| Amnesia (8) |  |
| Anorexia (5) | |
| Anxiety (61) | |
| Ataxia (18) | |
| Autism (210) | |
| Delusional disorder (9) | |
| Dementia (87) | |
| Hallucination (11) | |
| Mania (51) | |
| Mental disorder (32) | |
| Multiple sclerosis (75) | |
| Paranoia (7) | |
| Phobia (5) | |
| Psychosis (9) | |
| Schizophrenia (137) | |
| Speech disorder (7) | |
| Stress (299) | |
a leading journal in the field of developmental biology, open up new avenues for design of drugs for ataxia, a motor coordination disorder.
called BNIP-H, was linked first to Cayman ataxia, a rare genetic disorder affecting a region of the brain involved in motor control and
The study also provides the first experimental data solidifying the link between dysfunctional cholinergic (acetylcholine) secretion and Cayman ataxia.
The researchers showed that a BNIP-H mutant associated with Cayman ataxia caused defects in the transport of the ACL enzyme.
Furthermore, they could also reproduce motor dysfunctions of Cayman ataxia in zebrafish by knocking down BNIP-H, ACL or Chat enzymes.
suggesting that the loss of acetylcholine secretion resulting from BNIP-H mutation could explain some of the symptoms of Cayman ataxia.
"We established the first ACL-based ataxia model in the zebrafish that recapitulates the ataxic phenotype seen in human patients.
cellular and organism levels on how defects in ACL trafficking impairs cholinergic signalling that leads to the development of ataxia."
and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
a journal in the field of developmental biology, open up new avenues for design of drugs for ataxia, a motor coordination disorder.
called BNIP-H, was linked first to Cayman ataxia, a rare genetic disorder affecting a region of the brain involved in motor control and
The study also provides the first experimental data solidifying the link between dysfunctional cholinergic (acetylcholine) secretion and Cayman ataxia.
The researchers showed that a BNIP-H mutant associated with Cayman ataxia caused defects in the transport of the ACL enzyme.
Furthermore, they could also reproduce motor dysfunctions of Cayman ataxia in zebrafish by knocking down BNIP-H, ACL or Chat enzymes.
suggesting that the loss of acetylcholine secretion resulting from BNIP-H mutation could explain some of the symptoms of Cayman ataxia.
"We established the first ACL-based ataxia model in the zebrafish that recapitulates the ataxic phenotype seen in human patients.
cellular and organism levels on how defects in ACL trafficking impairs cholinergic signalling that leads to the development of ataxia."
and may lead to new treatments that involve BNIP-H."Our findings could provide new direction to better understand causes of cholinergic-related diseases, such as Alzheimer's disease, Down's syndrome, ataxia and schizophrenia.
< Back - Next >
Overtext Web Module V3.0 Alpha
Copyright Semantic-Knowledge, 1994-2011