#3d bone marrow made from silk biomaterials successfully generates platelets (Nanowerk News) Researchers funded by the National Institute of Biomedical Imaging
Understanding and reproducing key features of bone marrow formationnd hence, the creation of blood cells and platelets in tissue culture for storage and later useould help in treatment of a variety of medical problems.
The researchers anticipate a wide range of applications, for example in portable electronics and in the medical world l
biotechnology and medical treatments. The study appears September 21 in Nature Materials("Sequence Heuristics To Encode Phase Behaviour In Intrinsically Disordered Protein Polymers"."
""The very simple design rules that we have discovered provide a powerful engineering tool for many biomedical
says James Collins, the Termeer Professor of Medical Engineering and Science in MIT Department of Biological engineering and Institute of Medical Engineering and Science (IMES).
That means the materials aren't durable enough for consumer electronics or biomedical devices.""Metallic materials often exhibit high cycle fatigue,
each requiring preclinical and clinical testing with live subjects. How many chemical agents more to try? Moving at such rate, will we find the cure during our lifetime?
This approach will eventually provide more effective preclinical selection of drug candidates for the subsequent long-term and expensive clinical trial.
Owing to the above-mentioned merits, SPR biosensing is an outstanding platform to boost technological progress in the areas of medicine and biotechnology.
Widespread introduction of this method into preclinical trials will completely change the pharmaceutical industry. With SPR sensors we just need to estimate the interaction between the drug and targets on the sensing surface,
However, the developed chip should go through a clinical trial for medical applications s
#Pioneering research develops new way to capture light-for the computers of tomorrow The key breakthrough will allow large quantities of data to be stored directly on an integrated optical chip,
Biomedical engineers are interested in recreating these developmental gradients in adults to aid the growth of new tissue in areas that have sustained damage.
IBIB goal is to help develop enabling technologies that could have big impacts on important medical problems,
noninvasive 3d biomedical imaging photonic chips aerospace photonics micromachines laser tweezing the process of using lasers to trap tiny particles.
which would enhance the effectiveness of medical interventions.""The key breakthrough underlying this new technology came by chance."
this novel device is very suitable for applications such as soft robotics, wearable consumer electronics, smart medical prosthetic devices,
which are utilised already increasingly for monitoring critical parameters in biomedical applications, especially for those that may come in contact with human skin
With the rapid advancement of healthcare and biomedical technologies as well as consumer electronics we are optimistic about new possibilities to commercialise our invention,
#Ultrafast lasers offer 3-D micropatterning of biocompatible hydrogels Tufts University biomedical engineers are using low energy,
The laser-based micropatterning represents a new approach to customized engineering of tissue and biomedical implants.
Virologists at Texas Biomedical Research Institute in San antonio prepared the viral samples for testing. The system combines two small chips, a microfluidic chip for sample preparation and an optofluidic chip for optical detection.
said co-author Michael Girardi, a professor of dermatology at Yale Medical school. n fact, the indirect damage was worse
and development of new medicines by greatly accelerating the computer-aided design of pharmaceutical compounds (and minimizing lengthy trial and error testing);
including cancer drug delivery and implantable biomedical devices. However the UT Austin team is thought to be one of the first to pursue the use of polydopamine as a flame retardant.
built its own neurological map of the office. The computer navigation system assists the robot in situations where it is lost in a new environment,
but when human proteins form amyloids they are associated usually with diseases especially neurodegenerative diseases such as Alzheimer, Parkinson,
which in turn has a wide range of applications from biomedical imaging to airport security. The next step for the research team is to present a proof-of-concept experimental realization of this scheme e
Nanotechnology, Biology and Medicine. While current HIV treatments involve pills that are taken daily, the new regimenslong-lasting effects suggest that HIV treatment could be administered perhaps once or twice per year.
Steel surgical tools can still carry microorganisms that cause deadly infections. Now researchers at the Harvard John A. Paulson School of engineering and Applied sciences (SEAS) have demonstrated a way to make steel stronger, safer and more durable.
and avenues for commercialization, including non-fouling medical tools and devices, such as implants and scalpels, nozzles for 3d printing and, potentially, larger-scale applications for buildings and marine vessels.
Medical steel devices are one of the material's most promising applications, said Philseok Kim,
and cofounder and vice president of technology AT SEAS spin-off SLIPS Technologies Inc."Because we show that this material successfully repels bacteria and blood, small medical implants,
#Researchers show how new hydrogel can facilitate microsurgery Skillful surgeons can do amazing things in extremely small places,
allowing surgeons to make an easier connection.""This would help in any type of surgery where you are trying to restore as many vessels as you can,
whether in a whole transplant or in damaged tissue from some kind of accident,"Nagy-Smith said."
The surgeon essentially has a third hand.""Tested with mice, whose femoral arteries are about 200 microns in diameter-four
and transplant surgeries and also could open up new possibilities in research h
#Artificial material mimics photosynthesis A Florida State university researcher has discovered an artificial material that mimics photosynthesis
a team of bioengineers at Rice university and surgeons at the University of Pennsylvania have created an implant with an intricate network of blood vessels that points toward a future of growing replacement tissues and organs for transplantation.
or weeks to grow in the lab prior to surgery. The new study was performed by a research team led by Jordan Miller, assistant professor of bioengineering at Rice,
and Pavan Atluri, assistant professor of surgery at Penn. The study showed that blood flowed normally through test constructs that were connected surgically to native blood vessels.
In this study, we are taking the first step toward applying an analogy from transplant surgery to 3-D printed constructs we make in the lab."Miller
"What a surgeon needs in order to do transplant surgery isn't just a mass of cells;
the surgeon needs a vessel inlet and an outlet that can be connected directly to arteries and veins,
"he said. Bioengineering graduate student Samantha Paulsen and research technician Anderson Ta worked together to develop a proof-of-concept construct--a small silicone gel about the size of a small candy gummy bear--using 3-D printing.
but they have some of the key features relevant for a transplant surgeon, "Miller said."
"Collaborating surgeons at Penn in Atluri's group connected the inlet and outlet of the engineered gel to a major artery in a small animal model.
"This study provides a first step toward developing a transplant model for tissue engineering where the surgeon can directly connect arteries to an engineered tissue,
"We have discovered that it is the plant equivalent of the nude mouse used in medical research.""
Their new approach created the first-ever flexible Fresnel zone plate microlenses with a wide field of view--a development that could allow everything from surgical scopes to security cameras to capture a broader perspective at a fraction of the size required by conventional lenses.
Their new approach created the first-ever flexible Fresnel zone plate microlenses with a wide field of view--a development that could allow everything from surgical scopes to security cameras to capture a broader perspective at a fraction of the size required by conventional lenses.
The enhanced limit of detection will allow biomedical and environment monitoring of important molecules at high sensitivity by SERS."
These brain-like structures offer the opportunity to reproduce more accurate 3d in vitro microstructures with applications ranging from cell behavior studies to improving our understanding of brain injuries and neurodegenerative diseases r
The buildup of brain waste chemicals may contribute to the development of Alzheimer disease and other neurological conditions.
Dr. Benveniste, Principal investigator and a Professor in the Departments of Anesthesiology and Radiology at Stony Brook University School of medicine, has used dynamic contrast MRI for several years to examine the glymphatic pathway in rodent models.
Assistant professor in the Departments of Anesthesiology and Radiology at Stony Brook developed the safe posture positions for the experiments.
which has implications not only for a range of neuropsychiatric disorders such as ADHD, eating disorders and anxiety disorders,
says John Essigmann, the William R. 1956) and Betsy P. Leitch Professor in Residence Professor of Chemistry, Toxicology and Biological engineering at MIT,
neuropathology or treatment prognosis. Thus far, the neuroscience of emotion has yielded many important results but no such indicators for emotional experiences.
A new study may have unlocked understanding of a mysterious part of the brain with implications for neurodegenerative conditions such as Alzheimer.
Glaucoma is a neurodegenerative disease where patients lose seemingly random patches of vision in each eye.
In the latest TVST paper, Refined Frequency Doubling Perimetry Analysis Reaffirms Central nervous system Control of Chronic Glaucomatous Neurodegeneration
which have neurodegenerative biology similar to glaucoma, may also be mediated actively by the brain. ur work has illustrated that the brain will not let us lose control of the same function on both sides of the brain
It seems likely that the same kind of protective mechanism will be at work with other neurodegenerative disorders,
if the brain regulates neurodegeneration that if the brain controls how it loses control then researchers will now be able to look into largely unexplored regulatory processes for opportunities to slow
The paired eyes and brain are reaffirmed to function as a unified system in the progressive age-related neurodegenerative condition chronic open angle glaucoma,
Given the extensive homology of this disorder with other age-related neurodegenerations, it is reasonable to assume that the brain will similarly resist simultaneous bilateral loss of paired functional zones in both hemispheres in diseases like
Glaucomatous eyes at all stages of the disease appear to provide a highly accessible paired-organ study model for developing therapeutics to optimize conservation of function in neurodegenerative disorders. efined Frequency Doubling Perimetry Analysis Reaffirms Central nervous system Control of Chronic
and Dr. Kaddour Bouazza-Marouf, Reader in Mechatronics in Medicine, said the device learns from its user,
This method was found to deliver medicine to the brain with few side effects. About one out of every hundred Norwegians develop schizophrenia or autism in the course of their lifetime.
Many psychiatric disorders such as autism, schizophrenia and bipolar disorder are characterised by poor social functioning. Oxytocin is a hormone that influences social behaviour
who have developed a new device designed to improve medicine delivery to the brain via the nose.
Medicine through the nose Because of oxytocin role in social behaviour, researchers have explored the possibility of administering the hormone for the treatment of mental illness.
Breathing helps Optinose uses a new technology to distribute medicine to the brain, making use of the user breath to propel medicine deep into the nasal cavity.
The device administers oxytocin high up into the patient nasal cavity. When the medicine is targeted deep inside the nose,
it enables brain delivery along nerve pathways from the uppermost part of the nasal cavity. Conventional nasal spray devices are suited not to consistently deliver medicine high up enough into the nose.
The device also expands the nasal cavity, facilitating nose-to-brain medicine delivery. As the user exhales into the device
this closes the soft palate and prevents the medicine from being lost down the throat. Since less medicine is lost along the way,
patients can take smaller doses and accordingly experience fewer side effects. May yield new treatments The next step in the research is to carry out the same tests on people with mental illness. e are now running tests in volunteers diagnosed with autism spectrum disorders,
says Dr Quintana. e hope that this research project is the first step in the development of a series of new medicines that may be of great help to more people with mental illness,
concludes Professor Andreassen o
#New Technology Enables Completely Paralyzed Man to Voluntarily Move His Legs Robotic step training and noninvasive spinal stimulation enable patient to take thousands of steps.
the man was aided by a novel noninvasive spinal stimulation technique that does not require surgery.
That earlier achievement is believed to be the first time people who are paralyzed completely have been able to relearn voluntary leg movements without surgery.
The research will be published by the IEEE Engineering in Medicine and Biology Society, the world largest society of biomedical engineers. t will be difficult to get people with complete paralysis to walk completely independently,
but even if they don accomplish that, the fact they can assist themselves in walking will greatly improve their overall health
and quality of life, said V. Reggie Edgerton, senior author of the research and a UCLA distinguished professor of integrative biology and physiology, neurobiology and neurosurgery.
Neurorecovery Technologies, a medical technology company Edgerton founded, designs and develops devices that help restore movement in patients with paralysis. The company provided the device used to stimulate the spinal cord in combination with the Ekso in this research.
which seek to develop closed-loop direct interfaces to the brain to restore function to individuals living with memory loss from traumatic brain injury or complex neuropsychiatric illness y
a UCLA professor of neurology and member of the Easton Laboratory for Neurodegenerative Disease Research. ecause the presentation varies from person to person,
#Researchers Identify Protein That Opens the Door to Cell Death Findings could aid development of novel therapeutics for conditions ranging from heart failure and stroke to cancer and neurodegeneration.
and the Center for Translational Medicine at Temple University School of medicine (TUSM), shows that the protein, spastic paraplegia 7 (SPG7), is the central component of the so-called permeability transition pore (PTP),
Dr. Madesh also explained that the new findings could aid the development of novel therapeutics for conditions ranging from heart failure and stroke to cancer and neurodegeneration all of
The study was published recently online ahead of print by the journal Biological Psychiatry. The molecule in question is known as a regulator of G protein signaling (RGS PROTEIN,
said Gargus, director of the Center for Autism Research & Translation and professor of pediatrics and physiology & biophysics. qually exciting,
Study results appear online in Translational Psychiatry, a Nature publication. Autism spectrum disorder is a range of complex neurodevelopmental disorders affecting 2 percent of U s. children.
such as the ER, are an emerging field in medicine, with several well-recognized neurological ailments linked to two other ones, the mitochondria and lysosomes.
The IP3R controls the release of calcium from the ER. In the brain, calcium is used to communicate information within and between neurons
#Liquid crystals Show Potential for Detecting Neurodegenerative Diseases Liquid crystals are familiar to most of us as the somewhat humdrum stuff used to make computer displays and TVS.
as detectors for the protein fibers implicated in the development of neurodegenerative diseases such as Alzheimer.
Amyloid fibrils are protein aggregates that are associated with the development of neurodegenerative diseases including Huntington disease, Parkinson, Alzheimer,
and Christopher J. Martyniuk of the Center for Environmental and Human Toxicology and Department of Physiological Sciences, UF Genetics Institute, University of Florida.
something that greatly complicates the work of neurosurgeons. On the other hand, the brain is the seat of natural vibrations created by the blood pulsating in the arteries and the circulating cerebrospinal fluid.
such as for analysing the development of neurodegenerative processes, the impact of a lesion from a trauma or tumour, response to treatment, etc.
and progression of disease, says senior author Katerina Akassoglou, Phd, a senior investigator at the Gladstone Institutes and professor of neurology at the University of California,
and brain macrophages, says Scott Zamvil, MD, Phd, a professor of neurology at the University of California,
Researchers from the Rowan University School of Osteopathic Medicine are nearing development of a blood test that can accurately detect the presence of Alzheimer disease,
People found to have preclinical disease can take steps to improve their vascular health, including watching their diet,
Detecting Alzheimer antibodies at the preclinical stage would give patients an opportunity to work with their physician to make lifestyle changes
Potentially, this early intervention could help those with preclinical Alzheimer avoid or delay the most devastating symptoms. s osteopathic physicians,
we constantly tell patients that a healthy lifestyle is the best medicine for preventing disease.
We also know that many people tune out messages about nutrition and exercise until a health crisis gets their attention,
DO, assistant professor of family medicine at Rowan University. can think of a single patient who wouldn take steps to prevent the progression of Alzheimer
#New Drug Delivery Technique Bypasses Blood-brain barrier Breakthrough could help countless patients with neurological conditions that are currently hard to treat.
Their findings, published in Neurosurgery, lend hope to patients around the world with neurological conditions that are difficult to treat due to a barrier mechanism that prevents approximately 98 percent of drugs from reaching the brain
and central nervous system. e are developing a platform that may eventually be used to deliver a variety of drugs to the brain,
Eye and Ear/Harvard Medical school. lthough we are currently looking at neurodegenerative disease, there is potential for the technology to be expanded to psychiatric diseases, chronic pain,
seizure disorders and many other conditions affecting the brain and nervous system down the road. Using nasal mucosal grafting,
because the therapy has been shown to delay and even reverse disease progression of Parkinson disease in preclinical models.
Nasal mucosal grafting is a technique regularly used in the ENT field to reconstruct the barrier around the brain after surgery to the skull base.
ENT surgeons commonly use endoscopic approaches to remove brain tumors through the nose by making a window through the blood-brain barrier to access the brain.
which represents part of the blood-brain barrier (B). After endoscopic skull base surgery (C), all of these layers are removed
surgeons may create a creen doorto allow for drug delivery to the brain and central nervous system. The technique has the potential to benefit a large population of patients with neurodegenerative disorders,
where there remains a specific unmet need for blood-brain penetrating therapeutic delivery strategies. e see this expanding beyond Parkinson disease,
including more neurological drugs. The company is owned privately. Doctors are increasingly turning to 3d printing to create customised implants for patients with rare conditions
The FDA held a workshop last year for medical manufacturers interested in the technology o
Designer tissue ach case that a surgeon would be presented with is going to be unique, says team member Miles Montgomery at the University of Toronto,
Shea devised the approach along with Jacqueline Jeruss, a breast cancer surgeon. Jeruss had noticed how common it was for her patientsfirst symptom to be breathlessness as the cancer had already spread to their lungs.
such as those who have had already surgery to remove a tumour and might experience a recurrence.
By contrast, the only stem-cell-based medicinal product that is currently approved for use in the EU a cornea treatment involves removing cells from each individual eye
and regulating their glucose levels (New england Journal of Medicine, doi. org/7s4). Type 1 diabetes is caused by destruction of beta cells in the pancreas that make insulin to control how much sugar circulates in the blood.
so they based the brain on detailed images of the professor grey matter. e could foresee a future in which, before brain surgery,
the surgeon 3d prints a brain out of hydrogel and then practises on it, says Angelini. hen the surgeon knows exactly how that surgery is going to happen. heye made,
I think, a significant advance, says Jennifer Lewis of Harvard. t a beautiful piece of work. One of the limitations, she says,
when a section of the skull has been removed during surgery. octors can only feel a few centimetres deep,
This can be useful before surgery he says: while a soft mass can be sucked swiftly away,
The discovery creates a potential new target for safer migraine medicines and adds weight to the theory that neurons,
says James Nicoll, a neuropathologist at the University of Southampton, UK. Aigner agrees he will start by testing the drug in people with Parkinson disease,
says Oren Etzioni, director of AI2. f youe a medical researcher, you could ask hat the latest on these drug interactions?
or technique that they could use, in a medical case, to save somebody life. AI2 is not the only organisation intent on digitising
these modified yeast strains should make it much easier and cheaper to manufacture new painkilling medicine
these modified yeast strains should make it much easier and cheaper to manufacture new painkilling medicine
where there's a terrible shortage of pain medicine, Smolke says. Still, the genetically modified yeast strains have triggered a heated debate about how to regulate these organisms and the possibility of"home-brewing morphine.""
Surgeons at Salamanca University Hospital reported the man's case and how they made the prosthesis last month in the European Journal of Cardio-Thoracic Surgery.
Engineers at Anatomics in Melbourne, Australia, custom-designed the device using CT SCANS of the man's chest.
Surgeons typically use a combination of flat plates, bars and mesh to build an artificial rib cage and sternum for patients.
The 3-D printing technology allowed the surgeons to create an implant that"fitted like glove"in the man's chest, Dr. Jose Aranda
But the surgical team admits that such a complex prosthesis is probably helpful only for extreme cases,
The new imaging method could make future medical applications more cost-effective and space-efficient than is possible with today technologies.
The researchers say that their technology is articularly interesting for medical applications as it can distinguish between differences in tissue density.
and potentially production of other products derived from aromatic amino acids Martin further said their work could be used effectively in a number of areas including plant and microbe engineering, medicinal plant natural products,
The researchers also hope that the similar technique can be used to manufacture other compounds that form the basis of many medicines a
The findings could help identify ways to repair damaged neural connections in patients with spinal cord injuries or neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), also known as Lou gehrig's disease.
Funding for the work came from the National institutes of health, Howard Hughes Medical Institute, Christopher and Dana Reeve Foundation, Sol Goldman Trust and Marshall Heritage Foundation a
#UV Catheter Plugs Holes in Hearts With help from UV light, a new catheter device could provide a way to repair defects in hearts and other organs without surgery.
"said Dr. Pedro del Nido, chief of cardiac surgery at Boston Children's Hospital. The catheter is inserted through a vein in the neck or groin and directed to the area of the defect.
The french company Gecko Biomedical, of which Karp is a founder, plans to test the adhesive in humans later this year r
#Antibiotic-Resistant Bacteria Are No Match For Medieval Potion Bloodletting, mercury cures, holes drilled in the headany ancient medical remedies seem ill-advised based on our modern understanding of medicine.
But researchers recently found that a thousand-year-old Anglo-saxon treatment for eye infections works as an antibiotic against one of today most notorious bacteria, Methicillin-resistant Staphylococcus aureus (MRSA.
and is one of the earliest known medical textbooks. The researchers prepared four batches of the recipe,
#Glowing Tumor Paint Shows Surgeons Where To Cut Brain surgery is complicated notoriously. Before surgeons go in to remove a tumor,
they study the size and location of the tumor. But once theye in, they have to rely on their fingers
so the surgeons had to remove a piece of the tissue before shining a light on it.
Ideally, doctors wouldn be using surgery at all to eliminate tumors--it still a rudetechnique, as one researcher said.
But while surgery is still a standard treatment, tumor paint could help surgeons be much more precise m
#A 3d-Printed, Battery-Powered Rocket engine Nothing demonstrates engineering prowess and technical knowhow quite like rocket science.
Liu hopes that his invention would one day be used to build shapeshifting robots to repair pipelines and delivery medicine inside blood vessels.
dubbed Tommy John surgery after the first player to get it, in 1974. Solution: During spring training this year, more than 10 MLB teams began using the Motus mthrow motion-tracking system to keep tabs on pitchersarm health.
The Pitch Bryan Christie Design After Tommy John surgery pitchers are out of rotation for an average of one year
And that figure, from a 2011 Institute of Medicine report, doesn even count kids in pain, veterans with devastating war injuries,
like morphine or codeine, are important for medical purposes. The drugs have been around for millennia
Material that heals itself in the presence of water could extend the usability of biomedical implants
But they note that medical procedures like surgery or blood transfusions could play a role in transmitting prions,
as a spokesperson from The british Department of health points out, a small study of eight patients isn yet cause for alarmut the researchers hope to investigate how prions could be transmitted in a medical setting in the near future e
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