Tropes

ScienceDaily_2014 04502.txt

#New methods to identify MRSA in pigsit is important to keep the number of MRSA infections at a low level. In a Phd project at the National Food Institute Technical University of Denmark the latest technologies within whole genome sequencing were exploited to develop new methods to identify genes which are important for the survival of MRSA in pigs. Traditionally MRSA has been associated with severe infections which occur in hospitals and result in prolonged diseases and increased mortality. However in recent years MRSA has spread to the rest of the community e g. MRSA CC398 is found in pig production. MRSA is resistant to the antibiotics with which we normally use for treatment of Staphylococcus infections. In her Phd project at the National Food Institute Phd student Mette Theilgaard exploited the latest technologies within whole genome sequencing and studied the entire DNA of MRSA CC398. These studies have resulted in new methods high-throughput approaches which can identify genes important for the survival of MRSA in pigs. High-throughput approaches can identify those genes in the total gene pool of the bacteria which are essential or the presence of which is advantageous for the bacteria under some given circumstances. Transfer of disease from animals to humansthe fact that MRSA can spread from animals to humans where they may result in infections has caused great concern in recent years. LA-MRSA ST398 is a new type and has turned out to be particularly successful in colonisation of pigs from where it may transmit to humans. Therefore several monitoring studies focus on locating the origin of this MRSA type and its potential. Several central questions still remain unanswered which makes it difficult to control the spread of this MRSA type. LA-MRSA ST398 is zoonotic i e. it can be transferred directly from animals to humans and cause disease. Thus it is not sufficient to eradicate the bacteria from humans. LA-MRSA ST398 has proven to be particularly successful in colonisation of pigs. By studying which genes are essential for the bacteria in pigs it may be possible for researchers to identify the factors important for the bacterium to colonise on pigs. We still don't know which specific genetic factors in this MRSA type facilitate the spread from animals to humans. MRSA backgroundmrsa stands for methichillin-resistant Staphylococcus aureus. When bacteria are exposed to antibiotics they protect themselves by developing resistance. They do this by changing their genes either by mutating or by transferring resistance genes among themselves. It is therefore important not to overconsume antibiotics but only to use the necessary amount. Staphylococci are bacteria which can be found in humans animals and our surroundings. Staphylococcus aureus is part of the normal nasal and skin flora of approximately 50%of the population. Staphylococcus aureus may cause various infections ranging from superficial wounds and abscesses to severe infections such as bone inflammation and infection of the heart valve. In hospitals Staphylococcus aureus is the most frequent cause of infections following surgery. Story Source: The above story is provided based on materials by Technical University of Denmark (DTU. Note: Materials may be edited for content and length h

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