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ScienceDaily_2014 05835.txt

#Progress in allergic asthma research after ingestion of fruitsresearchers at the UPM suggest that the interaction between two proteins can be the responsible for the allergic asthma episodes after eating an infected fruit. A research group of the Centre for Plant Biotechnology and Genomics (CBGP) of Universidad Politã cnica de Madrid (UPM) conducted infection assays of commercial kiwis with Alternaria alternata spores which is a pathogenic fungus involved in chronic asthma in children. Researchers studied the behavior of this fruit and they found that the infected kiwis had the major allergen of the fungus although symptoms of rot were seen not. This could trigger the involuntary ingestion of the fungus found in this fruit causing an asthmatic crisis in people allergic to Alternaria. Alternaria alternata is a fungus that proliferates in fruit and vegetables crops and also when are collected and are on sale for the final consumer. A protein known as Alt a 1 and related to the virulence is found in the spores this protein is described as the major allergen of this fungus. According to this research this protein can be a major cause of childhood asthma in US. When a pathogen infects a plant the defense response is activated producing an increase of certain proteins related to the defense (known as protein 5). Likewise the fungus increases the production of the proteins involved in attacks or virulence. However the symptoms of rot by Alternaria alternata are seen not in some fruits for example in kiwifruit. All this can cause the involuntary ingestion of the fungus when eating the fruit. Researchers conducted tests by infecting commercial kiwifruit with spores of Alternaria alternata and they detected the presence of Alt a 1 a protein of fungal virulence. Also researchers studied how this protein is involved in the activation of defense protein 5 in kiwifruit. Fourteen days after the infection the kiwifruits showed a regular aspect without apparent development of the fungus but through tests conducted in lab (microscopy of specific staining fungus and Kiwi proteins) they detected the presence of Alt a 1 in the pulp. What is more they observed that this fungal protein is found in the same areas that the defense protein of the kiwifruit. Using computer modeling techniques they identified a surface area in Alt a 1 susceptible to interact with the defense protein. In that interaction Alt a 1 is joined to a region of the protein 5 of the kiwifruit causing a remarkable decrease of its defense activity. These results reveal that Alt a 1 is an inhibitor of the defense proteins of family 5 which is particularly important in processes of fungal infection. Researchers did observed not development of the fungus in kiwifruit but they indeed detected the presence of its major allergen through specific staining. From health point of view the presence of Alt a 1 in apparently healthy kiwis is important since Alternaria is described as a major cause of chronic asthma in children. These results suggest that patients allergic to Alternaria can suffer an allergy attack after eating infected kiwifruit. Story Source: The above story is provided based on materials by Universidad Politã cnica de Madrid. Note: Materials may be edited for content and length. Journal Reference r

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