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ScienceDaily_2013 04417.txt

#The pig, the fish and the jellyfish: Tracing nervous disorders in humanswhat do pigs jellyfish and zebrafish have in common? It might be hard to discern the connection but the different species are all pieces in a puzzle. A puzzle which is itself part of a larger picture of solving the riddles of diseases in humans. The pig the jellyfish and the zebrafish are being used by scientists at Aarhus University to among other things gain a greater understanding of hereditary forms of diseases affecting the nervous system. This can be disorders like Parkinson's disease Alzheimer's disease autism epilepsy and the motor neurone disease ALS. In a project which has just finished the scientists have focussed on a specific gene in pigs. The gene SYN1 encodes the protein synapsin which is involved in communication between nerve cells. Synapsin almost exclusively occurs in nerve cells in the brain. Parts of the gene can thus be used to control an expression of genes connected to hereditary versions of the aforementioned disorders. The pig The SYN1 gene can with its specific expression in nerve cells be used for generation of pig models of neurodegenerative diseases like Parkinson's. The reason scientists bring a pig into the equation is that the pig is suited well as a model for investigating human diseases. Pigs are very like humans in their size genetics anatomy and physiology. There are plenty of them so they are easily obtainable for research purposes and it is ethically easier to use them than for example apes says senior scientist Knud Larsen from Aarhus University. Before the gene was transferred from humans to pigs the scientists had to ensure that the SYN1 gene was expressed only in nerve cells. This was where the zebra fish entered the equation. The zebrafish and the jellyfish The zebrafish is as a model organism the darling of researchers because it is transparent and easy to genetically modify. We thus attached the relevant gene SYN1 to a gene from a jellyfish (GFP) and put it into a zebrafish in order to test the specificity of the gene explains Knud Larsen. This is because jellyfish contain a gene that enables them to light up. This gene was transferred to the zebrafish alongside SYN1 so that the scientists could follow where in the fish activity occurred as a result of the SYN1 gene. We could clearly see that the transparent zebrafish shone green in its nervous system as a result of the SYN1 gene from humans initiating processes in the nervous system. We could thus conclude that SYN1 works specifically in nerve cells says Knud Larsen. The results of this investigation pave the way for the SYN1 gene being used in pig models for research into human diseases. The pig with the human gene SYN1 can presumably also be used for research into the development of the brain and nervous system in the fetus. I think it is interesting that the nervous system is preserved so well from an evolutionary point of view that you can observe a nerve-cell-specific expression of a pig gene in a zebrafish. It is impressive that something that works in a pig also works in a fish says Knud Larsen. Story Source: The above story is provided based on materials by Aarhus University. Note: Materials may be edited for content and length. Journal Reference e

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