and Omai Garner, associate director of clinical microbiology for the UCLA Health System. UCLA undergraduate Brandon Berg was the study first author,
This mobile platform was compared with the standard FDA-approved well-plate readers in a UCLA clinical microbiology laboratory.
the research team included Professor Vladimir Tsukruk from the Georgia Tech School of Materials science and engineering and Rajesh Naik, Biotechnology Lead and Tech Advisor of the Nanostructured and Biological Materials Branch
The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, director of the UIC College of Pharmacy's Center for Biomolecular Sciences
or producing designer therapeutics--and perhaps one day even non-biological polymers. No one has developed ever something of this nature."
"Our new protein-making factory holds promise to expand the genetic code in a unique and transformative way, providing exciting opportunities for synthetic biology and biomolecular engineering,
Professor Elizabeth Hartland, head of the department of Microbiology and Immunology at the University of Melbourne added that the international collaboration has brought together the immunological expertise in Melbourne
as a result of collaboration between Kobe-based medical device manufacturer My Tech researchers from Showa University uses a biochip,
a rare hereditary disease in which a mutation of the MEN1 gene on chromosome 11 makes patients susceptible to developing both benign
Animal studies previously linked this gene mutation with breast cancer; and the researchers further conducted an analysis of the utchmen1 Study Groupdatabase.
Right now there are 400 patients in The netherlands with this mutation. Breast cancer is a leading killer for women.
#Biodiesel production from Sugarcane A multi-institutional team led by plant biology professor Stephen P. Long from the University of Illinois reports that it can increase sugarcane's geographic range boost its photosynthetic rate by 30 percent
Long is an affiliate of the Institute for Genomic Biology at the University of Illinois s
#Uniting To Accelerate Pediatric Medicine Drug companies inherently absorb significant risk when developing compounds and biologics for clinical use.
whether the safety of concrete could be improved using a biological solution. This manufacturing query turned out to be the right question asked at the right time.
a microbiologist, the cracks that form in concrete are not just unpleasant to look at, they can eventually lead to structural failures. he problem with cracks in concrete is said leakage
Jonkers said he hopes his concrete could be the start of a new age of biological buildings.
Dr Ivan Poon, a molecular biologist at La Trobe University who led the work, said they may have uncovered a key part of the immune systems defence mechanism.
Christopher Brown, a microbiologist who was part of the team who took part in the study at the University of California Berkeley,
The team has named now 20 the new phyla they identified after award-winning microbiologists and one was called Berkelbacteria-after University of California Berkeley.
'There is a lot of biology that we haven't been able to understand from our current methods.'
Can we take some inspiration from biology and create a skin-like display?''The team is able to change the colour on an ultrathin nanostructured surface by applying voltage.
Alicia Jackson, the deputy director of Darpa Biological Technologies Office In virginia, made comments alluding to the technology at a biotech conference on Monday. or the first time
On earth, most synthetic biology projects use just two at the moment-e coli and yeast. want to use any organism that has properties
reported in the journal Science on Thursday, provides the missing piece in the biosynthesis puzzle.
Within a month, around half the mice with the mutation showed brainwave activity consistent with hearing
'This spatial differentiation happens in biology naturally, but we demonstrated this process in vitro, 'said study lead author Zhen Ma, a UC Berkeley postdoctoral researcher in bioengineering.'
#Pop-up silicon 3d structures mimic biological structures A way to make pop-up silicon structures which can mimic the shape of biological structures like the veins
and brain cells has been found by researchers at Northwestern University, Illinois and the University of Illinois at Urbana-Champaign.
Complex three-dimensional (3d) structures in biology (e g.,, cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life.
spent two years using a PCC store as a iving laboratory to understand how food waste is created in a retail grocery environment. n 2010 the WISERG teamith the help of biologists, computer programmers and engineerseveloped a solution:
despite a vast number of examples in the biological world. The potential of evaporation to power engineered systems is neglected largely.
as their beaks developed to better devour the food around them. his is an exciting case where mild mutations in a gene that is vital for typical development prompts phenotypic observable advancement,
and demonstrated an implantable, cellular-scale microfluidic and micro-optical interface to biology, with application opportunities not only in the brain but in other parts of the nervous system and other organs as well, says the study other co-principal investigator, John A. Rogers, professor of materials science and engineering at the University of Illinois. For now,
and observe and study the biological and medical significance of RNA misregulation. Previous technologies made it possible to attain static snapshots of RNA location
professor of stem cell biology. linical trials are still in the very early stages. However with this kind of product,
says lead author Satya Dandekar, who chairs the department of medical microbiology and immunology at University of California,
associate professor of cell biology and physiology at Washington University School of medicine in St louis. y finding the mutation,
They looked for mutations in the FMR1 gene that might impair the protein but not eliminate it entirely.
To see what effect this mutation might have, geneticist Stephen T. Warren and colleagues at Emory University replicated it in mouse brain cells
What does this mutation impair to cause only two symptoms of fragile X? To find out, Warren replicated the mutation in fruit flies.
Surprisingly, the fruit fly studies indicated that this single mutation increased the number of transmitters in brain cells, implicating a fundamental problem in
which the brain cells send out too many signals. To verify the mechanism in mammals, they turned to Klyachko lab,
researchers were able to verify the same effect from just the mutation and link it to human disease.
This single mutation in FMRP has the same overactivating effect on transmissions as the total loss of the protein.
The scientists say they can rule out the possibility that additional problems also are caused by this mutation
In many cases, genetic mutations that cause cancer involve chemical changes to individual building blocks of DNAREATING DNA ADDUCTS."
says medical entomologist Gregory Lanzaro, professor in the pathology, microbiology and immunology department at University of California,
biological agentsncluding mosquito-killing bacteria and fungind genetic manipulation of mosquitoes aimed at either killing them
The Shire-NPS deal comes less than two weeks before NPS faces a key decision from the FDAHETHER to approve its biologics license application (BLA) for Natpara
cellular, and developmental biology at CU-Boulder. Apoptosis is a natural process that kills billions of cells in a typical human body each day.
Jerry W. Shay, Ph d.,professor and vice chairman of cell biology at UT Southwestern, and colleague, Woodring E. Wright, M d.,Ph d.,professor of cell biology and internal medicine, found that 6-thio-2'-deoxyguanosine could stop the growth of cancer cells in culture and decrease the growth of tumors in mice.
Drs. Shay and Wright are co-senior authors of the study nduction of Telomere Dysfunction Mediated by the Telomerase Substrate Precursor 6-Thio-2deoxyguanosineappearing in Cancer Discovery. reatment with 6-thio
an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics appears in Genome Biology."
Marc Lecuit, M d.,Ph d.,Head of the Biology of Infections Unit at the Pasteur institute and senior author on the study,
has revealed several genetic mutations that may trigger the development of testicular cancer, in addition to uncovering a gene that may aid tumors in promoting resistance to existing drug therapies.
Their preliminary finding of a link between XRCC2 and platinum drug resistance was validated once they sequenced a sample from an additional platinum-resistant tumor. e have identified new potential driver mutations for this type of cancer
and provided new evidence of a link between mutations in the gene XRCC2 and platinum treatment-resistant tumours.
director of the center at Newcastle University. his novel approach would allow women who carry these mutations greater reproductive choice. e
"Dr. Toner and his colleagues anticipate that the Cluster-Chip will have an increasingly important role in stimulating new research on CTC cluster biology,
and to develop even better technologies to understand their biology in cancer metastasis. t
#Inexpensive Technique Developed to Manufacture Nanofibers Scientists at the University of Georgia say they have developed an inexpensive way to manufacture nanofibers,
"This discovery of a new prostate cancer-causing gene gives researchers a new avenue to explore the biology of the disease
"By showing that mutations in prostate cancer vary spatially in different regions of a tumor,
"Interestingly, the researchers determined that half of all prostate patients have either C-MYC or LMYC mutations,
If a mutation occurs in one of them, the person develops the disease. Scientists introduced a mutated human gene (TDP-43 or FUS) into C. elegans.
noted Veriepe. orms with an immune deficit resulting from the tir-1 gene's mutation were in better health
thus streamlining a challenging step in the biologics manufacturing process within a small operating footprint. The technology will complement Pall's STAXTM depth filtration products to enable continuous clarification of cell culture, enabling integration of the bioreactor with downstream processing
"15-PDGH is a key enzyme responsible for the biological inactivation of a group of signaling molecules, called eicosanoids,
and paint the cells without affecting their biological function, said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
but also for other tissue such as cardiac muscle or bone, according to the University of Liverpool Anthony Hollander, Ph d.,head of integrative biology."
and paint the cells without affecting their biological function, said Adam Perriman, Ph d.,from the University of Bristol school of cellular and molecular medicine."
but also for other tissue such as cardiac muscle or bone, according to the University of Liverpool Anthony Hollander, Ph d.,head of integrative biology."
. Purdue's Walther Professor of Cancer Structural biology and professor of biological sciences and chemistry who leads the research team."
Implications for nsp5 regulation and the development of antivirals, June 8 in the Journal of Biological Chemistry.
"said Reuben Shaw, a senior author of the paper, professor in the Molecular and Cell biology Laboratory at the Salk Institute and a Howard Hughes Medical Institute Early Career Scientist."
when we combined Reuben's deep understanding of the fundamental biology of autophagy with our chemical expertise,"says Cosford."
"Our study has great biological and medical significance, particularly in light of the huge disease burden of malaria,"explained senior author Manoj Duraisingh, Ph d.,professor of Immunology and Infectious diseases at the T. H. Chan School of Public health."
"In addition to a possible drug target, calcineurin underlies a very basic aspect of parasite biology. l
Unlike recent advances in personalized medicine that focus on specific genetic mutations associated with different types of cancer,
In a paper (ell-cell communication in yeast using auxin biosynthesis and auxin responsive CRISPR transcription factors published in the American Chemical Society's ACS Synthetic biology journal,
the researchers describe a novel cell-to-cell communication system that enables one yeast cell to regulate the expression of genes and influence the behavior of an entirely separate yeast cell.
'"Synthetic biologists, who assemble genetic parts in new ways with the goal of popping them into an organism to produce reliable behaviors,
With co-author and UW associate biology professor Jennifer Nemhauser, Ph d, . the UW team figured out how to make a sender yeast cell produce auxin,
such as those of the breast and bladder, according to Stephen Royle, Ph d.,team leader and associate professor and senior Cancer Research UK Fellow at the division of biomedical cell biology at Warwick Medical school."
"As a cell biologist you dream of finding a new structure in cells but it's so unlikely.
Additionally, 14-3-3s demonstrated a suppressive effect on cancer glycolysis, mitochondrial biogenesis, as well as a range of other major metabolic processes of tumors."
In plants as in animals and humans, intricate molecular networks regulate important biological functions, such as development and stress responses.
which is linked to several vital biological functions in humans. The team study (tructural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors appears in Science Advances."
#Biopharma Demand Is Driving the Cell Culture Market The production of biologic therapies such as vaccines, blood factors,
E coli has been studied in microbiology laboratories for many years and was the first organism to have its entire genome mapped.
The artificial ribosome, called Ribo-T, was created in the laboratories of Alexander Mankin, Ph d.,director of the UIC College of Pharmacy's Center for Biomolecular Sciences
and perhaps one day even non-biological polymers, point out Dr. Mankin.""We felt like there was a very small chance Ribo-T could work,
"Our new protein-making factory holds promise to expand the genetic code in a unique and transformative way, providing exciting opportunities for synthetic biology and biomolecular engineering."
when my biology classmate inhaled a little too much ether while mouth-pipetting. Using a beam of IR light invisible to the fly,
Associate professor of biology Mark Schnitzer and his team were even able to perform behavioral studies with the robot,
In this way, the fluidic computer may find applications in such areas as biology, chemistry, and other physical sciences and technology that use processes more akin to the properties of organization found in nature."
a tool that could be used for biomolecular tests such as pregnancy or diabetes monitoring. Surface plasmon resonance (SPR) is a process where a stream of light is directed onto a metallic film, with most,
along with the presence of certain trace gases and biomolecules. This has seen SPR commonly used in biosensing,
and demonstrated an implantable, cellular-scale microfluidic and micro-optical interface to biology, with application opportunities not only in the brain but in other parts of the nervous system and other organs as well,"says the study co-author John Rogers,
there is much variation in the cells with some presenting mutations and others appearing normal and healthy.
said study author Dr Xianbiao Wang. e hope our work provides inspiration for more research into the development of materials that mimic biological organisms. r
opening the door much wider for printing biomolecules. The breakthrough comes courtesy of a purified silk protein called fibroin
to test the ability of the ink to carry small functional biomolecules. In addition to bio-sensing gloves that could react selectively to different pathological agents,
and a Biotechnology and Biological sciences Research Council award, was published in the Science Translational Medicine journal in April.
This performance gap between software and wetware persists despite some correspondence between the architecture of the leading machine learning algorithms and their biological counterparts in the brain,
according to the request, such that dedicated exascale funding at the four DOE crosscuts Advanced Scientific Computing Research (ASCR), Basic energy Sciences (BES), Biological and Environmental Research (BER),
The scientists were trying to take the long-winding road from genetics to biology, which proved to be tedious and difficult.
Scientists can now directly study the biology of complex neurological disorders and from there nail down the responsible genes.
and this has got applications in chemistry, engineering, biology, medicine, so there's a lot of potential there and that's just for research purposes,
be loaded with biomolecules such as therapeutic drugs. They expect that this platform of 3d printed programmable release capsules will be useful in applications such as dynamic tissue engineering, 3d printed drug delivery systems, synthetic/artificial tissues, programmable matter,
Another important application area could be combinatorial screening of biomolecular gradients drugs, toxins, pollutants, etc. against cell types. ur method provides us with robust control over particle properties,
and triggered temporal release of the biomolecular payload. a
#Micron3dp Announces Breakthrough in 3d printing of Liquid, Hot Glass Israel Micron3dp has announced a breakthrough in glass 3d printing.
said Franco du Preez, a systems biologist and a founder of Lifeq. Over time, the system can identify qualitative trends such as the difference between someone having a jump in heart rate after a meal
Naturally curved, thin and flexible 3d structures are common in biology; examples include the circuits of brain cells and networks of veins.
and his colleagues want to create similarly complex devices that can wrap around these biological structures,
a co-author of the research and an assistant professor of microbiology at the institute. Not every kind of cell can contribute DNA to cholera,
John Mekalanos, a professor of microbiology at the Harvard Medical school who was involved not in the new research,
The device uses a droplet-based mass spectrometry technique that is able to spot even large biomolecules such as proteins
and the chipsclear polymer allows scientists to watch the small-scale biological processes in real time. he organs-on-chips allow us to see biological mechanisms
The device works by integrating biological spores which can expand or contract like muscles when exposed to different levels of moisture. ngineered systems rarely,
despite myriad examples of such adaptations in the biological world, wrote lead author Xi Chen
"said Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper's corresponding author."
"said Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper's corresponding author."
the ability to upconvert two low energy photons into one high energy photon has potential applications in biological imaging, data storage and organic light-emitting diodes.
the ability to upconvert two low energy photons into one high energy photon has potential applications in biological imaging, data storage and organic light-emitting diodes.
and reduce damage on biomolecules and two-dimensional nanomaterials, such as graphene March 18th, 2015graphene'gateway'discovery opens possibilities for improved energy technologies March 18th,
and reduce damage on biomolecules and two-dimensional nanomaterials, such as graphene March 18th, 2015news and information 30 years after C60:
Invista Professor of Chemical and Biomolecular engineering at NC State and the corresponding author of the paper describing the research,
and reduce damage on biomolecules and two-dimensional nanomaterials, such as graphene March 18th, 2015rice fine-tunes quantum dots from coal:
This study has brought together biologists and physicists from the Centre for Genomic Regulation (CRG) and the Institute of Photonic Sciences (ICFO
2015 Biologists and physicists have been working together to take a step forward in chromatin fibre observations and studies."
or precisely tailoring therapeutics to an individual's cancer cell biology. Toner and his collaborator Dr. Daniel Haber, M d.,Ph d.,also at MGH, recently used Cluster-Chip to capture
"Further analysis of the patients'CTC clusters yielded new insights into the biology of CTC clusters.
To characterize the biology of the clusters, the researchers measured a marker of tumor cell proliferation--an indicator of increased invasiveness and poor outcomes--in one breast cancer patient with high numbers of both single CTCS and clusters.
"Toner anticipates that the Cluster-Chip will play an important role in stimulating new research on CTC cluster biology:"
and to develop even better technologies to understand their biology in cancer metastasis
#Computing at the speed of light: Utah engineers take big step toward much faster computers The Utah engineers have developed an ultracompact beamsplitter--the smallest on record--for dividing light waves into two separate channels of information.
and biology,"says study co-senior author Euisik Yoon, Ph d.,professor of electrical engineering and computer science and of biomedical engineering and director of the Lurie Nanofabrication Facility at the U-M College of Engineering."
"In past decades, engineers have developed biological tools with better resolution, higher sensitivity, selectivity and higher throughput,
The goal of our lab is to develop tools that can be disseminated widely to the biology community to eventually impact clinical care for patients."
and graphene's electrical conductivity most likely contributed to the scaffold's biological success."Cells conduct electricity inherently--especially neurons,
which also included Martha Grover from Georgia Tech School of Chemical & Biomolecular engineering, has used so far the solvent to assemble three structures,
The nanodrug can have a variety of chemical and biological"modules"attached.""Each component serves a specialized function,
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015engineering Phase changes in Nanoparticle Arrays:
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015nanostructures Increase Corrosion resistance in Metallic Body Implants May 24th, 2015iranian
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015engineering Phase changes in Nanoparticle Arrays:
"finding a nanothermometer sensitive enough at this scale is a great step forward in the field of nanotechnology, with applications in biology, chemistry, physics and even in the diagnosis and treatment of diseases
In Kinsis, material scientists, chemists, physicists, biologists, electrical engineers, information scientists, food scientists and physicians work closely together.
Synthetic pieces of biological molecule form framework and glue for making nanoparticle clusters and arrays May 25th, 2015discoveries Tissue Engineering Scaffolds Produced from Natural Silk in Iran June 8th,
This substance has applications in the production of tissue engineering scaffolds as a biological material due to its appropriate mechanical properties and computability.
"##The research team included faculty members in bioengineering, chemical and biomolecular engineering, chemistry, electrical and computer engineering and mechanical science and engineering;
and that different physical mechanisms are used in different spectral bands to realize the same biological function of reducing body temperature.
Their discovery that there is a biological solution to a thermoregulatory problem could lead to the development of novel flat optical components that exhibit optimal cooling properties. uch biologically inspired cooling surfaces will have high reflectivity in the solar
if the ants were without the hair cover. he fact that these silver ants can manipulate electromagnetic waves over such a broad range of spectrum shows us just how complex the function of these seemingly simple biological organs of an insect can be,
Understanding and harnessing natural design concepts deepens our knowledge of complex biological systems and inspires ideas for creating novel technologies.
and material science students present this novel approach for the reproducible biosynthesis of extracellular, water-soluble QDS in the July 1 issue of the journal Green Chemistry.
"While biosynthesis of structural materials is established relatively well, harnessing nature to create functional inorganic materials will provide a pathway to a future environmentally friendly biomanufacturing based economy.
and Kiely along with Zhou Yang and Victoria F. Bernard of the Department of Chemical and Biomolecular engineering;
Can we take some inspiration from biology and create a skin-like display? As detailed in the cover article of the June issue of the journal Nature Communications,
and underwear incorporating sensing devices for measuring a range of biological indicators such as heart rate and muscle contraction.
This method is based on the standards of green chemistry due to the use of biological and green reactants instead of toxic chemicals and contaminants.
use of biological reactant and elimination of toxic and polluting materials and solvents are among the most important advantages of the proposed method.
in-vitro and in vivo biological testing), allowing researchers to fully comprehend the biodistribution, metabolism, pharmacokinetics, safety profiles and immunological effects of their medicinal nanoproducts.
*The technology was designed to track the machinery of biological cells, down to the tiniest bits of DNA, a single"base pair"of nucleotides among the 3 billion of these chemical units in human genes.
But the instrument could be useful well beyond biology, biochemistry and biophysics, perhaps in manufacturing.
The instrument must be stable to within about one-tenth of a nanometer (1 angstrom to biologists, equivalent to the diameter of a hydrogen atom.
and biological samples can be investigated today using X-ray tomography. This is done by recording images layer-by-layer
Researchers have developed a new approach for better integrating medical devices with biological systems. The researchers, led by Bozhi Tian,
The team achieved three advances in the development of semiconductor and biological materials. One advance was the demonstration, by strictly chemical means, of three-dimensional lithography.
The testing showed that the synthetic silicon spicules displayed stronger interactions with collagen fibers--a skin-like stand-in for biological tissue--than did currently available silicon structures.
or modifying the biological sample. Second, it stresses graphene's incredible potential in the area of sensing.##
"said Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the paper's corresponding author."
the processing of the woolen fabric samples by using optimum amount of honeycomb nanocomposite such as N-Ag/Zno improves the biological, mechanical and hydrophilicity of the fabrics.
"Besides solar energy, the ability to upconvert two low energy photons into one high energy photon has potential applications in biological imaging, data storage and organic light-emitting diodes.
and transport proteins are amazing machines present in biological membranes, "said Manish Kumar, assistant professor of chemical engineering, Penn State."
Thomas Walz, professor of cell biology and Rita de Zorzi, postdoctoral fellow, Harvard Medical school. The National Science Foundation, the U s army Corps of Engineers, an Extreme Science and Engineering Discovery Allocation and the Blue waters petascale supercomputer system at University of Illinois supported parts of this research h
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