or understand how cancer cells are organized in a metastasizing tumor or how immune cells are configured in an autoimmune attack you have to look at a large piece of tissue with nanoscale precision he says.
While Boyden's team is focused on the brain other possible applications for this technique include studying tumor metastasis
and angiogenesis (growth of blood vessels to nourish a tumor) or visualizing how immune cells attack specific organs during autoimmune disease e
in order to cope with unpredictable episodes of infection injury and tumor formation. The immune system has to think on its feet said Davis senior author of the new study which will be published Jan 15 in Cell.
In mice prone to develop benign skin tumors-papillomas-the activation of Fra-2 reduced skin tumor burden.
but studies have shown that disrupting circadian rhythms in mice causes tumors to grow faster, and one of the things the clock does is set restrictions on
Because of its accuracy, it could also better distinguish between benign lung tumors that do not pose a threat
. associate professor in the Tumor Microenvironment and Metastasis Program at The Wistar Institute and lead author of the study."
since they are often found in tumor cells that circulate in the blood. After analyzing 116 different CTAS,
and accumulate at the tumor site. However, tests of these nanodrugs show that only between one and 10 percent of the drugs are delivered to the tumor site
with the majority of the remainder being diverted to the liver and spleen.''The body's immune system, especially the liver and spleen, has been one of the biggest stumbling blocks in developing nanoscale chemotherapy drug delivery systems,
The researchers believe that this increased availability will allow more of the drug to reach the tumor site,
#Disrupting tumor cell'microenvironment'suggests a new way to treat a prevalent childhood leukemia Researchers at NYU Langone Medical center
and tumors were smaller than in similar mice that retained CXCL12 production. Deletion of the CXCR4 gene led to sustained T-ALL remission within a month in similar mice,
'In the long run, we anticipate that the ability to drive immune reaction ex vivo at controllable rates grants us the ability to reproduce immunological events with tunable parameters for better mechanistic understanding of B cell development and generation of B cell tumors,
Most importantly, they also found that these stem cells can give rise to colonic tumors and sustain their growth.
they also found that these stem cells can give rise to colonic tumors and sustain their growth.
and sustain tumors, telling us that our cancer therapy needs to target more than one stem cell pool.'
and efforts are ongoing to expand this to tumors beyond kidney cancer, "says Dr. Ho.
such as interferons, might reduce tumor progression. Also, transferring healthy microbiota or a group of'good'bacteria to patients with colorectal cancer at the early stage of disease may prolong survival,
And a study by other researchers had found that more than half of small bowel tumors had AIM2 mutations.
showed significantly more tumors than normal mice. The scientists'studies also showed that AIM2 played a role independent of its immune role,
The scientists found a striking reduction in colon tumors in the AIM2-deficient mice and an increase in tumors in the normal mice.'
#New mechanism that regulates tumor initiation, invasion in skin basal cell carcinoma Researchers at the Université libre de Bruxelles,
directly controls skin cancer formation by regulating the expansion of tumor initiating cells and the invasive properties of cancer cells.
and is maintained in invasive tumors. Deletion of Sox9 prevents skin cancer formation demonstrating the essential role of Sox9 during tumorigenesis
"It was really exciting to see that the deletion of only one gene was sufficient to completely prevent tumor formation.
as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation
cell adhesion and cytoskeleton dynamics required for tumor invasion. These results have important implications for the development of novel strategies to block tumor formation and invasion in the most frequent cancer in humans."
"Given that the majority of human cancers express Sox9, it is likely that the results of this study will be relevant for other cancers in humans
and will help to define new strategies to prevent cancer formation and block tumor invasion"comments Cédric Blanpain, the last and corresponding author of this study.
#Discovery could lead to personalized colon cancer treatment approach A UNC Lineberger Comprehensive Cancer Center discovery of just how a certain tumor suppressor molecule works to prevent tumor growth could lead to a personalized treatment
the researchers reported that the tumor-suppressing protein AIM2, or Absent in Melanoma 2, helps prevent colon cancer by restricting a signaling molecule called Akt.
With this finding, the researchers believe theye found a possible drug target for colon cancer patients who lack the tumor suppressor AIM2. everal studies
and clinical evidence suggest AIM2 functions as a tumor suppressor, but until now, wee had very little direct evidence to explains how this occurs,
And in mouse models lacking AIM2, the researchers found that they had smaller tumors and precancerous colon polyps when blocked Akt.
and eventually study other tumor types including lung, colorectal and breast cancers s
#Omnidirectional free space wireless charging of multiple wireless devices Scientists have made great strides in wireless-power transfer development.
Advances in the understanding of the molecular processes that cause these tumors has resulted in therapies aimed at delivering specific genes into tumors--genes that make proteins to kill
or suppress the growth of the tumor. Currently this approach relies heavily on using viruses to deliver the anti-tumor genes into the target cancer cells.
Unfortunately, viral delivery poses significant safety risks including toxicity, activation of the patient's immune system against the virus,
and the possibility of the virus itself encouraging tumors to develop.""Efforts to treat glioma with traditional drug
Because it is important that the nanoparticles spread throughout the entire tumor, they were infused into the rat gliomas using convection-enhanced delivery (CED).
The method involves injection into the tumor and the application of a pressure gradient, which efficiently disperses the nanoparticles throughout the tumors.
To test the tumor-killing ability of the system, the tumor-bearing rats were given systemic administration of ganciclovir for two days,
then CED was used to infuse the HSVTK-encoding nanoparticles into the rat gliomas, and systemic ganciclovir treatment continued for eight more days.
The treatment resulted in shrinkage of the tumors and a significant increase in survival when compared with control glioma-bearing animals that did not receive the combination treatment."
"The results provide the first demonstration of a successful non-viral nanomedicine method for HSVTK/ganciclovir treatment of brain cancer,"stated Green."
--which could broaden the use of the therapy for a wide range of solid tumors and systemic cancers s
but most tumors only become lethal once they metastasize or spread from their first location to sites throughout the body.
The tumor undergoes a number of changes to its DNA--mutations--that make the cells more mobile
such as the bone, the lungs, the liver or other organs, where new tumors start to grow.
in part because it would repair the usually lethal damage to tumors caused by radiation therapy and other treatments.
And in mice with aggressive human tumors, an inhibitor of DNA-PKCS reduced overall tumor burden in metastatic sites.
and that high levels of DNA-PKCS could predict which early stage tumors may go on to metastasize,
this new trial will provide some insight into the effect of DNAP-PKCS inhibitors as anti-tumor agents.
In parallel, using this kinase as a marker of severe disease may also help identify patients whose tumors will develop into aggressive metastatic disease,
"Given the role of DNA-PKCS in DNA repair as well as control of tumor metastasis, there will be challenges in clinical implementation,
liquid biopsy effectively unmasked different tumor-related mutations. More specifically, in a subgroup of 41 patients who had received previously anti-EGFR therapy,
and the results show the former (BEAMING technology) obtain more data on tumor mutation throughout the course of the disease,
enabling us to better target therapy to the specificities of patient's tumor; this could have a considerable impact on clinical practice,
The majority of clinical studies published on the use of DNA in blood to determine tumor genotype,
Liquid biopsy, also known as a blood-based biomarker test, is a fast, simple method for detecting RAS (KRAS and NAS) mutation status in tumors
and deliver targeted therapies tailored to the particularities of each tumor for an increasing number of patients.
for example, the possibility that not all tumors release enough DNA into the blood for it to be detected,
as well as the difficulty of assigning a particular genotype for each particular tumor in patients with multiple metastases,
#Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize.
and build that into a nanoscale carrier that can seek out a tumor and deliver a payload of drug,
The shell fragments form a ragged mesh that holds the drug molecules near the tumor.
builds on his group's earlier sucess using a similar strategy to mark tumors for both diagnosis and precise surgical removal.
That means the drug was inactivated as it flowed through the circulatory system until it reached the tumor.
in a test in mice with grafted in fibrosarcoma tumors. In additional preliminary tests, Callmann and colleagues were able to halt the growth of the tumors for a least two weeks,
using a single lower dose of the drug. In mice treated with the nanoparticles coated with peptides that are impervious to MMPS or given saline,
the tumors grew to lethal sizes within that time. Gianneschi says they will broaden their approach to create delivery systems for other diagnostic and therapeutic molecules."
Interleukin 6 (IL-6) is an important cytokine that controls the cell survival and tumor growth.
Researchers from BUSM and the University of Cyprus compared the markers on the surface of the cancer cells to gene expression profile of breast tumors deposited by researchers in international public databases
they found that the tumor growth was significantly slower in models. Furthermore, models that received the altered cancer cells had very small or no metastasis to the lungs,
When exposed to foreign bacteria, viruses, tumors, and transplant tissue, the body stirs up a torrent of immune activity:
and classify tumors. It pairs with a smartphone via bluetooth. The scanning results appear on the phone screen.
but replicates when injected into lesions or tumors, and then stimulates the body immune system to fight the cancer. he results from this study are said amazing,
The study found that injection of the two inhibitors shrunk tumors in the majority of patients with advanced melanoma.
#Petri dish tumor test could personalize drug therapy for cancer patients In a highly successful, first-of-its-kind endeavor,
which involves co-culturing multiple myeloma tumor cells with their surrounding nontumor cells, all from the same patient, in a microscale petri dish.
The researchers then treated the tumor cells with bortezomib, a drug commonly used in multiple myeloma therapy.
The fundamental idea behind the research was to focus on everything surrounding a tumor not just the tumor itself.
These surroundings can include bone marrow stromal cells, macrophages and other immune cells, all of which represent an integral part of the tumor environment.
By including these components in a microfluidic petri dish a device developed by Beebe and Miyamoto lab a few years ago the researchersability to accurately gauge results increased dramatically.
we anticipate that the ability to drive immune reaction ex vivo at controllable rates grants us the ability to reproduce immunological events with tunable parameters for better mechanistic understanding of B cell development and generation of B cell tumors,
When removing a tumor, for example, neurosurgeons walk a tightrope as they try to take out as much of the cancer as possible
I in agony when I taking out a tumor. If I take out too little the cancer could come back;
While yet other mass spectrometry-based techniques such as desorption electrospray ionization and rapid evaporative ionization mass spectrometry are being evaluated for classifying tumors and providing prognostic information,
The work raises the possibility that targeted cancer drugs that lower levels of the protein could suppress tumor growth without affecting healthy cells.
a UCSF graduate student in the Biomedical sciences Program. his represents a new and exciting finding in regard to how we might target the development of tumors.
especially since previous research has shown that eif4e is present at abnormally high levels in tumor cells. ancer cells rely on increases in protein synthesis as a critical means for sustaining their growth and survival,
just as tumor cells do. But when the researchers introduced oncogenic Myc and Ras into cells in
they again observed that the potential of these cells to develop tumors was weakened significantly. The researchers found,
but it is our hope that this could one day be used to deliver drugs directly to spinal cord injuries, ulcerations, deep bone injuries or tumors,
#New approach holds promise for earlier, easier detection of colorectal cancer Caltech chemists develop a technique that could one day lead to early detection of tumors Chemists at Caltech
especially the development of tumors, if the process goes awry. When all is working well,
like suppress the growth of tumors or express proteins that repair damaged DNA, and that, in turn, can lead to cancer.
each composed of a colorectal tumor sample and an adjacent healthy tissue from the same patient.
NA Electrochemistry shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors, was supported by the National institutes of health a
#Risk of bowel cancer reduced by taking aspirin for Lynch syndrome patients An international study led by The University of Melbourne has confirmed that long-term regular taking of aspirin
#Tumor-suppressing gene lends insight to cancer treatment Cell duplication and growth is essential to sustaining life,
a known tumor-suppressor gene, has mutated or is absent, this delicate replication process derails and can lead to cancer development.
and growing evidence has shown that PTEN is a powerful tumor suppressor. Less clear, however, has been whether
as scientists have shown that using drugs to block PD-1 coaxes T cells to attack tumors.
one of many solid-tissue tumors that are expected to be a much higher hurdle for the field of cell-based immunotherapy.
which will kill an estimated 14,000 women in the U s. this year. he big question is, an you cross over to solid tumors?'
The cells will also zero in on a tumor cell target called MUC16 and they will carry a self-destruction switch that clinicians can trigger in case the cells get too aggressive, hit unintended targets,
Those modifications are meant to overcome some of the challenges solid tumors present, although Brentjens cautions not to expect the same results that CAR-T cells have shown so far in leukemia and lymphomaemission rates well above 50 percent.
and patients dream of the cells attacking solid tumors, which account for about 90 percent of all cancers.
The Sloan Kettering trial won be the first test of engineered T cells in solid tumors.
NVS), reported the cells showed no effect on the tumors. And Juno partner, Seattle Children Hospital, has started just a Phase 1 CAR-T trial for children with neuroblastoma,
Brentjens says by restricting the secretion of IL-12 to the area right around the tumor,
For example, people with a lot of tumor mass in their bodies might need to be monitored more closely.
< Back - Next >
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011