect a huge range of antibodies, this makes our platform adaptable for many different diseases"."
""Our modular platform provides significant advantages over existing methods for the detection of antibodies,"added Prof.
a collaboration of Indian and American scientists have identified a malarial parasite protein that can be used to develop antibodies
enolase, is a protective antigen and has several other functions that are essential for parasite growth and multiplication.
antibodies against this small fragment can potentially have a dual benefit by blocking the multiplication cycle of the parasite in humans,
Dassarma, Phd, a professor of microbiology and immunology at the school,"GVNPS offer a designer platform for vaccines
antibodies directed against it are likely to protect against all species of the parasite, "says Sneha Dutta,
they can make the water toxic, and make it smell bad. At high concentrations, bacteria can be toxic in drinking water.
But at lower levels virtually undetectable by current culturing techniques they can cause an ff flavor,
and other microbes by detecting the off flavor they give off. ater that smells bad isn necessarily toxic,
it not that toxic but you don want to wear it because the smell is bad.
even if the water isn toxic, you don want to drink it. We wanted to develop a way to detect
when they are thought to be the most toxic.""It is extremely important that one develop techniques that allow us to detect the formation of these so-called amyloid fibrils
which the scientists injected the molecules that spontaneously form the toxic aggregates.""As aggregates grow on the membrane,
and amount of specific antibodies reacting to the toxins.""Having an early diagnosis means patients can avoid years of invasive tests and visits to specialists that often leave them with more questions than answers,
The blood tests identified the two antibodies associated with IBS--anti-Cdtb and anti-vinculin--with greater than 90 percent certainty.
developed by Pimentel to detect both anti-Cdtb and anti-vinculin antibodies in the diagnosis of irritable bowel syndrome and inflammatory bowel disease.
#Detecting HIV diagnostic antibodies with DNA nanomachines New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases.
New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases such as rheumatoid arthritis and HIV.
An international team of researchers have designed and synthetized a nanometer scale DNA"machine "whose customized modifications enable it to recognize a specific target antibody.
Their new approach, which they described this month in Angewandte Chemie, promises to support the development of rapid,
low-cost antibody detection at the point-of-care, eliminating the treatment initiation delays and increasing healthcare costs associated with current techniques.
The binding of the antibody to the DNA machine causes a structural change (or switch),
and is rapid-acting within five minutes-enabling the targeted antibodies to be detected easily, even in complex clinical samples such as blood serum."
so that it can detect a huge range of antibodies, this makes our platform adaptable for many different diseases"."
""Our modular platform provides significant advantages over existing methods for the detection of antibodies,"added Prof.
and the other--based on an antibody called VRC07--powerfully binds to more than 90 percent of HIV strains.
and Richard A. Koup, M d.,VRC deputy director and chief of its immunology laboratory a
#Breakthrough in rare disease that causes growth of second skeleton Scientists have developed a potential antibody treatment for the rare genetic disease fibrodysplasia ossificans progressiva (FOP), in
They injected an antibody that blocks Activin-A into mice that had been engineered genetically to have symptoms similar to FOP.
as a biotechnology company with expertise in developing antibodies, they are in a position to act on it
and antibodies using the tech. The team still has to contend with a host of regulatory issues,
and antibodies using the tech. The team still has to contend with a host of regulatory issues
but containing no toxic platinum. Preclinical studies with various cultured human cells as well as on rodents show that these new molecules are effective against cervical,
a professor of immunology and infectious diseases at Harvard School of Public health who was involved not in the research. trikingly,
and seasonal flu outbreaks because it's focusing on host immunity, "said Chakravarthy.""We hope our study opens the door to the development of new drugs
The international team found that the toxin split apart the red blood cells by attaching itself first to their so-called Duffy antigen protein receptor
Torres also has plans to study groups of Africans known to be genetically deficient in Duffy antigens and, hence, more resistant to malaria,
which can potentially result in toxic by-products. Plus, these chemical degradation processes do not work on all types of chemicals. hen unusual/unheard of molecules are found as contaminants (for example, the chemical spill in Elk River, WV, in January 2014),
AD is believed to occur from the toxic buildup of beta amyloid. There are many forms of AD that are inherited genetically,
Dr. Goberdhan's and Prof Harris's groups collaborated to develop an antibody that could be used to highlight PAT4 in human tissue samples.
A later step will be combining the proteins with antibodies produced by the human immune system to test for reactions.
"and fail to identify all the toxic sequences that can trigger a celiac reaction. Armin Alaedini, assistant professor of medical sciences at Columbia University and a researcher at the New york-based school's Celiac disease Center, said the project may end up with a less toxic wheat product that isn't completely safe for all celiac disease patients."
"After all this effort, this product that is coming out...is unlikely to be superior in terms of nutritional value
researchers from the University of Montreal describe a novel way to detect large molecules like antibodies in blood using a quick,
"What these tests are looking for is antibodies proteins that are generated by the body in response to viruses or bacteria.
if you have the antibody. And in principle, you can detect any antibody you want.""Electrical current Vallée-Belisle and his team, working with a chemist from the University of Rome, came up with a way to detect antibodies by having them bind to loose, single strands of DNA.
Those single strands then attempt to pair up with nearby complementary strands to form the characteristic DNA double helix.
The researchers designed the single DNA strands so that if no antibodies are present when they bind with their complementary pairs, a detectable electrical current flows.
But if antibodies are present and attached to the loose strands, the current drops. The drop is so precisely measurable that the test can even be used to determine how much antibody is in a sample
instead of simply indicating its presence or absence. They call the process"electrochemical steric-hindrance hybridization assay,
"or eshha, because it takes advantage of how the DNA molecules react in the presence of other larger particles, an effect known as"steric hindrance."
"Biochemistry professor Kevin Plaxco of the University of California at Santa barbara, who supervised Vallée-Belisle's previous postdoctoral work and who is himself an expert in electrochemical methods to detect antibodies,
There are currently point-of-care antibody tests on the market for diagnosing HIV within minutes,
quantifiable data on how much antibody was found. That might not be needed for HIV, but it could be useful for doctors treating autoimmune diseases,
STD screening in minutes The Montreal researchers'method would also allow for simultaneous testing for the presence of more than a dozen different antibodies,
and will soon publish research showing they can also detect three of the various HIV antibodies.
After that, they're also aiming to detect antibodies for syphilis and herpes. One of the big advantages of their method is its cost:
#Scientists brew cannabis chemical THC for better drugs for cancer sufferers An active ingredient typically found in cannabis has been engineered genetically in the lab for the first time.
Scientists said the real challenge is to devise a method that works better than cannabis plants themselves.
easier way to create this cannabis component from scratch. Ordinarily, the chemicals are stripped from the plants themselves,
Although a significant breakthrough, this still means that cannabis plants are by far the best producer of the psychoactive molecule.'
Scientists said the real challenge is to devise a method that works better than cannabis plants themselves.
easier way to create this cannabis component from scratch, Ordinarily, the chemicals are stripped from the plants themselves,
His 2003 proposal to conduct immunology and virology of the patients receiving ART during the SPARTAC trial
blood coagulation and immunity. Honing in on individual examples, the researchers were able to track each of them through time
The work builds on two back-to-back studies the Chen lab published in Science in late 2012 that identified cgas as a sensor of innate immunity-the body's first line of defense against invaders.
Now a team from the University of Michigan Comprehensive Cancer Center offers a potential new target to block Notch without the toxic effects.
Results of the study are published online in the journal Immunity.""Our goal is to develop a drug to sit right between Notch
We think this would block the Notch cancer pathway without causing toxic side effects, like we see with current Notch inhibitors,
and to cure kids with fewer toxicities or long-term effects, "Chiang says.""Our current treatments may often be curative,
The most common approach is to make a sandwich of a"primary"antibody specific for a certain protein on a cell
and a"secondary"antibody connected to fluorophores. But if a protein is expressed at a low level,
In those cases, many fluorophores are attached to the secondary antibody to amplify the signal. However, there's a limit to that strategy
The bottlebrush structure could then serve as a new type of secondary antibody that could bind to thousands of fluorophores,
The study is published in the prestigious journal Immunity.""The discovery of MYSM1 is a major milestone in our understanding of how our immune system works,
The targeted delivery system also used far less drug than used in traditional chemotherapy, saving healthy tissue from toxic exposure.
blood coagulation and immunity. Honing in on individual examples, the researchers were able to track each of them through time
excretion and toxicity")studies of the compound's behavior within the organism, a necessary step before carrying out clinical trials.
After six months, those who benefited from the drug were allowed to continue treatment with continued follow-up appointments to monitor toxicities.
which to make antibodies for pharmaceutical use e
#Researchers develop deep-learning method to predict daily activities Researchers from the School of Interactive Computing
#Colorado river is contaminated after mine cleanup goes wrong Workers from an environmental protection team have caused accidentally an environmental disaster releasing millions of litres of toxic wastewater into a river in Colorado.
#Medical marijuana Sparks New Technology The emerging cannabis industry has created not only thousands of new jobs, it has also given birth to a new technology niche.
The low hanging fruit was the copy cat web design for internet cannabis sites based on already popular traditional internet sites.
and Weedmaps is the rouponof cannabis with its daily deals. Weedhire is the equivalent of Monster. com for its marijuana jobs.
government agencies have also been challenged with meeting the specific requirements of complicated cannabis legislation. Since each state is unique in its regulations,
It was one of only a handful of American companies at the World Cannabis Conference in Spain.
NIC targets the government as its client in the cannabis space. It specializes in helping the government agencies tasked with creating a marijuana department.
Product testing is another cannabis hot button issue. In the early months of retail marijuana in Colorado, customers became confused as to how much THC was in the product they bought.
Amercanex is creating a cannabis commodity exchange with the plan for a futures market. Not unlike the other commodities exchange, this platform will allow cannabis farmers to lock in prices for their crops
and for buyers to secure their inventory. Steve Janjic, CEO of Amercanex said his company is looking ahead to
He said the problem with the cannabis tech companies is a lack of access to institutional money.
Banking is another problem for the cannabis industry causing businesses to become very creative in order to process transactions.
if Bank of america decides cannabis won get them in trouble with the Feds. In the meantime these new companies aren letting any grass grow beneath their fee t
Various cartels are using drones to send methamphetamine and other narcotics over the heads of authorities.
sense motion from a person in the vicinity as well as sensing odors and potentially toxic chemicals in the air.
and traveling to immunization camps in Africa and to Geneva to learn about public health policy.
and respond to toxic injury in ways that are similar to kidney tubules in people.
"This establishes an entirely new toxicity mechanism. e
#Engineering Therapeutic Proteins into Antibodies Scientists at the Scripps Research Institute (TSRI) have devised an improved method for building proteins into larger proteins such as antibodies.
The new technique mimics evolution by generating millions of possible junction segments between the inserted protein
and its antibody host, selecting the rare ones that allow the inserted protein to fold
In one proof-of-principle demonstration, the team edited the genetic code of a standard human antibody to replace one of its target-grappling elements structure that normally would bind to a virus
if it were part of a larger structure such as an antibody.""The major challenge for Dr. Lerner, Peng and their colleagues was to design leptin into an antibody in such a way that it would fold up into a functional structure
despite being bound to its host protein at either end. Designing simple, highly flexible"junction"segments to join leptin to an antibody could work a recent paper (www. ncbi. nlm. nih. gov/pubmed/25605877) by a group including TSRI's Peter Schultz, Ph d,
. Scripps Family Chair Professor of Chemistry, described such a feat. But Dr. Lerner's team reasoned that a selection-based design of these junctions would be a more general approach to making useful protein-in-protein molecules.
Using their established techniques for generating large libraries of variant antibodies the team made nearly 30 million versions of the leptin-in-antibody protein,
each version having a different amino-acid sequence for its junction segments. To find the rare versions that enabled leptin to fold up
and function properly, the researchers used a selection system that they had developed previously for finding therapeutic antibodies in large antibody libraries.
First they employed viral vectors to insert the leptin-in-antibody DNA into test cells that contain leptin receptors.
When one of the resulting leptin-in-antibody proteins successfully activated a leptin receptor in its test cell,
The cells whose beacon signals rose above a certain threshold were analyzed for the leptin-in-antibody DNA they contained,
until the process yielded the leptin-in-antibody protein that did best at activating the leptin receptor.
As is often the case for antibodies the leptin-in-antibody protein effectively could not cross from the bloodstream into the brain
and thus could not hit all of leptin's neuronal targetsnd so its effects at reducing eating
But, in principle, antibodies can be modified to enable them to cross the blood-brain barrier more easily, and the team is working on that now.
the researchers also used it to"selection-design"an antibody that incorporates the growth and reproductive hormone FSH,
The resulting FSH-in-antibody protein showed activity against the FSH receptor that was virtually the same as the natural hormones.
The team is now working to improve their FSH-and leptin-in-antibody proteins, and to design entirely new protein-in-antibody molecules l
#Expanding the Super-Resolution Arsenal Technological advances in the field of microscopy and imaging have seen a flurry of activity over the past several years,
antibody-like proteins they call monobodies. The investigators were able to change the specificity of an enzyme,
While an average adult residing within a malaria endemic region possesses some immunity to the parasite, pregnancy causes complications that leave women and fetuses extremely vulnerable.
"There is some irony that a disease as destructive as malaria might be exploited to treat another dreaded disease,"stated lead author Ali Salanti, Ph d.,professor of immunology and microbiology in the Centre for Medical Parasitology, at the University
But now, researchers have developed genetically modified salmonella that turns toxic only after it enters a tumor.
"This transition from a benign, invasive Salmonella that doesn't hurt normal cells to the toxic type occurs very rapidly (time wise) in the tumor due to the very rapid growth
in the ambulance as soon as there are symptoms.""Tissue plasminogen activator (tpa) is another common form of blood-clot medication.
Typically a toxic shampoo or lotion has to first be applied to the sufferer's scalp, after
Goberdhan team created an antibody that let them see levels of PAT4 in human tissues.
"We identified for the first time a pharmacological approach that reverses all aspects of tau toxicity, "said Gan in a statement."
so we are getting a targeting effect using the nanoparticle that you couldn get with a soluble antibody,
this development can also reduce potentially harmful waste from LEDS generally made from toxic elements.
CDS have lower toxicity and better biocompatibility, meaning they can be used in a broader variety of applications.
a compound comprised of a two toxic elements. The ability to create QDS in the form of CDS from food
as the food and beverages themselves are not toxic. Ds derived from food and beverage waste are not based on common toxic elements such as cadmium and selenium,
which makes their processing and disposal more environmentally friendly than it is for most other QDS.
In addition to being broken toxic when down, cadmium selenide is also expensivene website listed a price of $529 for 25 ml of the compound. ith food
and respond to toxic injury in ways that are similar to kidney tubules in people.
Traditional methods use methanol, a toxic solvent. Subcritical fluid technology uses water above its boiling point and below its critical temperature, under pressure.
narcotics or paralytics to keep them breathing.""Holidays are spent not in the hospital anymore, "Green said."
whether polythiophenes could be given safely to people their toxicity is known not yet, and even further away are tests studying
They said that the antibodies used in the original study were not specific, meaning that they reacted to other proteins in the blood besides irisin.
The initial study did not show that any toxic by-products were created in the blood. The hope is continued that with study,
The drug-loaded nanocapsule is coated with an antibody that specifically targets activated platelets, the cells that form blood clots,
Their porous properties have led to proposed application in carbon capture, hydrogen storage and toxic gas separations,
#Detecting HIV diagnostic antibodies with DNA nanomachines A nanoscale machine composed of synthetic DNA can be used for the rapid,
cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases such as rheumatoid arthritis and HIV.
"whose customized modifications enable it to recognize a specific target antibody. Their new approach, which they described this month in Angewandte Chemie,
low-cost antibody detection at the point-of-care, eliminating the treatment initiation delays and increasing healthcare costs associated with current techniques.
The binding of the antibody to the DNA machine causes a structural change (or switch),
and is rapid-acting within five minutes-enabling the targeted antibodies to be detected easily, even in complex clinical samples such as blood serum."
so that it can detect a huge range of antibodies, this makes our platform adaptable for many different diseases"."
""Our modular platform provides significant advantages over existing methods for the detection of antibodies,"added Prof.
The light-generating DNA antibody detecting nanomachine is illustrated here in action, bound to an antibody o
Toxicity and cancer-cell resistance can also compromise the effectiveness of radiation and chemotherapy that's often used as a follow-up to surgery.
antigens and proteins naturally present on platelet membranes. This is unlike other efforts, which synthesize platelet mimics that replicate one or two surface proteins of the platelet membrane."
which can result in toxicity. SNAS naturally go to the right place in cells. They enter via the endosome,
There has been considerable recent work on using magnetite to clean up toxic metals. For example, magnetite can reduce the toxic form of chromium, chromium VI, to the less toxic chromium (III),
which can then be incorporated into a magnetite crystal. The fact that this magnetite may then be exposed to these reducing bacteria could potentially enhance its remediation capacity.
Current coatings to prevent fouling by marine organisms include toxic chemicals, and become ineffective after a short time
The research team separated the hard-to-kill stem cells from the general glioblastoma population by attracting the stem cells to a microchip coated with antibodies.
whether we could isolate these types of toxic cells from the other brain tumor cells, while developing new imaging tools at the single-cell level to visualize the course of therapies needed to eradicate these cells,
The drug-loaded nanocapsule is coated with an antibody that specifically targets activated platelets, the cells that form blood clots,
it's also the improvement in targeting and reduction in toxicity, which is just icing on the cake.
which are highly toxic to fish and other aquatic organisms, in water. Lead researcher Dr Zo Waller, from UEA's school of Pharmacy, said:"
researchers at The University of Texas at Austin have created a new flame retardant to replace commercial additives that are often toxic
these chemicals can migrate out of the products over time, releasing toxic substances into the air and environment.
this question of toxicity immediately goes away, "Ellison said.""We believe polydopamine could cheaply and easily replace the flame retardants found in many of the products that we use every day,
#Detecting HIV diagnostic antibodies with DNA nanomachines Detecting HIV diagnostic antibodies with DNA nanomachines (Nanowerk News) New research may revolutionize the slow,
cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases such as rheumatoid arthritis and HIV.
"whose customized modifications enable it to recognize a specific target antibody. Their new approach, which they described this month in Angewandte Chemie("A Modular, DNA-Based Beacon for Single-Step Fluorescence Detection of Antibodies and Other Proteins"),
"promises to support the development of rapid, low-cost antibody detection at the point-of-care, eliminating the treatment initiation delays
and increasing healthcare costs associated with current techniques. New research may revolutionize the slow, cumbersome and expensive process of detecting the antibodies that can help with the diagnosis of infectious and autoimmune diseases such as rheumatoid arthritis and HIV.
An international team of researchers have designed and synthesized a nanometer scale DNA"machine "whose customized modifications enable it to recognize a specific target antibody.
Their new approach, which they described this month in Angewandte Chemie, promises to support the development of rapid,
low-cost antibody detection at the point-of-care, eliminating the treatment initiation delays and increasing healthcare costs associated with current techniques.
The light-generating DNA antibody detecting nanomachine is illustrated here in action, bound to an antibody.
Marco Tripodi) The binding of the antibody to the DNA machine causes a structural change (or switch),
and is rapid-acting within five minutes-enabling the targeted antibodies to be detected easily, even in complex clinical samples such as blood serum."
so that it can detect a huge range of antibodies, this makes our platform adaptable for many different diseases"."
""Our modular platform provides significant advantages over existing methods for the detection of antibodies,"added Prof.
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