The study was published online in Applied and Environmental microbiology, a journal of the American Society for Microbiology."
hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.
hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.
hepatitis and herpes. Researchers from Moscow Institute of Physics and Technology (MIPT) developed the ultracompact nanomechanical sensor for analysing the chemical composition of substances and detecting biological objects.
especially those caused externally,"said Hu Ping, a cell biologist with the Shanghai Institute for Biological science at the Chinese Academy of Sciences."
such as mutations that could lead to tumours. Such trials are crucial as safety is of paramount importance.
"said Yingfu Li, a professor in the Departments of Biochemistry and Biomedical sciences, Chemistry and Chemical Biology."
"This discovery was made possible by using 30 years of data and biologic specimens. Rappocciolo and her colleagues searched for patterns in gene expression,
Understanding leptospira's mutation, when in contact with aquatic organisms, is of greater significance for Mumbai,
The mutation study, published in a Federation of European Microbiological Studies journal in May, was a wake-up call for public health experts to find better ways to tame the bacteria.
or through cuts and abrasions,"said Dr Jayanti Shastri, head of microbiology at BYL Nair Hospital.
and are compared often to the biological structure of cartilage. While the development of the 3d printable hydrogels is certainly a breakthrough for Zhao and the rest of the team,
#MEDPRIN 3d prints world first biological meningioma Redura for use in brain surgery While 3d bioprinting innovations sound lifesaving and revolutionary, most are still years away from impacting ordinary
Called MEDPRIN, they have developed the world first 3d printed biological meningioma called Redura a replica of tissue covering the brain
they are not biological and have a tendency to disrupt a patient life-as most artificial meningioma layers contain metal parts
this 3d printed biological Redura doesn suffer from these problems, but instead closely resembles the existing membrane and a patient autologous cells.
the machine sprays out a fiber-like ink onto biological paper that simulates the collagen structures found in body.
and clinical resources to push 3d printing from biological tissue reconstruction all the way up to 3d printing of organ regeneration.
The mobile platform has been tested successfully in a clinical microbiology laboratory, comparing 571 patient samples to FDA-approved samples of mumps, measles,
and Omai Garner, associate director of clinical microbiology for the UCLA Health System, and written by UCLA undergraduate Brandon Berg (the study first author) manages to shrink this work down to the size
The FDA-approved well-plate readers used in clinical labs today were compared with the team handheld smartphone diagnostic in a UCLA clinical microbiology laboratory.
thus inducing greater biological damage. In this study, the authors analysed the spectra of secondary electrons emitted from a carbon nanoparticle composed of fullerite,
Some of the examples comprise materials that deliver biomolecules, rotate light, or control the flow of energy.
The team employed cryo-electron microscopy, also known as CRYO EM, to observe the particles and origami frames. This work was headed by Huilin Li, Brookhaven Lab and Stony Brook University biologist,
and Tong Wang, the other lead co-author of the paper and who also works with Li in the Biosciences department of Brookhaven.
CRYO EM preserves samples in their near-native states and provides close to nanometer resolution. We show that CRYO EM can be applied successfully to probe the 3d structure of DNA NANOPARTICLE clusters,
Wang said. The DOE Office of Science supported the study. DOE Office of Science supports the Brookhaven National Laboratory.
which also included Martha Grover from Georgia Tech School of Chemical & Biomolecular engineering, has used so far the solvent to assemble three structures,
The project goal is to develop new tools to elucidate the mechanism of action of a threat agent, drug, biologic or chemical on living cells within 30 days from exposure.
96 spot, target plate, suitable for simple and complex biological mixtures, and compatible with most standard MALDI-MS instrument systems.
"A new reliable biological standard is particularly attractive to the electron microscopy community as it has the potential to offer a cost effective solution for high-resolution imaging."
In their setup, a sphere was placed on one of the prongs--in a biological system
"Future work for Yabuno and his colleagues involves using the cantilevers to obtain high-accuracy quantitative measurements of biological samples such as human cells and DNA in liquid media d
and other biological parts. n the biological domain, there are various molecules and atoms in contact with one another, sliding along like biomolecular motors,
as a result of friction or lack of friction, Gangloff says. o this intuition for how to arrange atoms so as to minimize
and related impact of their novel method propels a huge variety of research fields investigating effects relevant from raft tectonics down to biological systems
which is still the gold standard in the health care industry for making a definitive diagnosis. Also routinely used today is a newer method for rapidly identifying bacteria based on a DNA-analysis technique called quantitative polymerase chain reaction (qpcr),
"This opens up a completely new frontier where we can explore the interface between electronic structures and biology.
but no one has addressed this issue-the electronics/cellular interface-at the level at which biology works."
"The idea of merging the biological with the electronic is not a new one for Lieber.
a process common to delivery of many species in biology and medicine-you could go to the doctor
"The ability to precisely control droplets using fluidic computation could have a number of applications in high-throughput biology and chemistry,
Dmitry Fedyanin and Yury Stebunov, have developed an ultracompact highly sensitive nanomechanical sensor for analyzing the chemical composition of substances and detecting biological objects,
researchers make it react with specific substances or even biological objects. If you place antibodies to certain viruses on the cantilever,
and its mission is to seek nanotechnology solutions to challenges in the fields of biology, energy or technology.
Researchers in Sykes'lab are now assessing precisely how the low energy electrons travel through biological fluids.
The human body is composed of chiral biomolecules. Many other biological objects are composed also of these chiral biomolecules.
In these compounds, the'left'form may be significantly different from the'right'form. Among these forms, usually one form is beneficial,
"said Dr. Carmen Gomes, Agrilife Research engineer with the Texas A&m University department of biological and agricultural engineering, College Station.
"I do the biological and polymer engineering; he does the electrochemistry and nanostructures, "she said.
As for the biological component, Gomes said she is using"nanobrushes"specially designed to grab particular bacteria.
builds on recent research by the same team that previously identified a fat-and-sugar molecule called GSL as the chief culprit behind a range of biological glitches that affect the body's ability to properly use, transport
and drug resistance is caused by mutations that cripple these transporters. Jose Garcia-Salcedo, from the Instituto de Investigacion Biosanitaria in Granada, Spain,
most importantly, circumvents drug resistance in a cell line that is resistant as a result of mutations in the transporter that mediates drug uptake.
and circumventing resistance mechanisms caused by mutations in surface transporters.""The implication of this proof-of-concept study of a novel technology for reversing transporter-related drug resistance,
or'CRYO EM'-imaging samples frozen to-180oc-to show the proteasome complex in such extraordinary detail that they could view a prototype drug bound to its active sites.
The research could help other scientists to use CRYO EM in structure-based drug design studies-in which researchers build the best possible drugs starting from a molecule which already binds to the active site of a target protein.
CRYO EM offers the opportunity to study protein complexes in conditions closer to those in the human body.
The finding was made by a team led by Dr Stephen Royle, associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school.
s a cell biologist you dream of finding a new structure in cells but it so unlikely.
award-winning scientists and pioneering professionals. arwick Medical school division of biomedical cell biology carries out fundamental molecular and cellular research into biomedical problems.
Without a molecular understanding of the underlying cell biology, intelligent directed therapeutic intervention is impossible. The division research focuses on fundamental cell biology processes such as cell division and intracellular communication.
Source: http://www2. warwick. ac. uk m
#Scientists Discover New Chemical reaction Pathway on Titanium dioxide The reaction mechanism, reported in ACS Nano, involves the application of an electric field that narrows the width of the reaction barrier,
Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State. The nanoparticles infused with silver ions were utilized to attack Pseudomonas aeruginosa, disease-causing bacteria;
#New Multispectral Microscope for Studying Impact of Experimental Drugs on Biological Samples This is the largest such microscopic image ever created.
This level of multicolor detail is essential for studying the impact of experimental drugs on biological samples
are present at each point in a single biological sample. harmaceutical research is awash with cutting-edge equipment that tries to image
and chemical processes that are taking place within a biological sample. This is essential for pharmaceutical research particularly cancer research--to observe how cells
and observe and study the biological and medical significance of RNA misregulation. Details will be published the week of July 20 in the journal Proceedings of the National Academy of Sciences (PNAS.
In particular, materials that mimic biological adsorbents like coral have potentially huge applications.""The researchers tested the coral-like nanoplates on removing mercury from water.
"We hope our work provides inspiration for more research into the development of materials that mimic biological organisms
and Biochemistry and the School of Chemical and Biomolecular engineering at Georgia Tech. e have made hollow nanocages of platinum with walls as thin as a few atomic layers
which will allow sensors to be incorporated into electronic apparel for measuring biological data, including heart rate and muscle contraction.
environmental monitoring, and chemical, biological, radiological, nuclear, and explosives (CBRNE) detection. For more information, go to FLIR web site at www. FLIR. com o
#Novel Synthetic Biosensor Glows in Response to Conditions that Mimic TB Infection Robert Abramovitch, an MSU microbiologist,
The findings, published in Nature Chemical Biology, raise promise for medicine but also concerns about"home-brewed"illegal drugs.
Prof Paul Freemont, one of the directors of the Centre for Synthetic biology and Innovation at Imperial College London, said:"
A team of chemists and biologists at the Institute of Transformative Biomolecules (ITBM), Nagoya University have succeeded in finding new molecules that change the circadian rhythm in mammals by applying synthetic chemistry methods,
Disruption of the circadian rhythm by genetic mutations and environmental factors such as jet lag, may lead to sleep disorders,
and worked closely with the biologists at ITBM to synthesize molecules for studying structure-activity relationships (SARS)."Through SAR studies on the molecular derivatives of KL001,
"says Takashi Yoshimura, an animal biologist and professor at ITBM, who also led this research from a biological perspective."
"It was found that the carbazole moiety was critical for rhythm-changing activity and that the substituents on the heteroaromatic ring are responsible for tuning the rhythm lengthening/shortening activities,
This is my first research outcome from the center's interdisciplinary collaboration between chemists and biologists,
and animal/plant biologists from different research groups work in the same lab space.""We hope we can make further use of synthetic chemistry to make bioactive molecules that can control the circadian rhythm of animals and gain further insight into the circadian clock mechanism,
These methods will help researchers determine which specific aspects of our biology are inherited, and uncover new insights into the genetics behind our countless biological processes."
Peter Facchini, professor in biological sciences, Jill Hagel, research associate, and Scott Farrow, Phd student. Many people who live in developing countries do not have access to the pain relief that comes from morphine or other analgesics.
"The findings were published July 1 in Nature Chemical Biology, and detail the missing step to morphine biosynthesis. Next steps Facchini says the isolation of this gene,
among many other things, is a key step toward the reassembly of the pathway to morphine in microorganisms such as yeast."
codeine and oxycodone,"says Facchini, professor of biological sciences in the Faculty of science and an internationally recognized expert on the opium poppy."
It was observed by a team of researchers including Gilles Hickson, an assistant professor at the University of Montreal's Department of Pathology and Cell biology and researcher at the CHU Sainte-Justine Research Centre, his assistant Silvana Jananji, in collaboration with Nelio
and Sergey Lekomtsev, a postdoc, working in the group led by Buzz Baum of the MRC Laboratory for Molecular Cell biology at University college London.
This is what makes fruit flies such a powerful system for helping us to understand human biology.""When chromosomes are segregated,
who has devoted the last 15 years of his research life to cell biology. In fact, all cancers are unchecked characterised by cell division,
"This spatial differentiation happens in biology naturally, but we demonstrated this process in vitro, "said study lead author Zhen Ma, a UC Berkeley postdoctoral researcher in bioengineering."
Dean of the University of Leeds'Faculty of Biological sciences and Professor of Mechanistic Biology, said:"
Dr Zahra Timsah, University Academic Fellow at the University of Leeds'School of Molecular and Cellular biology,,
"Previous research findings have emphasised the roots of cancer in genetic mutation. Some studies have pointed to cancers that occur without genetic causes,
"The implications for liver biology and drug discovery are said quite staggering Prof. Oren Shibolet, Head of the Liver Unit at the Tel-aviv Sourasky Medical center, who was involved not in this study."
but they also found ten new mutations in PRDM12 gene. The gene was known already to be involved in the modification of histones,
#Study paves way for genetics-first approach to brain cancer treatment Two US studies have identified specific genetic mutations in gliomas
Using previous studies into tumour biology, three mutations were identified in patients with gliomas. Tumours taken from glioma patients were scored as positive or negative for these mutations,
which led to the creation of five categories of mutation combinations. The genetic profiles of the tumours were associated then with patient age, prognosis and the response of the tumour type to different treatments.
For example tumours with one genetic profile were shown to grow slowly, and respond well to drug treatment,
therefore patients with this tumour type are good candidates for treatment by chemotherapy only. A second tumour type was shown to respond poorly to chemotherapy only,
'Both studies can justifiably claim that molecular classification captures the biologic features of glioma variants better than does histopathological evaluation,
'Instead of starting from genetics, we've started with the biology of the disorder itself to try to get a window into the genome,
According to a recent review in Nature Materials making one billion human pluripotent stem cells with a polymeric substrate is ten to 15 times cheaper than using a biological equivalent like Synthemax,
According to a recent review in Nature Materials making one billion human pluripotent stem cells with a polymeric substrate is ten to 15 times cheaper than using a biological equivalent like Synthemax
#Building a Better Microscope to See at the Atomic Level One of the more famous images in biology is known as"Photo 51,
One of the more famous images in biology is known as"Photo 51, "an image of DNA that chemist Rosalind Franklin and Raymond Gosling created in 1952 by shooting X-rays through fibers of DNA
Yet biologists are interested particularly in these membrane proteins because the membrane is the cell dock, its security checkpoint, its mailbox.
biologists need to zoom in to the atomic level. The proteinsresistance to crystallization, therefore, left scientists in a bind.
or CRYO EM, the technique had largely been written off as useless for determining the structure of very small proteins.
and other institutions have made CRYO EM a key tool in structural biology. ryo-EM has made this marked jump in the last three or four years in terms of resolution,
to use CRYO EM to visualize the structure of the body receptors that sense the spiciness of chili peppers and, in work reported last month, wasabi.
you can make connections between the biology and chemistry, and it also provides capability for drug discovery
who worked with Cheng to create better cameras and software for CRYO EM. o it really a huge change in what possible. etter Camera, Better Picture Yet for a long time,
scientists didn believe electron microscopy would be useful for imaging proteins and other biological samples at all.
The problem was that electron microscopes work by shooting electrons at the speed of light through a biological sample suspended in a vacuum;
this process often destroyed the raw biological samples researchers were trying to see. Then in the 1970s and 1980s, researchers at Heidelberg European Molecular biology Laboratory and Lawrence Berkeley National Laboratory developed a way to protect samples
they rapidly freeze the purified biological samples in a very thin layer of liquid. Yet even when frozen at around-300°F,
Another challenge was that earlier digital cameras used in CRYO EM detected light not electrons. So when the electron passed through the sample the signal had to be translated into light signals,
CRYO EM had previously been used to examine larger structures, like ribosomes and viruses, but this was the first membrane protein to
who does CRYO EM research at HHMI Janelia Research Campus, In virginia. Earlier this year, Cheng and Julius determined the structure of another key protein receptor,
for sure, said Cheng. his opens up tremendous opportunities for the field to tackle many challenging problems in structural biology.
The resolution of CRYO EM as used by Cheng and Agard is currently about 3 ångströms;
Cheng plans to use CRYO EM to examine the same molecule that Watson, Crick, and Franklin probed over 60 years ago DNA and, more specifically, chromatin, the term for DNA in complex with its associated proteins."
and I anticipate that CRYO EM will also play a significant role in this area.""Source: University of California San Francisc r
Discovered in the 1970s, SERS is a sensing technique prized for its ability to identify chemical and biological molecules in a wide range of fields.
and measure chemical and biological molecules using a broadband nanostructure that traps wide range of light,
When a powerful laser interacts chemical and biological molecules, the process can excite vibrational modes of these molecules and produce inelastic scattering, also called Raman scattering, of light.
Kai Liu. he ability to detect even smaller amounts of chemical and biological molecules could be helpful with biosensors that are used to detect cancer,
They also provided evidence that the same approach could be applied to the limbs of primates. he composite nature of our limbs makes building a functional biological replacement particularly challenging,
and Microbial Biology at UC Berkeley. o one had been able to put all the pieces together before.
There is a lot of biology that we haven been able to understand from our current methods, Brown said.
most after award-winning microbiologists but one Berkelbacteria after UC Berkeley. The work is supported by the Department of energy.
This discovery gives a new understanding to genetic diseases that are caused by mutations in these proteins.
a professor in Salk Molecular and Cell biology Laboratory and senior author of the new paper. hope people start to accept
Mutations in many nucleoporin genes has been linked to human diseases and developmental disorders, including some forms of leukemia and inherited heart problems.
researchers have assumed the mutations led to disease by altering the transport of proteins in and out of a cell nucleus. ow,
the implications for human biology are indirect at best. owever, mouse brains have long been accepted as excellent basic research models for the human brain,
and target research on"hotspots"most likely to be important for biological function. Known as SAPH-ire (Structural Analysis of PTM Hotspots), the tool could accelerate the search for potential new drug targets on protein structures,
"SAPH-ire predicts positions on proteins that are likely to be important for biological function based on how many times those parts of the proteins have been found in a chemically-modified state
"explained Matthew Torres, an assistant professor in the School of Biology at the Georgia Institute of technology.""SAPH-ire is a tool for discovery,
"Each PTM hotspot can then be ranked in order of highest to lowest potential for having significant biological function."
"Connecting SAPH-ire to other programs that convert mass spec data into actual PTM data could provide immediate biological relevance and prioritization for biochemists and others.
E. P. Taylor Professor of Pain Studies at Mcgill University and Director of the Alan Edwards Centre for Research on Pain. he realization that the biological basis for pain between men and women
#Microarray for Research into Haematological and Solid Cancers Oxford Gene Technology (OGT) released a new microarray designed to improve the accuracy and efficiency of cancer research.
because theye so hard to study, said Tony Hunter, American Cancer Society Professor, holder of the Dulbecco Chair in the Salk Molecular and Cell biology Laboratory and senior author of the new paper.
Nanotechnology, Biology and Medicine, was led by Jeffrey Zink and Fuyu Tamanoi, both members of the California Nanosystems Institute and Jonsson Comprehensive Cancer Center at UCLA,
who also is a professor of microbiology, immunology and molecular genetics and a director of the signal transduction and therapeutics program at the Jonsson Cancer Center. his demonstrates the effectiveness of our treatment
Tom Ellis, group leader of the Centre for Synthetic biology at Imperial College London, who was involved not in the research,
said the paper takes many of the best tools that have been developed for synthetic biology applications with E coli
was carried out in collaboration with the School of Biochemistry at the University of Bristol, the Wound Biology Group at the Cardiff Institute of Tissue Engineering and Repair,
which are critical to the development of heart tissue. his spatial differentiation happens in biology naturally,
said Warren Ruder, an assistant professor of biological systems engineering in both the College of Agriculture and Life sciences and the College of Engineering."
understanding the biochemical sensing between organisms could have far reaching implications in ecology, biology, and robotics.
who studies phyto-engineering for biofuel synthesis. e hope to help democratize the field of synthetic biology for students and researchers all over the world with this model,
. professor in Microbiology-Immunology and Medicine-Infectious disease. hese findings lay the foundation for future studies to further understand the mechanisms for how the escape to the bloodstream occurs.
professor of stem cell biology in the School of medicine led the research project, iscovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. he possibilities for regenerative medicine are still being reached in the form of clinical trials,
said Stephen Beverley, Ph d.,senior author of one of the studies and the Marvin A. Brennecke Professor and head of the Department of Molecular Microbiology at Washington University School of medicine in St louis. n the future,
said that the research is a significant step forward in bringing the power of CRISPR/Cas9 editing to human biology
(or nock in specific new sequences to correct mutations in T cells. As will be reported online in Proceedings of the National Academy of Sciences during the week of July 27
associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school.
s a cell biologist you dream of finding a new structure in cells but it so unlikely.
Warwick Medical school division of biomedical cell biology carries out fundamental molecular and cellular research into biomedical problems.
Without a molecular understanding of the underlying cell biology, intelligent directed therapeutic intervention is impossible. The division research focuses on fundamental cell biology processes such as cell division and intracellular communication.
Hey, check out all the research scientist jobs. Post your resume today s
#Could Dissolvable Microneedles Replace Injected Vaccines? Osaka University Study Eric is terrified. He stands outside the clinic and takes a few deep breaths before walking slowly through the automatic doors.
and the genetic mutations involved could help doctors catch the disease earlier, offering better treatment options for the patient.
However, researchers from the University of Cambridge have shown that variations in mutations across the oesophagus mean that standard biopsies may miss cells with important mutations.
A sample was more likely to pick up key mutations if taken using the Cytosponge, developed by Professor Rebecca Fitzgerald at the Medical Research Council Cancer Unit at the University of Cambridge. he trouble with Barrett oesophagus is that it looks bland
explains Professor Fitzgerald. e created a map of mutations in a patient with the condition
Some might carry an important mutation, but many will not. If youe taking a biopsy, this relies on your hitting the right spot.
The researchers found patterns of mutations in the genome where one etterof DNA might change to another,
Even in areas of Barrett oesophagus without cancer, the researchers found a large number of mutations in their tissue on average 12,000 per person (compared to an average of 18,000 mutations within the cancer.
Many of these are likely to have been ystanders genetic mutations that occurred along the way but that were implicated not actually in cancer.
where a patient would go from having lots of individual mutations, but no cancer, to a situation where large pieces of genetic information were being transferred not just between genes but between chromosomes.
Barrett oesophagus and the cancer share many mutations, but we are now a step closer to understanding
which are the important mutations that tip the condition over into a potentially deadly form of cancer.
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