would need to be addressed for engineered yeast to ever realize home-brew biosynthesis of medicinal opiates at meaningful yields."
In the lab of V. Reggie Edgerton, professor of integrative biology and physiology, neurobiology and neurosurgery, Pollock had attached electrical patches to the skin over his spinal cord.
and Biology Society, is UCLA research scientist Parag Gad. Lead coauthors were Yury Gerasimenko, director of the laboratory of movement physiology at Russia Pavlov Institute and a researcher in UCLA's department of integrative biology and physiology;
and Dr. Daniel Lu, associate professor of neurosurgery at UCLA David Geffen School of medicine. In a study published by the same team this summer in the Journal of Neurotrauma,
a postdoctoral fellow at Colorado who conducts research on nutrition and vascular biology. Dow underscored that engaging in regular physical activity appears to have broader effects lowering"bad"cholesterol,
by using a compound that biologists have used to track other molecules. Prions are a distinct type of protein they can self-replicate,
Peter Nilsson, a chemical biologist at Linköping University in Sweden, was experimenting with conductive plastics,
"said study researcher Bruce M. Spiegelman, a professor of cell biology and medicine at Harvard Medical school.
Alisa Blazek, a graduate student at The Ohio State university's Department of Molecular, Cellular and Developmental biology, agreed."
Epibone's work builds on the discovery from developmental biology that stem cells can transform into any part of the body.
and injected that material into mice that had been engineered genetically to have a mutation in the alpha-synuclein gene.
'Supercoiled'DNA Twists into Crazy Shapes DNA doesn't just coil in the iconic double helix immortalized in every high school biology textbook.
Building blocks of life After molecular biologists James Watson and Francis Crick first published a paper on the structure of DNA in 1953, the double helix became the iconic symbol of the code of life.
By measuring the level of genetic mutations in the ctdna, the test can predict the nature of metastatic disease
and can inform doctors about the potential treatments that could be targeted to address the genetic mutations.
an ARC Australian Laureate Fellow in the Department of Chemical and Biomolecular engineering at the University of Melbourne, was published today in the leading journal Advanced Materials.
an associate professor of chemical and biomolecular engineering at Nanyang Technological University in Singapore, who was involved not in this work. o me,
such as sensors that detect specific chemical and biological species and photonic devices that manipulate light.
#Major innovation in molecular imaging delivers spatial and spectral info simultaneously Using physical chemistry methods to look at biology at the nanoscale,
and each subcellular structure was a distinct color. o using this method we can look at interactions between four biological components inside a cell in three-dimension and at very high resolution of about 10 nanometers,
Xu said. he applications are mostly in fundamental research and cell biology at this point, but hopefully it will lead to medical applications.
ur research into these bio-inspired sensors demonstrates the huge value in applying the scientific learnings from the biological world to develop technologies for real world applications. d
that was wrapped around a three-dimensional object about the size of a few biological cells and arbitrarily shaped with multiple bumps and dents.
One of the most critical biological and medical tools available today, it lies at the core of genome analysis. Reading the exact make-up of genes,
scientists can detect mutations, or even identify different organisms. A powerful DNA sequencing method uses tiny
These sensors can detect biomolecule adsorption even at a few trillionth of a gram per millimeter square.
Higher binding capacity for biomolecules increases the signal levels and accuracy of analysis. The last several years
and interaction with a wide range of biomolecules. Stebunov and the team from the Laboratory of Nanooptics and Plasmonics at MIPT created
Thereafter a layer of streptavidin protein was developed on GO FOR selective immobilization of biomolecules. Scientists conducted a series of experiments with the GO chip
which is as close as biology has given us to a naturally magnetic protein nanoparticle, is really not that magnetic.
"This memristor-based technology relies on a completely different way inspired by biological brain to carry on computation."
Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th, 2015new Method to Produce Dual Zinc oxide Nanorings May 11th
Measurement of a single nuclear spin in biological samples May 11th, 2015graphene holds key to unlocking creation of wearable electronic devices May 11th,
Precise targeting biological molecules, such as cancer cells, for treatment is a challenge, due to their sheer size.
"said Orlin Velev, INVISTA Professor of Chemical and Biomolecular engineering at NC State and the corresponding author of the paper."
research assistant professor of chemical and biomolecular engineering at NC State and first author of the paper.
#New ORNL hybrid microscope offers unparalleled capabilities A microscope being developed at the Department of energy's Oak ridge National Laboratory will allow scientists studying biological and synthetic materials to simultaneously observe chemical and physical properties on and beneath the surface.
"It allows researchers to study the surface and subsurface of synthetic and biological samples, which is a capability that until now didn't exist."
and nanostructures to naturally occurring biological polymers, tissues and plant cells. The first application as part of DOE's Bioenergy Science Center was in the examination of plant cell walls under several treatments to provide submicron characterization.
The plant cell wall is layered a nanostructure of biopolymers such as cellulose. Scientists want to convert such biopolymers to free the useful sugars and release energy An earlier instrument,
also invented at ORNL, provided imaging of poplar cell wall structures that yielded unprecedented topological information, advancing fundamental research in sustainable biofuels.
It enables unaltered optical measurements of extremely small, dynamic changes in biological, chemical or physical processes.
such as sensors that detect specific chemical and biological species and photonic devices that manipulate light.
Nanotechnology, Biology and Medicine, and after further research may offer a novel mechanism to address this aggressive and often fatal cancer that kills 14,000 women in the United states each year.
Using physical chemistry methods to look at biology at the nanoscale, a Lawrence Berkeley National Laboratory (Berkeley Lab) researcher has invented a new technology to image single molecules with unprecedented spectral and spatial resolution,
"So using this method we can look at interactions between four biological components inside a cell in three-dimension and at very high resolution of about 10 nanometers,
"The applications are mostly in fundamental research and cell biology at this point, but hopefully it will lead to medical applications.
"This work is supported by the National institutes of health and partially by the Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense.
Biologists can zoom in on the organelles that make up a cell. Eventually he said, the researchers might be able to cut down on the exposure times even more
One of the most critical biological and medical tools available today, it lies at the core of genome analysis. Reading the exact make-up of genes,
scientists can detect mutations, or even identify different organisms. A powerful DNA sequencing method uses tiny
"In their approach, Gundlach and his team measure an electrical current through a biological pore called Mspa,
Biologists have recognized long that proteins have different structures to perform these roles, but the physical motion of proteins as they work on DNA has been difficult to detect directly."
These fine details may also help scientists understand how mutations in proteins can lead to disease
#Milestone single-biomolecule imaging technique may advance drug design Knowing the detailed shape of biomolecules such as proteins is essential for biological studies and drug discovery.
Modern structural biology relies on techniques such as nuclear magnetic resonance (NMR), X-ray crystallography and cryo-electron microscopy to discover the tiny structural details of biomolecules.
All these methods, however, require averaging over a large number of molecules and thus structural details of an individual biomolecule are lost often.
Now researchers from the University of Zurich, Switzerland have made a breakthrough by obtaining the first nanometer (one billionth of a meter) resolved image of individual tobacco mosaic virions
single-particle imaging technique for structural biology. The researchers describe their work in a paper published this week on the cover of the journal Applied Physics Letters, from AIP Publishing."
"The virions are imaged with one nanometer resolution exhibiting details of the helical structure of the virus. Our technique would be the first non-destructive imaging tool for structural biology at the truly single molecule level."
"Longchamp noted the technique would also open the door for"rational drug design,"an inventive process of finding new medications based on the knowledge of a biological target.
Second, low energy electrons are harmless to biomolecules, "Longchamp said. In many conventional techniques such as transmission electron microscopy, the possible resolution is limited by high-energy electrons'radiation damage to biological samples.
Individual biomolecules are destroyed long before an image of high enough quality can be acquired. In other words, the low permissible electron dose in conventional microscopies is not sufficient to obtain high-resolution images from a single biomolecule.
However in low energy electron holography, the employed electron doses can be much higher--even after exposing fragile molecules like DNA or proteins to a electron dose more than five orders of magnitude higher
than the critical dose in transmission electron microscopy, no radiation damage could be observed. Sufficient electron dose in low energy electron holography makes imaging individual biomolecules at a nanometer resolution possible.
In Longchamp's experiment, the tobacco mosaic virions were deposited on a freestanding, ultraclean graphene, an atomically thin layer of carbon atoms arranged in a honeycomb lattice.
#Brightness-equalized quantum dots improve biological imaging"In this work, we have made two major advances--the ability to precisely control the brightness of light-emitting particles called quantum dots,
and tunable number of photons per tagged biomolecule. They are expected also to be used for precise color matching in light-emitting devices and displays,
allow quantitative multicolor imaging in biological tissue, and improve color tuning in light-emitting devices.
The presence of some proteins in biological liquids of humans (blood saliva and urine) with determined concentration can be the sign of dangerous diseases.
Lysozyme protein has been selected as the target biomolecule in this research. The excess secretion of this protein can be a sign of malfunction in kidney performance
the physicists applied their ultrashort electron pulses to a biomolecule in a diffraction experiment. It is planned to use those electron beams for pump-probe experiments:
as are many important biological research tools. A wide-range of technologies, including LEDS, diagnostic tools,
and technological issues that needed to be addressed before fundamental questions in cell biology could be address in living cells.
#Cyborg beetle research allows free-flight study of insects (w/video) Hardwiring beetles for radio-controlled flight turns out to be a fitting way to learn more about their biology.
to be published Monday, March 16, in the journal Current Biology, showcases the potential of wireless sensors in biological research.
"Biologists trying to record and study flying insects typically had to do so with the subject tethered.
chemical and biological properties of the hydrogel are enhanced, Gaharwar explains. For example, the hydrogel can be designed to remain at the injury site for specific durations by controlling the interactions between the nanosilicates and gelatin,
Chemists, physicists, biologists, materials scientists and engineers team up to focus on these essential questions: Which material properties are new,
"Here we have a biological entity. We've made the sensor on the surface of these spores, with the spore a very active complement to this device.
The biological complement is actually working towards responding to stimuli and providing information
#Desalination with nanoporous graphene membrane Less than 1 percent of Earth's water is drinkable. Removing salt and other minerals from our biggest available source of water--seawater--may help satisfy a growing global population thirsty for fresh water for drinking, farming, transportation, heating, cooling and industry.
Given the importance of oxygen metabolism in basic biology and diseases such as diabetes and cancer,
"The material could help improve coatings used to protect surfaces from the build up of biological contaminants, particularly surfaces under the sea.
In nature, molecules called aquaporins, discovered in the 1990s, move water from one side of a biological membrane to another,
Their breakthrough, published today in the scientific journal PLOS Biology("Integration of Shallow Gradients of Shh
that is to say they can study the developing axons outside their biological context.""This new method provides us with several benefits
which uses fluids at a microscopic scale to miniaturize biological experiments, with the cellular, biological and molecular studies we conduct in laboratories.""
Recently, a team from the Department of Chemical and Biomolecular engineering in the School of engineering and Applied science has shown how to do just that.
"The technique could even be modified for imaging biological systems without the need for fluorescent labels.
and Biomolecular engineering at Korea Advanced Institute of Science and Technology (KAIST) have developed a novel photolithographic technology enabling control over the functional shapes of micropatterns using oxygen diffusion.
The research was dedicated also to the late Professor Seung-Man Yang of the Department of Chemical and Biomolecular engineering at KAIST.
#Scientists a step closer to developing renewable propane (Nanowerk News) Researchers at The University of Manchester have made a significant breakthrough in the development of synthetic pathways that will enable renewable biosynthesis of the gas propane.
working with colleagues at Imperial College and University of Turku, have created a synthetic pathway for biosynthesis of the gas propane.
Natural metabolic pathways for the renewable biosynthesis of propane do not exist but scientists at the University have developed an alternative microbial biosynthetic pathway to produce renewable propane.
The team was able to achieve propane biosynthesis creating a platform for next-generation microbial propane production.
a cancer biologist and an assistant professor of biomedical sciences and pathobiology at the Virginiaaryland College of Veterinary medicine. t was astounding.
She is also an assistant professor of biological sciences In virginia Tech College of Science. t exciting to see things no one else has seen before,
Nagoya, Japan-Yutaro Saito, Yasutomo Segawa and Professor Kenichiro Itami at the Institute of Transformative Biomolecules (ITBM
"As altering the para position has been a common approach in biology and materials science for creating benzene-containing functional molecules,
"says Kenichiro Itami, the Director of the Institute of Transformative Biomolecules.""Since starting this research in 2009,
biological fl uids, strong electromagnetic fields, and fast-moving objects. The strategy followed to design this kind of devices relies on the thermal dependence of the phosphor luminescence,
biological fluids, strong electromagnetic fields, and fast-moving objects. The temperature determination is usually based on the change of the luminescence intensity or decay times.
#Millions of liters of juice from 1 grapefruit (Nanowerk News) The Austrian Centre of Industrial biotechnology (acib) uses the positive aspects of synthetic biology for the ecofriendly production of a natural compound("Production of the sesquiterpenoid
"Synthetic biology could be of vital importance to humanity, as Artemisinin shows. Thanks to this substance malaria is curable.
which measures oxygen in cells and other biological material with high precision. The compound is based on rare earths emitting coloured light that vary in colour with the amount of oxygen present in the sample.
which are suited poorly for biological samples, useless in a microscope and quite incapable of showing where the oxygen is located in a cell.
which is highly compatible with biological studies, because it penetrates deeply into tissue, explains Sørensen."
a new Biopart Assembly Standard for Idempotent Cloning provides accurate, single-tier DNA assembly for synthetic biology".
"The new system called BASIC is a major advance for the field of synthetic biology, which designs and builds organisms able to make useful products such as medicines, energy, food, materials and chemicals.
BASIC, created by researchers from Imperials Centre for Synthetic biology & Innovation combines the best features of the most popular methods while overcoming their limitations,
which is promoting the adoption of synthetic biology by industry. Two industrial partners Dr Reddys and Isogenica are also already making use of BASIC in their research laboratories.
Professor Paul Freemont, co-Director of the Centre for Synthetic biology & Innovation, says: This system is an exciting development for the field of synthetic biology.
If we are to make significant advances in this area of research, it is vital to be able to assemble DNA rapidly in multiple variations,
which is the future of synthetic biology. If innovations in the field are to be translated into the marketplace,
and will be one of the first protocols to be used in our new, fully automated platform for synthetic biology,
developed by researchers at University college London with funding from the Biotechnology & Biological sciences Research Council (BBSRC),
"Fundamental bioscience research is vital to reveal the biological mechanisms underlying normal physiology across the lifespan.
said lead researcher Prezioso. his memristor-based technology relies on a completely different way inspired by biological brain to carry on computation.
and may even have implications for understanding biological systems. Working at the Center for Nanoscale Materials (CNM) and the Advanced Photon Source (APS), two DOE Office of Science User Facilities located at Argonne,
and can be engineered for physical and biological applications. However, on their own, these materials are terrible for use in the electronics world.
an ARC Australian Laureate Fellow in the Department of Chemical and Biomolecular engineering at the University of Melbourne, was published today in Advanced Materials("Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets").
"Through a combination of high-resolution cryo-electron microscopy (CRYO EM) and a unique methodology for image analysis, a team of researchers with Berkeley Lab and the University of California (UC) Berkeley has produced an atomic view of microtubules
and structural biology at UC Berkeley and investigator with the Howard Hughes Medical Institute, is a leading authority on the structure and dynamics of microtubules.
In this latest study, she and her group used CRYO EM in which protein samples are flash-frozen at liquid nitrogen temperatures to preserve their natural structure,
With CRYO EM and their image analysis methodology, they achieved a resolution of 3. 5 Angstroms, a record for microtubules.
Beyond their importance to our understanding of basic cell biology, microtubules are a major target for anticancer drugs, such as Taxol,
and other biological tissues because of needle buckling or fracturing on penetration. high-aspect-ratio microneedles penetrating brain tissue A research team in the Department of Electrical and Electronic Information Engineering
which dissolves upon contact with biological tissue. Silk fibroin is used as the dissolvable film because it has high biocompatibility,
and probe biological molecules to explore their potential use as new drugs. The device has the potential to replace gold nanodevices used in current analytical techniques,
This quickly damages delicate biological samples and potentially melts the equipment. The innovation is expected to expand the ability of researchers to investigate potential new drugs more rapidly and accurately,
Common laboratory analytical techniques such as Raman and fluorescence spectroscopy determine the properties of biological molecules,
2015("Systems biology definition of the core proteome of metabolism and expression is consistent with high-throughput data".
"said Laurence Yang, a postdoctoral researcher in Palsson's Systems Biology Research Group at UC San diego and a co-first author of the paper.
It is a systems-biology-based definition that takes into account not just the minimum set of genes,
and integrated them in the form of a computational model to arrive at our systems biology definition of the paleome
Your disease is caused by a mutation in gene X, and were going to correct this mutation to treat it.
In theory, genome engineering will eventually allow us to permanently cure genetic diseases by editing the specific faulty gene (s). Revolutionizing health care Genome engineering involves the targeted
at least with respect to a chosen trait, could significantly aid basic biological research and development of high-throughput assays, says John Slater, assistant professor of biomedical engineering at the University of Delaware.
that was wrapped around a three-dimensional object about the size of a few biological cells and arbitrarily shaped with multiple bumps and dents.
and is the first time that scientists have reported the ability to create biological structures that are programmed readily to assemble
with a flick of a switch and a temperature jump, make a huge range of biological molecules that either assemble or disassemble."
and then go back to explore how biology is already making use of them
#A thermal invisibility cloak actively redirects heat Light, sound, and now, heat--just as optical invisibility cloaks can bend
. who is the Judah Folkman Professor of Vascular Biology at Harvard Medical school and Boston Children's Hospital as well as Professor of Bioengineering AT SEAS."
Biologists can zoom in on the organelles that make up a cell. Eventually he said, the researchers might be able to cut down on the exposure times even more
These sensors can detect biomolecule adsorption even at a few trillionth of a gram per millimeter square.
Higher binding capacity for biomolecules increases the signal levels and accuracy of analysis. The last several years
and interaction with a wide range of biomolecules. Stebunov and the team from the Laboratory of Nanooptics and Plasmonics at MIPT created
Thereafter a layer of streptavidin protein was developed on GO FOR selective immobilization of biomolecules. Scientists conducted a series of experiments with the GO chip
#3d printed scaffolds could enable the release biomolecules into the body with exceptional control (w/video) Tissue development is guided by gradients of biomolecules that direct the growth, migration,
Now, researchers are one step closer to this goal thanks to the creation of new 3d printed scaffolds that enable researchers to release biomolecules into the body with exceptional control.
this time filled with blue food dye to represent a different type of biomolecule. The layering pattern continues until the gel achieves a predetermined height.
when different types of biomolecules are released from the gel by varying the shell coatings of the capsules
They can also be filled with a wide variety of biomolecules. ne can imagine filling the capsules with molecules such as medications
Now, researchers report in Biomacromolecules("Biodegradable ph-Sensitive Poly (ethylene glycol) Nanocarriers for Allergen Encapsulation and Controlled Release")the development of a potentially better allergy shot that uses nanocarriers to address these unwanted issues.
The current gold standard for Ebola virus detection relies on a method called polymerase chain reaction (PCR) to amplify the virus's genetic material for detection.
nontarget biomolecules are washed off, and the bound targets are released then by heating, labeled with fluorescent markers,
"In their approach, Gundlach and his team measure an electrical current through a biological pore called Mspa,
Biologists have recognized long that proteins have different structures to perform these roles, but the physical motion of proteins as they work on DNA has been difficult to detect directly."
These fine details may also help scientists understand how mutations in proteins can lead to disease
#Brightness-equalized quantum dots improve biological imaging Researchers at the University of Illinois at Urbana-Champaign have introduced a new class of light-emitting quantum dots (QDS) with tunable and equalized fluorescence brightness
and tunable number of photons per tagged biomolecule. They are expected also to be used for precise color matching in light-emitting devices and displays,
allow quantitative multicolor imaging in biological tissue, and improve color tuning in light-emitting devices.
nuclear magnetic resonance (NMR) and simulation and is the result of an international cooperation involving researchers from the Institute of Structural biology (ISB, CEA/CNRS/Joseph Fourier University) in Grenoble, France, Purdue University, USA,
and flatter than any biological structure. The Berkeley Lab scientists say this never-before-seen design rule could be used to piece together complex nanosheet structures and other peptoid assemblies such as nanotubes and crystalline solids.
and Ron Zuckermann, who directs the Molecular Foundry Biological Nanostructures Facility. They used the high-performance computing resources of the National Energy Research Scientific Computing Center (NERSC),
they were surprised to see a design rule not found in the field of protein structural biology.
and extended into large sheets that are flatter than anything nature can produce. t was a big surprise to find the design rule that makes peptoid nanosheets possible has eluded the field of biology until now,
isolated from their usual environment. ynamic nuclear polarization has a capacity to transform our understanding of biological structures in their native contexts,
says Susan Lindquist, a professor of biology at MIT, member of the Whitehead Institute, and one of the senior authors of the paper, which appears in the Oct 8 issue of Cell("Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus").
when youe thinking about its biology. To make sure they are getting data only on the protein of interest,
Alexander Rohrbach conducts research at the Department of Microsystems Engineering (IMTEK) and is an associate member of the Cluster of Excellence BIOSS Centre for Biological Signalling Studies of the University of Freiburg g
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